Basic Information

Gene Symbol
-
Assembly
GCA_947359385.1
Location
OX375766.1:5793674-5802992[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.33 19 6.0 0.2 2 21 1719 1738 1718 1739 0.87
2 7 8.1e-05 0.0046 17.4 0.7 2 23 1875 1896 1874 1896 0.95
3 7 0.002 0.11 13.0 4.1 1 23 1916 1938 1916 1938 0.97
4 7 0.0055 0.31 11.6 4.2 1 23 1976 1998 1976 1998 0.98
5 7 0.0014 0.081 13.5 3.0 2 23 2021 2042 2021 2042 0.95
6 7 0.057 3.2 8.4 1.1 1 19 2069 2087 2069 2089 0.96
7 7 0.4 22 5.8 0.8 5 23 2454 2473 2451 2473 0.91

Sequence Information

Coding Sequence
ATGGATAGACTGAACCAGTTGAGCGCGGGAGGCGAGGCGGGCTGCGGCGACTCCACTCTCGATACGTCATCCTCGCCGAGCGAGGGCTTCGTGTCGGCCAACGAGAGCTCTTCTAAATATTTCTCCCTATCAGACTCCACATTTGACATCGACCCCATCAAAGATGTCTCGTTGGCGTCGGTGGCCTCCACCGCCTCTGAAGCCGATCGTACCATGACCAGTGAGGATGAGCTTATTTCAAATCTCTCACCAATCACAAAGAAGGATGTCATGCTGGAAAGCTACAAGATGGGCAAACAGATTGAGGCGGCCAATATTCTCTCTGGTGGTGTTGATATTTTTGATGACAATGACAATTCATATGATGGTGATGAGCTTGTCATTGATGATAATGTGGAACTGGATGAAAAGTCAAATCTGGATAAGTCAGATTCGCAATTCAAAGGTGATGAGACTGCAGTAGAAGCTACTTTAGTGGACTCTCCGTTGGATGTGGCTAGTAGAGATACCGAGGTGGTGCTTCAGATTGATGGTAACAATGTTGATGCCATAGATATTGGGAATGGCCTATACTTGTATCGTAAGGACGGACAAGAAGAATTGGCAGCGGTGCAGATAATTACAGAGGATGATCAGCAACAACCAAGTTTCAAGTTCCTGAAAGTGCGTGAGAATGCAGAAGGAAACTTAGAAGTCTATGAAGAATTTGAAATTGAAGTTACGAAAGAAGTGTCTGCAAAAGATTCAAAACAGTCAGTTAAGAAAACGTCACATACACCTATCAAGGAAATCAACAGAGTTATAAGTGATGCATCAAGCAACAAAGTTACTGAAAACATAGAGAAAACATCTCCAAAAGAAGAAGTTTCTACATCTGCAAAGGAAGTAGACACTGATGTGAAAGAAATTACGGTGGAATCCAAAACCGAAATAAATTTCAACGGGAAGATGAAGTTTAGTGAGTCGCGGAAATCGCCAGTTGTAGGCAGCTTCACGCCGATGACATACCATTCTACTCCTAACAAGGAAGGAAAACCTCTCACTAAAACTATGGTGGATCTTCAATTGCACCCAAATCGGCATTCTGATAATGTGAAGAAAACCATTGAAGTGCATACAGATAGTCAAAACAAGAAAATAGTGACAGATGAGTTCCATAAACCAAAACTAGAAACCCAAGCAATGAAAAGTTCCACTGATAACACCATCACAAAAGAAAAAATATCAACAGAATCACTAGAAGAATCTTCTGATGTCACTGAAAAATCTGGAAAAGATCCGCAAGTTACTGATAACATTTCCAGTTGTTCTGCAAATATTAAACCAGGTACGGATAAACTGAGTCACTTAATTGGTGATGTGAGTAAGAAATTGCTGAGTCCCACTTTAATTAATGTTGACAGTATAACCAAAGTTGAGGATATTGTCACAATAGATATTGAAAATAAACAGATAGAAGCAGAAACAAGTCTTCCAAAAAATGAAGAAAGGCATATCCAAGATACTGACAATAAAGACATAGATGACCCTAAGCCGATGAGTACAACTGTTGATGCATTAAGCACAACAAATTCTACTCATAATCCAGTTCTAGAAATTGGAAGTTCTGAAAAAATTCCTAGTGCTTCAAAAGAAGTAAATACAGAAAGTCTTTTAACAAAAGATTTATTTAAAAGTGGTTCCGTCAAAGAAGTAAATAAAGATGCAACAACTATGCTGGAATCTAAAACAGTTGATAATCTAATTGTGAAATCTCAAGCTGTAAAAACGAATGAACAGAAAGAAGACAATACGATATGTGAAATGTGTCCAGAGATTGCAACAAGTAATGTCATAGATTCACAGTCGCCTCACCAGGATTCAAATGTTTTTCATCCAAAAACACATATAGATGTCATTTTGCAAAAGGGTTCTCATGAAAGACCCGATGAAGTTGGAGTAAAGCACCTCCAACTTCATCAGACATTGAAGCCTTTACCAGAATTTTCCTCGAAAGATTCTAAAGCTAGTGATAAGATTATTGAAGAAAATAAGATCCCAATTATACCAAGTGTTCCAACAATGGAAATGACCACCTCGAAACATGAATTTCATGATGATAATTTTGCCATTGTTGCAAAAACAGTGCCTACCATAAGTCCAAATGAAGGAGAATCAGATCAAAAGAGCAAGAACAACACTGCAAAAAAGGATGTACAATTAAATGAAGGAAACAAAAGTACAGGAAGCACGGAAAACAAATCAGATGCGAATACTGATAAATATAAACAATTACCAAAGGCTGAGCTTCACACAGTTGCTGCAGAGAGTGCTTGTAATACATCGCTAGAAACTAAATCATCAATTTCACCCTCAAATGTTGAAATTACGACAGTATCAGAAATTGATAAAATGATCGGTGTTCCAAAAGAAATCACTTGCAAGCCACATTCAGTACAGTCGAAAACAGAAATAATATCTTCATCAGCGAGTGGTCCCAAGAAAGTGTTAACTATGGAAAAATATGATCCAGTTTCTAAAGCACCTGAGCAAAAGGCTGTTACAAAAACTGAAAAATTGATAGTCTCTAAAGATATTGCGTCCAACTTAATTTCGACGCCCGAAAGTTTGAATACAGTTCCTAAAACTGAACCCATAACTGTTGGAACATGTACTACGTTCAAGCCAGTTTCAAAAACTGAAAGTACATCTCTAGTTGAAAAAGAAATTGTAACAAAGGCAGCATCTAAAACTGAGATGTTCAATCCCGTAGGAATTAAAATTGACACTAAATGTGAGACAAATGTTGAAAAAGAAATTGTAACCAAGGCAGCATCTAAAACTAAGATGTTCAATCCAGTTGGAATTAAAATTGACCCTAAATCTGAGTTAAATGTTGAGAAGTTTAATGCAGTCGCAACAGATATTTTAAATACAAAAACTACAATGGATTCTGTAAAGTCTAATAAGAATTATTCTCATAATAAAGAACAATGTACAGATAAGAATGAAACAAGAGTTCCAGAAGTGTCTATTTCTGGAGCAAAACCCATGAATAACAATCATGCTGCAGTCCCGTTTGGCAAATGGACTGATGCGAACAGGCAAGAATTCTTGAGTAAGTTTAAAGATATTAAAATTCCTGCACCAAGCAACACAAAACAGATAAAAAACTCCAATGATTTAAATAGAATAGATGTTTTGAAAAAGATCGACAGTCAAAGATCTAACAATGCTTCTTCTAAACCTCAAGATAAATCTACTGTAAAAGATACTGTTTTTTCGAATAAAATAGCTCCGCCGAAGGTAACAAAAATACCAGTCAAAACTGAAGGGCCTAAAATAAAGCCTAAACCCGAAACTGTAGTTGAAAACAACACATTGAAACAGGATAGCAAGATAAAAGAAAAAAGTACATCTTTGGTCGTTGCTAATGTCGGAACTTCTGCCGAAATTAAGCCAGGCACTGAGGAAAGAAGAAATGTTAATGTTAATATGACTAATTTAATTACCAGAACTATTGTAGACATGCTGAATCGACCTGTTCCGATGACTATGTGTAAAAGTTCTCTTAGCGAGCCAAAACCAAGGCCGATAGAGAACACTGATGTGAAAGTTACTTCGGAAGAATCTTACAAAAACTCCAATTCTGATGTAAAAAAGCTGGATGATGACAGTAGTGGTTCTTTAGATGACATTGAAATGAAAATGAACGAGCTACACGGAATTCCATTCGTTGAAAGACCTCCACACGAATTGCCTAGATTGCATAAAACTTATAGTAAAACTAGTAAGGATTCAAATCTGGCAAAAAAAGTTCAGAAAAAACCTATTTTTGCTGCCCCTACTACAAGCATACAAAGTTTGACTCAGACTATAATAGATGTTGATTCAGACGACGAACTCATTGAGCATGAGCCTGTTACTGGCGATACAGATTTAAATAAGAAAAAACTAGTACCAGTTATACCGGCATCTGTCAAAACCCAGTTTACTGATAATAAAACAGTTCCAACAAGTCAGGACCCACAAAAGAAAAACCCAGTCATAACTGAGAATGACTTCGATAAATTTGCTAGAAGGAATTCAATCACTTACGAAAATTGTTTGACTGTTAAGTTTGACGGAAAAGAACCAGCTAACGTGGTCCAGACTGTAAAAGAGAAAGACGCCAAGCCATGCCCAAGAAATGAAAAGATCCGCGTGGATCCTAACACAAAATTGCCTTGCAAACAATATACATGTCAAAATGTCTATGTTGGAAATGTTTCACATATTGGTAAATTCGGTTCGATGACTGAAGATCCCAACAGTAAAAACTATCAGTCTAAGATAGCTACAGCGTACCAGTCAGCTTTGAGCTCGAAACGCCAGATAGATCGACCTATTACAATCATCGAGGACAAACCGGTTAAAGTGGTATTCATGGATGCTAATGCTGAATTTGTCCCAAACCAGTTAAATGTGCAAGGAAAAGAACTGTCACCTGCTAAAAAGCCAGCTTCAGACGTGGATGCTGCAGTGAATAACGCCCAATCTATTAACATTGATGTAATGGACGCTGTTGATGATAGTAAACAGCTTGATGATATGAAGACTAAGACTAAACATCAAAGAAAACAAGTTTTGACACCTGTTGAGGCTCCGGACTTAGAACTTATTCAACCAGGTGAAATCGGTATTGACGCTACACCAAAAAAGAAAAGAAAAACCGATGACAATAAAACAGAAAAGAACCTCAAAAGTCCAGTACATAAGAAACAATATTTGTTAGGACGTAGTAATGTGACTGGTGAAAAAACTTCTGACATTAATAATCCTGAGAAAGAAACAAGTCGTTCTGAGATCGTGCCGGAGAGGAGCGCTGTCTCGGCTATCGATAGTTTAGTCAAAGCAGCTGAGTTATTAGAAAACCAGTCTGTTGAGAGTAGCTCTCCAAACCCTGATTCTCAACAAAGTACACCTGTTAAAAGGGGAAGAGGCAGACCTAGAAAGTATCCTCTACCTGAAGGAGCCACTGATAGCAAAGTAGCTAGCCCTAGTCCTCAGAAGAAGCCTAGGCTGATAGACGCTAAACCTGTCAAAGATGATTCGGTCACAGACGACAATGAAAGCACTGATGAAGAAGAAATCACCAGAGAAAATTGGACGATGGGCAAAATTAATGAAAACATAGTTTGCCCCATTTGCAACAAACTATTTAGATCCGAAAACGTAGTTTTCAAACACGTAAAACACTGCACAGGAGTTTCGCCCAGCAGATCCGAGTCGGAGAAAATGAGTCCGCGTAGAAGAAGACACTCACGAGAATCCGACAACAAATCATTCGAGAGTAAATCCGATCATACGGATGTTGATGAAAAACTGAGCGAAACTGTGATAAAGACACCTACAAAACGCAAATCTCACGAGTCTGTCACAAAACATGAAGGAAAAACTGGGCACAAAGACAATGAAATAATTGTCAGTAACGATACACCCGTTAAGGATCAAGTAAACAAGATATTAAAAGAAAATCCCGAAAATGAGATTGTAGTAAGAAGTAACAAAGAACCAACTAACAAAAAAGAAATTTCTGTGAATAAATTAGGGAAGGTGAAGAAATTGACAAAAACTAATTTCAGAGAGCGCTCTAGTGATCTTGTCTGTGAATTCTGCGGCAAAACATTCAGGCAACTATCTTACCTAGTGAACCATAAGTTACAGCACAGAAAAGAACAAAAAAATAAACTTGAAACGAATATACCTGCAAATAAAATACAGGTGTTTAGCTGTGAAGTTTGTAAGAAAGAATTCAGGAAATTGCATCATTTAGTGCAACATAGAATTATTCACAACTTAGAAGTGCCTACGCGCACTCTACGAAAGAGTTCTTCAGAGCAGACCGAAAATAAAAATGGTAAAGAACAGGCCACACCTAAACAGAACGACGATACTAGCGCAGGTTTTCGATGCGAACCTTGCGATAAATCATTTAGAAAACTACATCATTTAGTTGAACATAGGGAAACTCACGACGGTATAAACAGACAGAAAAATACAAGTGCTCAAGCAATCATTGAGAAGCTTCCCCCACCTCCCACCTGTGAGGTTTGCAAAAAAACATTCAGGAAGCTGAGTCATCTGATTGAGCACAAAGAACAACACGTCGAACAAGTGGAAACTAGTTCAGAAAAATCAGACGATAAGAGTGTGAAAAGTTCATTATCAACCAAAGATATCATCCATGAATGTTCTCTTTGTTACATGGTGTTTCCTAATGAGCATTCGCTAAATAAACACTTCGTGATTTGTCAACAAAAGAAGAAACGGCAGTCTAAGCAAAAAGAGAAGTCAATTGATGTCGATGACCCTGAAACAGTTGAAGAAAGCCCCAAATCGGGAGAAAGCTTAGGCGAAGATAATCTAAATGATACACCTGAAATCGTCGTAGAAGAAATAATAGATGACGACGATGAGGAAGTAAAGAACGATAGGGCAAGCAAAACCGTTGATATGACTCAAAAAGATGAGGAAGAAAAGATTAGAGAAAAGCCTGTCGACATAGAAATTAAACCTTCCGAAACAGTTAAGGTATCTTGCACGGAAGTATCGGAGAACCCTGCACCGAAAGAAAAACAAGATAAACCACCCGAAGCAAAAATACCGCCTTTGAAACGGGAACTTCCTATATCAAATAATGCTTCGGAGCTTAAAAAAGTTGTACCGGAGAAAGTTAAAAAGATCGATCACCAGCAGGTCAAAGAATCGACGAAGAAAACGCTGGCAAAAGACAAAGTGGCTCCTTCTGTGAGCAGACGGCAGAAATCCAGCGCCACTCCCCTGGCGACCGTTCCCGAGGGCAAGCCGGTCGAGTCTAGCGACGACGATGACGTGCGGTACATGCTCAATCCAGATTTCCAAGCAACCGAAACATCAGGCGAGAAAACATTCATGAAAGTGCGATCGAACAAGCGTAACTCCCTGCAAATCGAGCGCCCCAACTCGAGAGACCTCATGAAAAGGAGAACGTCCCTGCAACACCCGCCCAAGATTCCTCGGCTGAAAGCGAAAGCCGTCGAGCCAAAACTCGTGCCAACTTCGCTCACTAAAAATGACACCAAAATATCTAAATTAGAAGCCACCGCGTTTACAGATTCGGACGACAGCGACGTAAAATACTCGTTTCCAGATAAAGTGCCGCACCAATCGACAAAACCGATTCCACAAGAGAAGCCAAAGGATAAGCCCGTCAGGAAATCCCTGGTCGAGAAACGGAAGTCTCTCAGCGGCATAGCAAAGCGGAAATCGATGGGACTCAAGCTCGCCGCCAAGCTTAAACCCAACTCGCCTCCCGTCCGAGTCATTAAAAGACGAACGTTGGAGGTGGAACACCGGTGTGACTGCGGGCAGTTGTTCAACAGCGCGGCTCTGCTGACGCGGCACACGAGCCTCGCGCACACGCCGCCGCGGATACGCCGCCGCCGCTCACCGCCGCCGCCGCCGCCGCCGCCCGCCGAGACCTCACACAAAACCGCCAGGAAACTCGGCGTCAAAGGCGAACCCTCCAACTCAAACGTCAAACCGACGAGAAAGTCCAGCGTCAAGGCCGACACCGCTTCCGGGGTGCGAAACTCGAGCGTCAGGTCGGAGCTGAGCCCCGACGCGCGCAAGCGTACCGCGAAGGGGACGCAGGCGCGCGGCGGCGTGCACCGCGGCGTGCCCGTCCCGGACCGGATGCGCAAACTGATGATGAAAAACGCAAAGTAA
Protein Sequence
MDRLNQLSAGGEAGCGDSTLDTSSSPSEGFVSANESSSKYFSLSDSTFDIDPIKDVSLASVASTASEADRTMTSEDELISNLSPITKKDVMLESYKMGKQIEAANILSGGVDIFDDNDNSYDGDELVIDDNVELDEKSNLDKSDSQFKGDETAVEATLVDSPLDVASRDTEVVLQIDGNNVDAIDIGNGLYLYRKDGQEELAAVQIITEDDQQQPSFKFLKVRENAEGNLEVYEEFEIEVTKEVSAKDSKQSVKKTSHTPIKEINRVISDASSNKVTENIEKTSPKEEVSTSAKEVDTDVKEITVESKTEINFNGKMKFSESRKSPVVGSFTPMTYHSTPNKEGKPLTKTMVDLQLHPNRHSDNVKKTIEVHTDSQNKKIVTDEFHKPKLETQAMKSSTDNTITKEKISTESLEESSDVTEKSGKDPQVTDNISSCSANIKPGTDKLSHLIGDVSKKLLSPTLINVDSITKVEDIVTIDIENKQIEAETSLPKNEERHIQDTDNKDIDDPKPMSTTVDALSTTNSTHNPVLEIGSSEKIPSASKEVNTESLLTKDLFKSGSVKEVNKDATTMLESKTVDNLIVKSQAVKTNEQKEDNTICEMCPEIATSNVIDSQSPHQDSNVFHPKTHIDVILQKGSHERPDEVGVKHLQLHQTLKPLPEFSSKDSKASDKIIEENKIPIIPSVPTMEMTTSKHEFHDDNFAIVAKTVPTISPNEGESDQKSKNNTAKKDVQLNEGNKSTGSTENKSDANTDKYKQLPKAELHTVAAESACNTSLETKSSISPSNVEITTVSEIDKMIGVPKEITCKPHSVQSKTEIISSSASGPKKVLTMEKYDPVSKAPEQKAVTKTEKLIVSKDIASNLISTPESLNTVPKTEPITVGTCTTFKPVSKTESTSLVEKEIVTKAASKTEMFNPVGIKIDTKCETNVEKEIVTKAASKTKMFNPVGIKIDPKSELNVEKFNAVATDILNTKTTMDSVKSNKNYSHNKEQCTDKNETRVPEVSISGAKPMNNNHAAVPFGKWTDANRQEFLSKFKDIKIPAPSNTKQIKNSNDLNRIDVLKKIDSQRSNNASSKPQDKSTVKDTVFSNKIAPPKVTKIPVKTEGPKIKPKPETVVENNTLKQDSKIKEKSTSLVVANVGTSAEIKPGTEERRNVNVNMTNLITRTIVDMLNRPVPMTMCKSSLSEPKPRPIENTDVKVTSEESYKNSNSDVKKLDDDSSGSLDDIEMKMNELHGIPFVERPPHELPRLHKTYSKTSKDSNLAKKVQKKPIFAAPTTSIQSLTQTIIDVDSDDELIEHEPVTGDTDLNKKKLVPVIPASVKTQFTDNKTVPTSQDPQKKNPVITENDFDKFARRNSITYENCLTVKFDGKEPANVVQTVKEKDAKPCPRNEKIRVDPNTKLPCKQYTCQNVYVGNVSHIGKFGSMTEDPNSKNYQSKIATAYQSALSSKRQIDRPITIIEDKPVKVVFMDANAEFVPNQLNVQGKELSPAKKPASDVDAAVNNAQSINIDVMDAVDDSKQLDDMKTKTKHQRKQVLTPVEAPDLELIQPGEIGIDATPKKKRKTDDNKTEKNLKSPVHKKQYLLGRSNVTGEKTSDINNPEKETSRSEIVPERSAVSAIDSLVKAAELLENQSVESSSPNPDSQQSTPVKRGRGRPRKYPLPEGATDSKVASPSPQKKPRLIDAKPVKDDSVTDDNESTDEEEITRENWTMGKINENIVCPICNKLFRSENVVFKHVKHCTGVSPSRSESEKMSPRRRRHSRESDNKSFESKSDHTDVDEKLSETVIKTPTKRKSHESVTKHEGKTGHKDNEIIVSNDTPVKDQVNKILKENPENEIVVRSNKEPTNKKEISVNKLGKVKKLTKTNFRERSSDLVCEFCGKTFRQLSYLVNHKLQHRKEQKNKLETNIPANKIQVFSCEVCKKEFRKLHHLVQHRIIHNLEVPTRTLRKSSSEQTENKNGKEQATPKQNDDTSAGFRCEPCDKSFRKLHHLVEHRETHDGINRQKNTSAQAIIEKLPPPPTCEVCKKTFRKLSHLIEHKEQHVEQVETSSEKSDDKSVKSSLSTKDIIHECSLCYMVFPNEHSLNKHFVICQQKKKRQSKQKEKSIDVDDPETVEESPKSGESLGEDNLNDTPEIVVEEIIDDDDEEVKNDRASKTVDMTQKDEEEKIREKPVDIEIKPSETVKVSCTEVSENPAPKEKQDKPPEAKIPPLKRELPISNNASELKKVVPEKVKKIDHQQVKESTKKTLAKDKVAPSVSRRQKSSATPLATVPEGKPVESSDDDDVRYMLNPDFQATETSGEKTFMKVRSNKRNSLQIERPNSRDLMKRRTSLQHPPKIPRLKAKAVEPKLVPTSLTKNDTKISKLEATAFTDSDDSDVKYSFPDKVPHQSTKPIPQEKPKDKPVRKSLVEKRKSLSGIAKRKSMGLKLAAKLKPNSPPVRVIKRRTLEVEHRCDCGQLFNSAALLTRHTSLAHTPPRIRRRRSPPPPPPPPAETSHKTARKLGVKGEPSNSNVKPTRKSSVKADTASGVRNSSVRSELSPDARKRTAKGTQARGGVHRGVPVPDRMRKLMMKNAK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-