Basic Information

Insect: Cheilosia variabilis
Gene Symbol: topi
Assembly: GCA_951230905.1
Location: OX579676.1:10088660-10091069[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 3.7e-05 0.0052 18.0 2.8 1 23 208 230 208 230 0.97

2 10 0.76 1.1e+02 4.4 2.8 2 23 257 278 256 278 0.93

3 10 1 1.4e+02 4.0 0.1 2 19 333 350 332 352 0.93

4 10 0.03 4.2 8.8 1.0 1 22 400 421 400 424 0.90

5 10 0.016 2.3 9.6 0.1 2 23 439 461 438 461 0.86

6 10 4.3e-07 6e-05 24.1 2.0 1 23 476 498 476 498 0.95

7 10 0.0017 0.24 12.7 0.9 1 23 504 529 504 529 0.95

8 10 0.38 54 5.4 1.6 1 23 535 557 535 557 0.88

9 10 5.4e-07 7.6e-05 23.8 0.2 3 23 565 585 563 585 0.98

10 10 0.0066 0.93 10.9 1.2 3 23 593 614 591 614 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	3.7e-05	0.0052	18.0	2.8	1	23	208	230	208	230	0.97
2	10	0.76	1.1e+02	4.4	2.8	2	23	257	278	256	278	0.93
3	10	1	1.4e+02	4.0	0.1	2	19	333	350	332	352	0.93
4	10	0.03	4.2	8.8	1.0	1	22	400	421	400	424	0.90
5	10	0.016	2.3	9.6	0.1	2	23	439	461	438	461	0.86
6	10	4.3e-07	6e-05	24.1	2.0	1	23	476	498	476	498	0.95
7	10	0.0017	0.24	12.7	0.9	1	23	504	529	504	529	0.95
8	10	0.38	54	5.4	1.6	1	23	535	557	535	557	0.88
9	10	5.4e-07	7.6e-05	23.8	0.2	3	23	565	585	563	585	0.98
10	10	0.0066	0.93	10.9	1.2	3	23	593	614	591	614	0.95

