Basic Information

Gene Symbol
ZFX
Assembly
GCA_947359385.1
Location
OX375783.1:1978715-1992395[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.016 0.91 10.2 1.1 2 23 260 281 260 281 0.94
2 12 0.64 36 5.1 0.0 1 22 286 307 286 310 0.92
3 12 0.97 55 4.6 4.2 2 23 429 451 428 451 0.84
4 12 0.00059 0.034 14.7 0.0 1 23 457 479 457 479 0.95
5 12 0.017 0.99 10.0 0.2 1 23 488 511 488 511 0.92
6 12 4.5e-06 0.00025 21.3 5.7 1 23 516 538 516 538 0.98
7 12 5.9e-05 0.0033 17.8 2.9 1 23 544 566 544 566 0.97
8 12 2.8e-05 0.0016 18.8 2.0 1 23 572 594 572 594 0.97
9 12 2.3e-08 1.3e-06 28.6 0.3 1 23 600 622 600 622 0.98
10 12 0.00066 0.037 14.5 3.4 1 23 628 650 628 650 0.99
11 12 3.9e-05 0.0022 18.4 0.9 1 23 1019 1041 1019 1041 0.98
12 12 8.7e-07 4.9e-05 23.6 1.6 1 23 1047 1070 1047 1070 0.96

