Basic Information

Insect: Cheilosia vernalis
Gene Symbol: run
Assembly: GCA_949126925.1
Location: OX421360.1:45022390-45025369[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.4e-71 1.2e-67 226.2 0.0 2 129 54 181 53 181 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.4e-71	1.2e-67	226.2	0.0	2	129	54	181	53	181	0.99

Sequence Information

Coding Sequence: ATGCATCTGCCCCAAGGACCAACAGTCGTTGCAGTGCAACCACCCACCTCGAATAATTCGCCACACCGCAGCAACGACACATGCCAGTCACAGGATAATAGCACATCAGCGCCCGCCGCCAAGATGCCCGCTTCAATGACAGACATGTTCGCCAGCCTCCACGAAATGCTCCAGGAATACCACGGAGAGCTGTCACAAACAGGATCACCATCGATATTGTGTTCGGCGCTGCCGAATCATTGGCGAAGCAATAAGTCTCTGCCGGGAGCCTTCAAAGTGATCGCCTTGGACGATGTTCAGGACGGCACCTTGGTCACCATCAAGTGCGGCAACGATGAGAACTACTGCGGCGAACTGAGGAACTGCACCGCGATAATGAAGAATCAGGTTGCGAAATTCAACGATCTGCGGTTTGTCGGACGAAGCGGCCGCGGAAAATCGTTCTCGCTCACCATCACTATTGCCACATATCCCGTGCAGACCGCCTCCTACAGCAAGGCCATCAAAGTGACCGTTGACGGTCCCCGCGAGCCACGATCCAAGCAAAATTATGGATATCCCCATCCAGGAGCATTCAATCCATTTATGCTAAATCCTGCGTGGTTAGATGCAGCCTACATGACATACGGATATGCGGATTATTTCCGTCATCAGGCGGCGGCTGCAGTCCATCATCCTTCGATGGCAAAAGGATCTCCAACACTCCCACAGACAGGGCCGACAACCGTCCTCCCACCGTCATCAGTGCCACAACCACTTCCCCATGGCGAACGCCATCCGAACGACTTCCACGCCGCACCAAACACACCGCCAGGGCTGCCGCCAATGTCCGGTCCCAATGGCCTTATACCATCACCCGGATCGGCGGTCAGCAATGGAGCCTACCTGCCGCAATTTCCCTTCGGACCCGGCCAACCATTCCTGCCGTACAACTTCCCCGGTTTGCGTGTTCGCAACGGTCTTCCAGCACACGGCGGCAACCCTCTGAACACATCACTCGGCAGTCACGGTTCAACGGAACACATCAGCCCGGCACACATATCACCAGCATCGTCGCGCCCCTCATCGTCCAGCCCGCCCTCCACAAACCACAGTATCTCTGCGAAGCTGAACACATCCCTGGAGACGAGTTCCCTGCACGAGCAATCATCCGATGACTCTGATGACGAGCAAATCGACGTTGTCAAATCCGCCTTCGACGACCTCGACAAATCCATCGACTCGACCCGCAGCAGCCCGCTAAGCACGATTCAACAATCGGCGCCTCGACTGCGATGCGACCTGAAAGCACCATCGTCCATGAAACCACTGTTCCACGAAGCGCCCCGTTCTACACCCACCTCACCCGAAACCAAGCTCAAAGCGTCCACAATATCGGCTCAGAAAACCGTCTGGAGGCCGTACTGA
Protein Sequence: MHLPQGPTVVAVQPPTSNNSPHRSNDTCQSQDNSTSAPAAKMPASMTDMFASLHEMLQEYHGELSQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVQDGTLVTIKCGNDENYCGELRNCTAIMKNQVAKFNDLRFVGRSGRGKSFSLTITIATYPVQTASYSKAIKVTVDGPREPRSKQNYGYPHPGAFNPFMLNPAWLDAAYMTYGYADYFRHQAAAAVHHPSMAKGSPTLPQTGPTTVLPPSSVPQPLPHGERHPNDFHAAPNTPPGLPPMSGPNGLIPSPGSAVSNGAYLPQFPFGPGQPFLPYNFPGLRVRNGLPAHGGNPLNTSLGSHGSTEHISPAHISPASSRPSSSSPPSTNHSISAKLNTSLETSSLHEQSSDDSDDEQIDVVKSAFDDLDKSIDSTRSSPLSTIQQSAPRLRCDLKAPSSMKPLFHEAPRSTPTSPETKLKASTISAQKTVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00312364;
90% Identity: iTF_00313222; iTF_00314042; iTF_00310783; iTF_01253315; iTF_00312364; iTF_01299796; iTF_01300588; iTF_01541206; iTF_01541936; iTF_00389394; iTF_00311579; iTF_00724543; iTF_00309994; iTF_00314923; iTF_01223163; iTF_01520746; iTF_01522339; iTF_01521652;
80% Identity: -