Basic Information

Insect: Cheilosia soror
Gene Symbol: topi
Assembly: GCA_948107745.1
Location: OX443562.1:105792789-105795215[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 4e-05 0.0047 18.0 2.8 1 23 207 229 207 229 0.97

2 11 0.44 51 5.3 0.6 2 23 256 277 255 277 0.94

3 11 1.2 1.4e+02 3.9 0.2 2 19 332 349 331 351 0.93

4 11 1.3 1.5e+02 3.8 0.2 1 20 359 378 359 380 0.88

5 11 0.01 1.2 10.4 0.8 1 22 399 420 399 423 0.90

6 11 0.019 2.2 9.6 0.1 2 23 438 460 437 460 0.86

7 11 4.6e-07 5.4e-05 24.1 2.0 1 23 475 497 475 497 0.95

8 11 0.0019 0.22 12.7 0.9 1 23 503 528 503 528 0.95

9 11 0.41 48 5.4 1.6 1 23 534 556 534 556 0.88

10 11 5.9e-07 6.9e-05 23.8 0.2 3 23 564 584 562 584 0.98

11 11 0.0071 0.83 10.9 1.2 3 23 592 613 590 613 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	4e-05	0.0047	18.0	2.8	1	23	207	229	207	229	0.97
2	11	0.44	51	5.3	0.6	2	23	256	277	255	277	0.94
3	11	1.2	1.4e+02	3.9	0.2	2	19	332	349	331	351	0.93
4	11	1.3	1.5e+02	3.8	0.2	1	20	359	378	359	380	0.88
5	11	0.01	1.2	10.4	0.8	1	22	399	420	399	423	0.90
6	11	0.019	2.2	9.6	0.1	2	23	438	460	437	460	0.86
7	11	4.6e-07	5.4e-05	24.1	2.0	1	23	475	497	475	497	0.95
8	11	0.0019	0.22	12.7	0.9	1	23	503	528	503	528	0.95
9	11	0.41	48	5.4	1.6	1	23	534	556	534	556	0.88
10	11	5.9e-07	6.9e-05	23.8	0.2	3	23	564	584	562	584	0.98
11	11	0.0071	0.83	10.9	1.2	3	23	592	613	590	613	0.95

