Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00027 0.032 15.5 2.6 1 23 43 65 43 65 0.98

2 6 5.5e-06 0.00064 20.8 0.1 1 23 73 96 73 96 0.97

3 6 2.9 3.5e+02 2.8 1.1 11 23 139 151 127 151 0.82

4 6 0.5 59 5.2 0.5 1 9 158 166 158 168 0.92

5 6 4.8e-07 5.6e-05 24.1 0.3 1 23 172 194 172 194 0.98

6 6 0.018 2.1 9.7 1.1 1 13 200 212 200 217 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00027	0.032	15.5	2.6	1	23	43	65	43	65	0.98
2	6	5.5e-06	0.00064	20.8	0.1	1	23	73	96	73	96	0.97
3	6	2.9	3.5e+02	2.8	1.1	11	23	139	151	127	151	0.82
4	6	0.5	59	5.2	0.5	1	9	158	166	158	168	0.92
5	6	4.8e-07	5.6e-05	24.1	0.3	1	23	172	194	172	194	0.98
6	6	0.018	2.1	9.7	1.1	1	13	200	212	200	217	0.84

Coding Sequence: ATGGAAAACGGCAAAAGTTATACCTATTTTGAAGCCAGGTGTACAAAATTCAATCTCGGGAAAGTGTTTCCTGACAAGAAAGAAGCCCATATTATGATAACTCACGTTGATTTAAACTCCAGTGTGTTCCAATGCGAGTACTGTGAGAAGacgttcataaaaaaatatcggTACGATCAGCACGAGCTGACACATTTGCGTCCAGAAGAGAAGAAGTACATTTGCCATGATTGTGGGAAACCATATGCAACAGATGTTCTGTTGCGTGTTCATGTCCGAGTGGTTCATATGAAGTCTTACGCACAAAAGGTGCTAAAATCTTCGAGTCGAGTAATTTTCGAGAAACGCCAGCTGGAGCATATGGGACAAACGTTGCCACGGTGCAGTGCAAGCAAAATATGCAATGCGTGGATGAAGAACGAACACAAAATGCGAGCGCACATGCGGTTGCATGATGATGAGGGTACAGTGCACAAATGCGAATTGTGTGGAAAGACCGGACCTGAGCGTATATTTGAATGCACCTTGTGTGAAAAGGCTTTCAAGAGAGCGGTATCACTAAAGGAACACATGATGCTGCACACAGGAGAAGTATTGTACAAATGCACACTTTGTACGAAAACATTTAATTCCGGAGCCAATATGTGCATATTCCAAGCACTAAACCAAGTTGAGCCTCGCACAATTCTAAAACTGTGTATATAA
Protein Sequence: MENGKSYTYFEARCTKFNLGKVFPDKKEAHIMITHVDLNSSVFQCEYCEKTFIKKYRYDQHELTHLRPEEKKYICHDCGKPYATDVLLRVHVRVVHMKSYAQKVLKSSSRVIFEKRQLEHMGQTLPRCSASKICNAWMKNEHKMRAHMRLHDDEGTVHKCELCGKTGPERIFECTLCEKAFKRAVSLKEHMMLHTGEVLYKCTLCTKTFNSGANMCIFQALNQVEPRTILKLCI

Sequence clustering based on sequence similarity using MMseqs2