Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00039 0.046 14.9 0.2 1 21 118 138 118 139 0.96

2 6 2.5e-06 0.00029 21.9 1.0 2 23 153 174 153 174 0.98

3 6 0.001 0.12 13.6 0.9 2 23 181 202 180 202 0.98

4 6 0.48 57 5.2 1.1 1 11 232 242 232 244 0.94

5 6 0.0041 0.49 11.7 0.1 1 20 254 273 254 275 0.94

6 6 0.00019 0.022 16.0 0.7 1 20 282 301 282 301 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00039	0.046	14.9	0.2	1	21	118	138	118	139	0.96
2	6	2.5e-06	0.00029	21.9	1.0	2	23	153	174	153	174	0.98
3	6	0.001	0.12	13.6	0.9	2	23	181	202	180	202	0.98
4	6	0.48	57	5.2	1.1	1	11	232	242	232	244	0.94
5	6	0.0041	0.49	11.7	0.1	1	20	254	273	254	275	0.94
6	6	0.00019	0.022	16.0	0.7	1	20	282	301	282	301	0.97

Coding Sequence: ATGAATATCGTTAAGCAAGAAAAATTCACTGTTGAGGAAGATGTTGTTCCCGTCGTTTTGCATCCGGGCACCTACAGCACTTATACAATACACACATTTCAAGCGACCGATGAGGATGCCGCTGCAGTGGCAACGCTGGAAGGGAATCAAATGCATCAAATTAGACGTACAATTAATGGTGAGGGTGTTATTGGACAACAAATAATTCAACTGAACGATGGCGATTGTGTAGAAATTCAGGATGTTGCTGCTACGTCGACTCCAGAAGAAGTAGCACATTCAGAAGTTTCCTATCATAGTGACAATTCGGCCGAGTATGGCATGGTACCGGAGACAACTAAGGCAAAGACATTCTACTGTCCAAACTGTGGAAACTGTTACAGTGCAGCTGGAAGTTTAAAGTTGCACATTCGAGCTTGCACCCGTGAGAAGGAGACTCCTTCTAGTGAAGGACGAAAATGCGAGATTTGTCAGCGAGTTTTCAACTCAAGTACATACTTAAGGGAACACATGCTGCGACATACCGGCAAAGGACCCAAGAAATGTCCAAAGTGTTACCGCAAATTTATTGACGACACCAAGTACGAAGCACACTTGGAGACACACAAATTGGAGGAAAGAATTGCCAAGGAAGCCGGCGCTGCGATCAACTCTGAAGCAGGGTGCAGTGGGGAGAAGAAGATTGTTAAAGAATATACGTGCTCGTTCTGTTCGAAGAATTTCACTGTTATATTCGATTCACGTCATACCAAGCGGCGGTATGCTTGTGACGAATGCCGAGAGAAATATTCCAATGAGGAGCTGCTGAAGGAGCATAAGGCCCAGCTGGAAGAAAAGCGTGAGTTCCGTTGCGAAAAATGTGGGAGGAAGTTTGTTTTCGAAGGATTTTTGCAGAGGCACTTACCCTCTTGTGATGGTACGATTCGCCGCCGACGTGACCGTCAATAA
Protein Sequence: MNIVKQEKFTVEEDVVPVVLHPGTYSTYTIHTFQATDEDAAAVATLEGNQMHQIRRTINGEGVIGQQIIQLNDGDCVEIQDVAATSTPEEVAHSEVSYHSDNSAEYGMVPETTKAKTFYCPNCGNCYSAAGSLKLHIRACTREKETPSSEGRKCEICQRVFNSSTYLREHMLRHTGKGPKKCPKCYRKFIDDTKYEAHLETHKLEERIAKEAGAAINSEAGCSGEKKIVKEYTCSFCSKNFTVIFDSRHTKRRYACDECREKYSNEELLKEHKAQLEEKREFRCEKCGRKFVFEGFLQRHLPSCDGTIRRRRDRQ

Sequence clustering based on sequence similarity using MMseqs2