Sequence Information

Coding Sequence: ATGAATTGTGATGATGAATTCAATAACTCGGAAGCATGGCTGGCTGAACAAATATTTTCACAGCTCAAAGATTTTAAAACGGAGCCTGTAAAGGATGAGGAGGAAAACAGCAAACTGACTTTTGATACGCTGGACTCTCTAAATTTGGATGAAACTTTTAGCTCAAGCAATGTTCTAGATTTGAGTGCACCTGAGGTGGATGAGGATATCAACAAGGAAGCCCAAGCAGAGAAGGAAAACGGTTGTGCAACGTTAGATAATTCACAGCAACAATTCCATGGGCCTGAGAAAGATGTTGTTAACCAACAAAACGAGGACTTGCTTCAATATTTTGATGCGCCGTTTCACGTCCCACAAAACATTGTGGAGTGCGCAAACTGCAACTGCATTTTTGAAGCTGATTCCTTTCCCGAACATATCTGTGACTATGGTGAAGATAAAACACTGATTATTCCGGAACCTCTGGAACCATCACTGTCATCCTATCATGCTGGTCCTGTTGAGCCTCCGTGCGTGCGATTGTTGCGCGAAAATCAAATCCGCATTCGTCGTTTTCTCAAAGATGAATTGAAATACGATGTGAATGCCGGATCTACAACCACAAAGAAGCAAGAAGGTCCACATGAATGCAGCTTGTGTGAGAGGAAGTTTGTCCATGCTTCGGGGTTGTCCCGGCACATGGAAAAACATGCTCTTGATCTCATACCATCCTCATCTTCGCATGCGAACAATGGGTATCCACCTATTAACGGCTTAAAAGTAGTTATTAAATGTACGATATgtggttgtatattttttgaGGCGGAGACCGGATTTAAGCACATGTGTTTGCACTTTCCCGAAACAGATGAAGCCGAAGTGGATTTCGGGGACATTACAGAGTTTCCCTATGAGAACTATCTAGACGATGCTCTAAATTTTCTAAAGATCGAATCGAAAAATTGCGATACTAAGCCCACCGCCTACCTGAAGATGGTTATTTTAAGTTGTGTCTTGCAATGCGAATTTTGTGACCTTCTCTTCTCCGaggtttcgtttttgtttgccCATTCTGCATGCCACCAGCCACAGCGACCGTTTGAATGTTCTGCATGTGAGATTTGGGTGTCTACTGCGAAGGAGGTCTTTATGCACTGGCAGGCTGAGTGTGTGTTTGCGAGAGAGAATTTAAAACGTGGTTGCTCTGCACAGCGGTATTTTGTGTGTAATGTATGTGAGAATAAGTTTGGCTCTCTGGAACAGTTACATGAGCATAGGTACACAGCTTACCACTTCTTTCCGAGAAGAGATCGAAGCAGAGGAGTACTGATGCTACCTTGTGAGTACTGTGATCAAGTTTTTGAAACTGCAAATGACATTGTGAATCACTTTGAAGAGCGTCACTATAAGAAGAACAAACGAGATACTGGCGCTAAGTCCCGTCAATATTTATGCGATATCTGCGGAAAGACGTACACACAATCTAGTCATTTGTGGCAGCATTTGCGATTTCACAAAGGAGTTAAACCATTTGCCTGCAAGGTGCCAGGATGCTCGCGTCGATTTACAATCCGTCCTGATTTGAATGACCACATCCGCAAGTGTCACACCGGTGAACGTCCTTACCATTGTCTTATCTGCGGCAGACGCTTCCTAACCGGATCGGTGTTTTATCAACATCGCCTCATTCATCGTGGCGAGCGTCGTTATGGATGCGATGAGTGTGGAAAACGATTTTACCGGGCCGATGCGTTAAAAAATCATCTCCGCATTCACACTGGCGAAAAGCCGTACGGGTGTCTCTTTTGCACAAAAAGTTTCCGCCAAAGAGGAGATCGAGACAAACACATCCGAGCAAGACACTCCAGTTTAGATGCAAAGTCGCGTCTAATGATGCAAATGCGCAAGTTGCAACTAGAAGCGGCCGCCAAAGCTAGAGCCGACCCCTCATCGGCGACGCCAGCAGATGAGGTGCTGATGTTCGGTAACATTGCATTTCCGAAGAGCATGTTTCAGCCGATGTTAGCGGACATCGATGCAGGCCAAGACTAA
Protein Sequence: MNCDDEFNNSEAWLAEQIFSQLKDFKTEPVKDEEENSKLTFDTLDSLNLDETFSSSNVLDLSAPEVDEDINKEAQAEKENGCATLDNSQQQFHGPEKDVVNQQNEDLLQYFDAPFHVPQNIVECANCNCIFEADSFPEHICDYGEDKTLIIPEPLEPSLSSYHAGPVEPPCVRLLRENQIRIRRFLKDELKYDVNAGSTTTKKQEGPHECSLCERKFVHASGLSRHMEKHALDLIPSSSSHANNGYPPINGLKVVIKCTICGCIFFEAETGFKHMCLHFPETDEAEVDFGDITEFPYENYLDDALNFLKIESKNCDTKPTAYLKMVILSCVLQCEFCDLLFSEVSFLFAHSACHQPQRPFECSACEIWVSTAKEVFMHWQAECVFARENLKRGCSAQRYFVCNVCENKFGSLEQLHEHRYTAYHFFPRRDRSRGVLMLPCEYCDQVFETANDIVNHFEERHYKKNKRDTGAKSRQYLCDICGKTYTQSSHLWQHLRFHKGVKPFACKVPGCSRRFTIRPDLNDHIRKCHTGERPYHCLICGRRFLTGSVFYQHRLIHRGERRYGCDECGKRFYRADALKNHLRIHTGEKPYGCLFCTKSFRQRGDRDKHIRARHSSLDAKSRLMMQMRKLQLEAAAKARADPSSATPADEVLMFGNIAFPKSMFQPMLADIDAGQD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00312121;
90% Identity: iTF_00316312;
80% Identity: -