Cpag004526.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cheilosia pagana
Gene Symbol
run
Assembly
GCA_936435595.1
Location
CAKZFE010000013.1:5212747-5255780[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 8.4e-71 4.5e-67 223.8 0.0 4 129 39 164 36 164 0.98

Sequence Information

Coding Sequence
ATGATGGTGGTCGCGCTGGTCGAGGGTAACAACAACAGTGCGGCAAATAAGAAAACTGTAGACAACAGTCCGTATTTGACACCGGAAAATCTGATAGAAAGAACTGTTGATGGACTGCTGGCAGAACATCCGGGAGAGTTGATGAAGACCGGATCGCCTCATGTTgtctGCACAGTGCTGCCAACTCACTGGCGCTCCAATAAAACTCTACCGATTGCCTTCAAAGTTCTAGCGCTGGGCGATGTCATGGATGGAACAATAGTGACTATACGCGCTGGAAACGACGAGAACTTCTGTGGTGAACTACGCAACTGTACGGCCGTGATGAAGAATCAAGTAGCCAAATTTAACGATCTACGGTTTGTGGGGAGAAGTGGAAGAgGGAAAAGCTTTAGCCTAACCATCGTGATATCATCCACCCCCATCCAAGTGGCCTCCTACAATAAAGCCATCAAGGTAACCGTAGACGGTCCCCGGGAGCCAAGGTCAAAGGTGCGCCATCAGGGATTCCATCCATTTGCATTTGGCCCGCAGCGTTTCGGTCCGGATCCACTTATGGGCGGCTTACCGTTCAAATTGCCAGGTTTCGCGCACCACTTAGCCGGTATGCATGGCCACCTGCACGCGCCCGACTGGCGTTCGCTGGGCGCGAACCCAGCACTCGGTCGGCCTGGTTTTCCTCACGGTGCCTCTTTCTTTCACCACCAACATGCCGCATTTCCTCCCCACGCACTGGCGAATACACTCGAACGTCTAGACCGCCCGGGACTACGAGCAATTAgtgATAATCACCACATAGCGCAACTTAATCAATTATCAGCTTCCTGCAATCCACACAGCACGACCAGCCCCGAAGGATCACCGACAACGGCCACCCTGCATAATAGAAACTCCGCCTCCTCCCCACTGACAAGTgaaaacgacaacaacaacaacatcgatGCGGGCTTTGAAAGTGACAGCATATCTGTGACAGGATCGCCACGAAAGAGTAGCTCAATACACGAGGACGACGACCGAAGAACTCCATCACCCCAGACGGGCGCGTTCACTGCACTCATCCAAAGAAATCCTACGCTGAGAAAAAATGAAATCTTCTCCGGCTTCGCGTCACACTTCCAACAGCCGAATGTCTTCAATCCCGCCCTAGCGGCTCAACTATTTCTGCAGAATCCCCTAATTCCACAGCCCAGTCAGTGGCTATACACTCAGTTGTATGGCAACTATCACGACATGCCGTGGTTCCGGAATGGCACCTCGACCAGCAGCACAAACAGCAACGCCACATCGAATGGCAGCCTGCAGGATGCAGTGGCTGGGGTTAACCTAGTCAAGCGTTGTGTCACTCTAATCACACACTCCAATGATGACAAGGACAGTGAGAACGCGAATCCGAATGCTTCACCGCCAGTTTCATCGACACGAAGATCACCATCACCCGACGATATCGTCGACGataggagcagcagcagcataggACCTATGCGTTGTAGGACACCCAAGCACACAGACGTCTGGCGGCCGTACTAG
Protein Sequence
MMVVALVEGNNNSAANKKTVDNSPYLTPENLIERTVDGLLAEHPGELMKTGSPHVVCTVLPTHWRSNKTLPIAFKVLALGDVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFSLTIVISSTPIQVASYNKAIKVTVDGPREPRSKVRHQGFHPFAFGPQRFGPDPLMGGLPFKLPGFAHHLAGMHGHLHAPDWRSLGANPALGRPGFPHGASFFHHQHAAFPPHALANTLERLDRPGLRAISDNHHIAQLNQLSASCNPHSTTSPEGSPTTATLHNRNSASSPLTSENDNNNNIDAGFESDSISVTGSPRKSSSIHEDDDRRTPSPQTGAFTALIQRNPTLRKNEIFSGFASHFQQPNVFNPALAAQLFLQNPLIPQPSQWLYTQLYGNYHDMPWFRNGTSTSSTNSNATSNGSLQDAVAGVNLVKRCVTLITHSNDDKDSENANPNASPPVSSTRRSPSPDDIVDDRSSSSIGPMRCRTPKHTDVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01300589;
90% Identity
iTF_00187821; iTF_01300589; iTF_01541207; iTF_01541937; iTF_00688380; iTF_01116224; iTF_00389395;
80% Identity
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