Basic Information

Gene Symbol
-
Assembly
GCA_949126925.1
Location
OX421361.1:9036076-9065623[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 3.6 4.5e+02 2.4 1.3 3 21 622 640 621 644 0.92
2 15 0.0065 0.81 11.1 0.5 2 19 666 683 665 686 0.92
3 15 0.19 24 6.5 0.6 1 23 703 727 703 727 0.93
4 15 0.53 67 5.0 0.3 1 23 732 756 732 756 0.90
5 15 5.2e-05 0.0065 17.7 1.8 2 23 828 850 827 850 0.96
6 15 0.07 8.8 7.8 0.9 1 16 855 870 855 877 0.86
7 15 0.66 84 4.7 0.2 1 23 897 919 897 919 0.93
8 15 0.00035 0.044 15.1 1.6 2 23 933 953 932 953 0.97
9 15 3.6e-05 0.0045 18.2 2.1 1 23 959 982 959 982 0.96
10 15 1.9e-06 0.00024 22.2 1.8 1 23 998 1020 998 1020 0.98
11 15 0.52 66 5.1 0.1 1 23 1027 1051 1027 1051 0.94
12 15 0.01 1.3 10.4 2.4 1 23 1057 1081 1057 1081 0.98
13 15 0.0016 0.2 13.0 0.5 1 23 1088 1110 1088 1110 0.99
14 15 0.0028 0.36 12.2 2.1 1 22 1116 1137 1116 1141 0.94
15 15 1.6 2.1e+02 3.5 0.2 1 23 1147 1174 1147 1174 0.86

Sequence Information

Coding Sequence
ATGCTCGAGGAGGACCTCGATGATACACACTTGTGCATCAAGTGTAGCGCCACAATTGTCGGCCTTGATAATTACATTCAACATCGCAAAACGAATTGTGGCAGCAAGGCGACGGCAGCCGGCTATGGGGAGTTTGAGTATCCGGATGCGGCGAACTACACCAAGACTGAGGTGGAGGCCGGAGCAGAGAAGGCTTCCAAGAGCTTGAACGACCCGTATGACTTGCCCTACGAACTGGGTGCAGATGTGTTCTTCTCCTCGCTGCAGTTGCAAAGCGTGCAGGCGAGCTCTGGCGGCAAGGCCAGTAGTGCCCAGCAAATATTGACAAGGAAGGCCACAGCGACGTTGCTGACTTCGGGGCGGGATGAGGCCGGCGGTGGAGACTGGCAGGAGGAGGCACCCACCAACAACACAGACAACCTGATGAAGGTTGTGCGGGATATTGGTGAGACGAAGAAATTTGAGCCCGTATTCAAGCCGATTGCCTTTGCGCATGGGTCGCCCGAACCGGACCAGAGTGACGACGAGGACGACGAAGATGAGGACTTcgaagacgatgatgatgacgacgaagaCTACGTACCGACACCGTACAGTGGGGGCAAGTGGAAGCCCGGCAGTCAGCCTGCAGCTAGGAGCGGCGGCAAGTGGAAAAGTCGAACGCAAGCAGTGGCTCCCATTCCATCGACTTATACGGGCGGGAAGTGGAATTTCAAGTCTTCTAAGAGCAAAAATGTAGACAAACGACCGCCGGAGACCTCATCCGACAGGCTGTTGTCAGAGATACGGGCGAAACTGAAGACCTCCTGTGGCTATACCCCAAAAGAAGCTGTCGAAGGATTTGCGATGCCAGACACCGTCCCCGAAGCTGGTGGTAAATGGAAACCGGGGTTTTCCAAATTTCCCATAAGTGTCAAGTGGAAGCCCGCCGATGGTCAGGAGTCACCGGAAGTTCTGGAGGCCCAAACAGGCGGCAAATGGAAGCCTGGCCAAGGACCAGTATCTGGTGACAAATGGAAGCCCGGTGGGTCGAAAACGCTGAAGCTCTTTCTTCCTCCAGTAACTGGTGTAAAGTGCAATCCGCACGAGGGAAACCAATCGCCGGAGATCCTGGAAACACAGACCGGTGGAAAGTGGAAGCCCGGGCAAGGGCCGGCAACGGGCGGCAAGTGGAAACCAGAAGATCGACCACCAGATTTGAAGCCCTCACAGGAACCAGAGCCGGAGCCACCAGCCTGGGACAATCAAGAGCCGTGGGGAGAGGATGCCGGCGAGGGCCACCCCCCACTGGAGCACACCAAAGGCAAGTGGATGCCAGGAGCAAAGGTCGAGCGGCTTGAGTACAAAGAAGAGgcccTTCCACCACCGCAGGACTTCTGGTGCAACATCTGCTGCCGCAAGCTGAAGACCAAGACCATCTACGAGAAACACCTCAAGTCGGGCGTTCACTCGCGAAAGTCCGAAACCGAGCAGCAACTGGAACGTGCTGCCGTCGAGCAGCTAGAACTGTCCCACCAAATCCTGCGACCACCTGCCTTACTCCTGAAGCGATCCGCCTCTCCCGAGCCGGACCCTGGAAAGCGAAGAAGACGCAAAACTTTTATAAAATGCGAAATATGCAAACACCGCATGCAGCGCTACCTGGTGGGCAAACATCTTATCTCACACTACCACTACGTGCGCATGAGCCTCAACCCGAAACTCTCCTTTGGCATGGTCCTCGACAACATCCATGCGATAGTGCGGCAGGCGCCGTTCCAATGCAGTCCGTGTCGGTTCTACGCCAACACCGAGGAGAACTTCCTCAACCACTGGAACTCGCCCGACCACCGCGATAGGACCGAAGGCCCAGGCAAATTCTGGTGCAGCTTTTGTCGTTTCGAGTGCGAGGACAACAATCAGATGAGGCGTCACCTGCTCGGCGCCGATCACGGCGAAGTCATTCTGGCGATCAATCGGTCGGTGCCGATCTGCATCAGCAAGAAGGTGGCCATCGAGTGTCCGAAGTGCCATCAGGGCTTCCGCTTCAACATGGAACTGCGGCAACACTCCCTGCGGTGTGACAGTGCCAAGGGTGGCACTGCCTCGGACGAGTACCAGTCGCGGTATCGCTGCAAACTCTGTCCCGATGAAGTTCTGAAGTCAAAAGTCGCCCTACAGAGGCACGAAAAGTTCAAGCACAACCAGAGGCGGTACTACTGCTCCCTGTGCGAGTTGGACTTTGAAAACGCTGTTAAGGCTGTGAAGCACCGAAAATCGAAGGCGCATAGAATCAAGTCCGCTGAGAAAATGACCCGCCCCCAGAGGGAGGCCGCGAATCCCATGCCCAGGGATGAGATCGCCGACGATCTGCGGTGTGACAAGTGCAATCATTTGTCCTCGTCGGACGTTGAGGCTATGCTGCATCAAATCACCCACCCCGACGGTTGCACCAAGAAGACCGCCGAACCGCCAATTGAAGCCACACTCAACGGCTGCCAAAAGTGCACCCACTGTGTCAAGGCGTTCAACTCGAAAGCCGATCTAAAATCACACCTAAACTCTGCCCATCCGGAGATAAAGCACGTGTGCCCACTATGCGGAGAGTCCTTCACCCTGCCCCGCGAGCTCGGCTGTCACAAAAGGTACAAAATGTGCGTGCCGCAACCACCCACCGAATCCACTTCAAATCTGGCTGTGAAAAAATCCTTTCCATGCTCCGATTGCACTTTTAGCTCCGCCTATGAGTCGGAGCTCATATTCCATCGGATTATCCATACCGAGGGTGTGGAGGCGCTCAAATTGAATGCAAAGCTGAAATGTCCACTCTGCGAGAGATCCTTTTCCAAGTACTCACTCCGGTATCACTTGCGCCAGCACACCAACGAGAAAATGTTCGTGTGCGAAATCTGTAATGGGTCATTCTCCCGCCGGCACAATTACAAGGATCACATGCAGTACGTACACGGCGTTGGGGGCGAGAAACAGCGAAAGCCTCGTCGGAGCGAACGTTTCGAGTGCGACACATGCGGCAAGTCTTTTACCGCCAAACACACTCTGCAAATGCACATGAACGTTCACATGGGACGTGATAAGAAGTTCATGTGCACCATGGAGGAGTGTCAATATATTGGACGGAATGAAAGGGCTTTGAAAATGCACATAGCCGCGCATGCCCTGAAGATGGACTTTGAATGCCCGGAGAAGGGCTGCACCTACAGAGGGAAGACCGAGCACTATCTGAAGAGGCACCGGAAAGTCCATATGGACATTGACAAAGTCTACAAGTGTCCTGAATGCGATTTTAAGGCGAAGCTTCCAGCTCACATCAGGCGTCATGTTCGAGTGCACACCGGAGAGTGTCCCTTTAAGTGTCCGCATTGTGACTACAAGAGTGGGTATATTGAAAACCTACGCAAGCATATTCTGACTACGAAGAAACATCCGGGGAAGTTCATCTATCAATGCGAGAAGTGCGATTCATCGAATCCGTATAGAACTAATTTCAGTGCGGACTATCAGGTGCATTTGATATCGGCGCATCCGTCCGGATAG
Protein Sequence
MLEEDLDDTHLCIKCSATIVGLDNYIQHRKTNCGSKATAAGYGEFEYPDAANYTKTEVEAGAEKASKSLNDPYDLPYELGADVFFSSLQLQSVQASSGGKASSAQQILTRKATATLLTSGRDEAGGGDWQEEAPTNNTDNLMKVVRDIGETKKFEPVFKPIAFAHGSPEPDQSDDEDDEDEDFEDDDDDDEDYVPTPYSGGKWKPGSQPAARSGGKWKSRTQAVAPIPSTYTGGKWNFKSSKSKNVDKRPPETSSDRLLSEIRAKLKTSCGYTPKEAVEGFAMPDTVPEAGGKWKPGFSKFPISVKWKPADGQESPEVLEAQTGGKWKPGQGPVSGDKWKPGGSKTLKLFLPPVTGVKCNPHEGNQSPEILETQTGGKWKPGQGPATGGKWKPEDRPPDLKPSQEPEPEPPAWDNQEPWGEDAGEGHPPLEHTKGKWMPGAKVERLEYKEEALPPPQDFWCNICCRKLKTKTIYEKHLKSGVHSRKSETEQQLERAAVEQLELSHQILRPPALLLKRSASPEPDPGKRRRRKTFIKCEICKHRMQRYLVGKHLISHYHYVRMSLNPKLSFGMVLDNIHAIVRQAPFQCSPCRFYANTEENFLNHWNSPDHRDRTEGPGKFWCSFCRFECEDNNQMRRHLLGADHGEVILAINRSVPICISKKVAIECPKCHQGFRFNMELRQHSLRCDSAKGGTASDEYQSRYRCKLCPDEVLKSKVALQRHEKFKHNQRRYYCSLCELDFENAVKAVKHRKSKAHRIKSAEKMTRPQREAANPMPRDEIADDLRCDKCNHLSSSDVEAMLHQITHPDGCTKKTAEPPIEATLNGCQKCTHCVKAFNSKADLKSHLNSAHPEIKHVCPLCGESFTLPRELGCHKRYKMCVPQPPTESTSNLAVKKSFPCSDCTFSSAYESELIFHRIIHTEGVEALKLNAKLKCPLCERSFSKYSLRYHLRQHTNEKMFVCEICNGSFSRRHNYKDHMQYVHGVGGEKQRKPRRSERFECDTCGKSFTAKHTLQMHMNVHMGRDKKFMCTMEECQYIGRNERALKMHIAAHALKMDFECPEKGCTYRGKTEHYLKRHRKVHMDIDKVYKCPECDFKAKLPAHIRRHVRVHTGECPFKCPHCDYKSGYIENLRKHILTTKKHPGKFIYQCEKCDSSNPYRTNFSADYQVHLISAHPSG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00312116;
90% Identity
iTF_00314781;
80% Identity
-