Sequence Information

Coding Sequence
ATGGAAGTTGTTCTGTATAATTCTACTGTGTGCCGATTATGTGGAGAGGAAAACGATAATGGAACATTTTTATATTCAACTGAAGAAAATAACCAGAACATTAGTGATTTAGTGAACACATATTTACCAATCAAGGTGTCCGATGATGGACAGCTTCCGCGAACCATTTGTCCAGGATGTACTATCCAACTTGAAGCCACAGTCGAATTCATTAACTTGATAGTTACTGGTCAGAAAACTATTAGAAGTCTCTATCAGAGGGAGAGAGAATACAAGAAAAAATTAAATAAAGAACCTAACTATGAAGTACCCAGGAGCATTTTTGTTGAAGTGGGTCCGGCAAACAGGGCATACGAAGAGGCGCACCCCATCTCCCTGCAGGTGGCCGGGCTGGACAAGCCGAAGCGCAAGCGCGGGCGGCCCCCCAAGCAGGCCCAGCCCCCGGACGAAGTGGCGCAGGCCGCCGCCAGGCAACTGGAGCTCGACATGAGGAAGAGAGACCAAGAGCCCACCGGCAAGAGGAGAAGGAAAACTCCAGAGAGATTTAGAGAAGTTGTACAGGGTAAAGAACTTGAAAAAATATTCAAAGAGGAAGGCGTGACGGACGGTGAGGAAAGTGAAAACGATGCTAAAGTTAACACCAAGAGCATGTCTTCCGAGGACCAAATTCCAAAGGTGCCCGAAATAATCGGTCACACTGAGTCGGGAGAACTGGTCGTTGTGGTCAAGGGCAAGGGAAGAGGCAGGCCTAAAGGGCGCACGCGTCAAACGCAAGAGACGTGCGGCATATGCGGCAAATACTTCTCTAACTGTGGGCGGTACATGTCGCACGTGGCGCAGCACGGGCCCGTGGTGTACCAGTGCGTGCGCTGTCTCGCCACCTTCCCCATCCGGCTGGAGCTCAACGCGCACCAGCGGGACGCGGGCCACCAGGGGTACAGCGTGCGATCCGCCGCCCTCGACGACACACACACACACGTTGATACACCCCGCGAGAACGCAGCTGTAATAAAGCCGGAGCCGCTCGCGTCCGCCCCGACCGAGATATACATCACGTCGGACCTCCCGGGGGACAAAGTGTCAGACGGGGGCGCCGGCGCCGGCGCCGGGTCCATGCCGGACCTGAGCCCGCACCCCGTCCAGTTGAATGTCGCCAATGAGTTCCTTAAGCCGCCCAGTATGGACGCCGATGGTGGAAATGAGACTGAATTGGAAAAAGAATTAACAAAAAGCGACAGCAAGACAAAAGAGCCAGACGAGCAAGCCAAAAAGAAGCACAAGTTGAAGTGTCCGCACTGCGACAAGAAGTACAGCTGCAAGCAAAGCAAGTCGATGCACATCAAGGCAGCGCACAAAGGTGAGCGTCCGTACATCTGCAACGAGTGCGGTGTTTCGTTCGCGTACCCGCGCGCGCTCACGCTGCACGCGCTCGCGCACCGCGCCCGACACTCCACCAAGGGGTTCGCGTGCGACCTCTGCGGGAAGGTGTTAAACCACCCGTCGTCGGTGGCGTACCACAAGCAAGCTGAGCACGCGAACCAGCGGTACGTGTGCAACAAGTGCGGGAAGCACTTCAAGCACAAACAGCTGCTGCAGCGGCATCAGCTCGTCCACACGCAGAACAGACCGTTCTGCTGCAAGGTGTGCAACGCGAAGTTCAAAACGAAAGCAAACCTGATCAACCATCAGATGCTCCACACGGGGATCAAGAAGTTCGCGTGCGAGGAGTGCAAGCAGCGGTTCGCGCACAAGACCAGCCTCACGCTGCACATGCGCTGGCACAGAGGTCAAAAGCCGTTCGTGTGCAAAGTATGCGGCAAGGCGTTCACACAGAAAGGCAACCTGTCGGAACACATGCGAATCCACACCGGAGAGAAACCGTTCCAGTGCGCGATCTGTCCGCGCAAGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGTTCACCACCTCCTCGCAACACAGACTGCACCTGCGGAGACACGAGCCCAGGCACAACAGGCTGCAACCGATAAGAACATTATCTTTCGAAGACACCACAACAACGATCGTGAACAACGACGGCAGCGTCACACAGATCACCATTAATACAAGCACCGACACTGGTAGCGGTGGTAGCGCCACCTTTACGGGTACTTCTGCCGGCGGGCAGAGCAGGCGTCCTGGTAGTTCTCAGGGGAAGGTCGGTCATAAGTGCGGGTTGTGCGGCCGCGTGTCCTCCACGCGCTGGGCGCTGTCGAAGCACATGCGGCTGCACACGGGAGAGAAGCCGTTCTACTGCCCGCATTGCCCGCGGACTTTCGCTGACGCTTCTAACCTCAATAAGCATAAAAAGCAAGTGCACAAGCAAACCTCTCTGCTTGCTGTGCAACCGTTCGCATCGGCGGCAAACAAGCCCCCGGGGCCGCCGCCCCTGCTTTCTCCCCCGACCCCGACCCCGACCCCGGCCCCGGGGCAGGGACAGGGGCAGGGGCAGGGGCAGGGGCTGGGGCAGGGGCTGGTGCCGGAAGAGTTCGTCGTAGAGTCCACCGCGGACGATGACGACGAGCGGGTGatatacgtcacatacgacgtcgacgagcagccctcgccgtaccagatgctggacgccgcacagACGGAGGAGGTATCGTGCAAGTCTGAAGAGGTTTACAGTGCGGACGAGGCGTGTTCGCTGTACTCGCGCGACTCGCTGCTGCTGCCCAAGTCGCAGGACGAGCCCGTACATATGTCGgtgacTGACGAGGAAGGCAACCCGCTGCACTTCACGATGCAGGACGGAACGAGGCTCGCTATTACCTCCCTCGACGGACACTCCTTGCAGGTGATCACACAAGACGGACAAACAATACCGGTTGAAATTAACGGGTTCACTCCTGATGGGGAATTTAATATTGAACAACCGAATCAGGATGTATCAGAGGAGGATCTGGTAGTCGCCAAGGAAGAGCCTGACCCCGACTCGCCCGTCACGCACTACTACACCATAGTATAG
Protein Sequence
MEVVLYNSTVCRLCGEENDNGTFLYSTEENNQNISDLVNTYLPIKVSDDGQLPRTICPGCTIQLEATVEFINLIVTGQKTIRSLYQREREYKKKLNKEPNYEVPRSIFVEVGPANRAYEEAHPISLQVAGLDKPKRKRGRPPKQAQPPDEVAQAAARQLELDMRKRDQEPTGKRRRKTPERFREVVQGKELEKIFKEEGVTDGEESENDAKVNTKSMSSEDQIPKVPEIIGHTESGELVVVVKGKGRGRPKGRTRQTQETCGICGKYFSNCGRYMSHVAQHGPVVYQCVRCLATFPIRLELNAHQRDAGHQGYSVRSAALDDTHTHVDTPRENAAVIKPEPLASAPTEIYITSDLPGDKVSDGGAGAGAGSMPDLSPHPVQLNVANEFLKPPSMDADGGNETELEKELTKSDSKTKEPDEQAKKKHKLKCPHCDKKYSCKQSKSMHIKAAHKGERPYICNECGVSFAYPRALTLHALAHRARHSTKGFACDLCGKVLNHPSSVAYHKQAEHANQRYVCNKCGKHFKHKQLLQRHQLVHTQNRPFCCKVCNAKFKTKANLINHQMLHTGIKKFACEECKQRFAHKTSLTLHMRWHRGQKPFVCKVCGKAFTQKGNLSEHMRIHTGEKPFQCAICPRKFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRFTTSSQHRLHLRRHEPRHNRLQPIRTLSFEDTTTTIVNNDGSVTQITINTSTDTGSGGSATFTGTSAGGQSRRPGSSQGKVGHKCGLCGRVSSTRWALSKHMRLHTGEKPFYCPHCPRTFADASNLNKHKKQVHKQTSLLAVQPFASAANKPPGPPPLLSPPTPTPTPAPGQGQGQGQGQGLGQGLVPEEFVVESTADDDDERVIYVTYDVDEQPSPYQMLDAAQTEEVSCKSEEVYSADEACSLYSRDSLLLPKSQDEPVHMSVTDEEGNPLHFTMQDGTRLAITSLDGHSLQVITQDGQTIPVEINGFTPDGEFNIEQPNQDVSEEDLVVAKEEPDPDSPVTHYYTIV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-