Sequence Information

Coding Sequence: ATGAATTGTGATGATGAATACAATAACTCAGAGGCATGGCTggctgaacaaatattttcacagcTTAAAGATTTTAAAACGGAGCCTATTAAGGATGACGAGGAAAATGGCAAACTGACTTTTGATCCGCTAGACTCCTTGAATTTGGATGAAACCAATAATGTCCTCGACTTGAGTGCACCTGAGGTGGATGAGCACATCAACAAGGAGAAGGaaccccaaacgaaaaaagatAACGATTTTGCAGCGTTAGATATTTCACAGGAACAATTACATTTACCTGAAACAGATGTTGATAACCAGGAAACCCAGAACTTATTTCAATATCTTGATCCACCGTTTCATGTTCAGCAAAACATTGTGGAGTGCGCAAACTGCAACTGCATTTTTGGAGCTGATTCTTTTCCCGAACATATCTGTGACTATGGTGAAGATAAAACACTGATCATTCCCGAACCTATGGAACCGTCAATGTCGTCCTATCATGCTGGACCAGTTGAACCACCGTGCGTGCGATTGTTGCGTGAAAATCAAATACGCATCCGTCGCTTTCTCAAAGATGAATTGAAATACGATGTGAATGCCGGCACTACTACCACGAAGAAGCAAGATGGCCCCCATGAATGCAGCTTGTGTGAGAGAAAGTTTGTCCACGCATCGGGGTTGTCCCGTCACATGGAAAAACATGCTCTAGATCTTATACCATCAACGTCATCGCATGCGAACAATGGCTATCCACCGATTAACGGCTTAAAAGTGGTTATTAAATGTACGATATGTGGTGGAATATTTTTTGAGGCCGAGACCGGATTTAAGCACATGTGTATGCATTTTCCCGAAACGGATGAAGCCGAACTGGACCTCGGGGACATTACCGAGTTTCCCTATGAGAACTACCTTGATGATGCTCTCAATTTTTTGAAGACTGAATCGAAAAATTCGAATAGCAAGCCCACCGCCTACCttaaaatggttattttaaGTTGTGTCTTGCAGTGCGAGTTTTGTGACTTTCTTTTCTCCGAggtttcgtttttgtttgccCATTCTGCATGCCATCAGCCACAACGACCGTTTGAATGTTATACATGTGAGATTTGTGTGTCAACTGCAAAGGAGATCTTTATGCACTGGCAGGCTGAGTGTGTGTTTGCGAGGGAGAATTTAAAACGTGGTTGTTCCGCACAAagatattatgtatgtaatgtGTGTGAAAATAAGTTTGGATCTCTGGAGCAGTTACATGCACACAGGTATACGGCTTACCACTTCTTTCCGAGGGTAGATCGAAGCAGAGAGACCCTGATGCTACCTTGCGAGTACTGTGATCAAGTGTTTGAAAATGCAAACGACATTGTGAATCACTTTGAAGAGCGACACTATAAGAAGAACAAACGGGATACCGGCGCAAAGTCCCGCCAATACTTGTGTGATATTTGTGGAAAGACGTACACACAATCGAGTCATTTGTGGCAGCACTTGCGTTTTCACAAAGGAGTCAAACCATTTGCCTGCAAGGTGCCAGGGTGCTCACGTCGATTTACCATCCGTCCCGATCTAAATGACCACATCCGCAAGTGTCACACCGGTGAACGTCCTTATCACTGCCTTATCTGTGGCAGACGCTTCCTAACTGGATCGGTGTTCTATCAACATCGCCTTATACATCGTGGTGAACGTCGATATGGATGCGACGAGTGTGGAAAACGATTCTACCGCGCCGATGCCCTAAAAAATCATCTCCGCATTCACACTGGCGAAAAGCCATACGGGTGCCTCTTTTGCACAAAAAGTTTCCGCCAGAGAGGGGATCGTGACAAGCACATCCGAGCAAGGCACTCCAGTTTAGATGCAAAGTCGCGTCTTATGATGCAAATGCGTAAGCTGCAATTAGAAGCGGCGGCTAAAGCTAGAGCCGACCCCTCATCATCGACACCAGCAGATGAGGTATTGATGTTCGGTAACATTGCATTTCCAAAGAGCATGTTTCAGCCGATGCTAGCGGATATCGACGCAGGCCAAGACTGA
Protein Sequence: MNCDDEYNNSEAWLAEQIFSQLKDFKTEPIKDDEENGKLTFDPLDSLNLDETNNVLDLSAPEVDEHINKEKEPQTKKDNDFAALDISQEQLHLPETDVDNQETQNLFQYLDPPFHVQQNIVECANCNCIFGADSFPEHICDYGEDKTLIIPEPMEPSMSSYHAGPVEPPCVRLLRENQIRIRRFLKDELKYDVNAGTTTTKKQDGPHECSLCERKFVHASGLSRHMEKHALDLIPSTSSHANNGYPPINGLKVVIKCTICGGIFFEAETGFKHMCMHFPETDEAELDLGDITEFPYENYLDDALNFLKTESKNSNSKPTAYLKMVILSCVLQCEFCDFLFSEVSFLFAHSACHQPQRPFECYTCEICVSTAKEIFMHWQAECVFARENLKRGCSAQRYYVCNVCENKFGSLEQLHAHRYTAYHFFPRVDRSRETLMLPCEYCDQVFENANDIVNHFEERHYKKNKRDTGAKSRQYLCDICGKTYTQSSHLWQHLRFHKGVKPFACKVPGCSRRFTIRPDLNDHIRKCHTGERPYHCLICGRRFLTGSVFYQHRLIHRGERRYGCDECGKRFYRADALKNHLRIHTGEKPYGCLFCTKSFRQRGDRDKHIRARHSSLDAKSRLMMQMRKLQLEAAAKARADPSSSTPADEVLMFGNIAFPKSMFQPMLADIDAGQD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00312121;
90% Identity: iTF_00316312;
80% Identity: -