Basic Information

Insect: Chalcosyrphus nemorum
Gene Symbol: lz
Assembly: GCA_949716465.1
Location: OX454332.1:20269821-20282030[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.2e-17 3.8e-14 52.5 0.1 93 129 49 85 45 85 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.2e-17	3.8e-14	52.5	0.1	93	129	49	85	45	85	0.96

Sequence Information

Coding Sequence: ATGACTCACAagacgagccacttgctgcaagCCTCTGTTACGttagaaaattcaattcagaaACTGGCAGCGCTGGAGGAGCATCATTTTGGTTTTACCACACCACATCCTGTGACTTTGTTTAAGGACTTTTCACAAGATCCCGGGAAAAGCTTTACATTAACCATCACCGTATCGACATCACCACCGCATATAGCCACCTACAATAAGGCGATAAAAGTCACTGTGGACGGACCCCGGGAGCCCCGCTCGAAGACAAGACAGCAACAACAGTTCCACTTTGCCTTTGGCCAGCGACCGTTTCATTTCTCTGCGGACCCTCTGTCAGGATTTCGTATGCCGCCCATTGGAAATTGTCAAAATATGTCACAATTTGGATTGGGAGCAGCCAATACCCACTGGGGATATGGATCAGCAAGTGCATACTCACCGTATCTGGCTAGCAGTGGACTCTCATCCTGTACGACTCCATCGTCTGCGCAATTTAATAATCCAGCGCTGGGTTTCACCTGCTCGTCTAATGATCAAGCCAATAATCAGGACTTTTCTGGAGCGGCGAATCGTGATTGTGTTCCAATGCTTCCTGATTCAACAGCCACTGACTTGGATCAGCATCTGAGCAACCTTGTCGGCTCAACCACCGGTCAAATGACACACCACAGCCTGTTGGGCGGCACAGGCCAAACATCGATTTCCTCGACTGTGAATGGTGGTGGATCGGCCAATACCGCCATTTTAGTGCCGCGTTATCATTCTAACTCAAATCAGGAATACAACGTCCATTCAAGTCAGAACGGTCCACGAAGTCTGAGTGATTCCTCGCAAGCCGAATCGCCTGTCCAAGAAGACCTACTCACGTCGAACACACCAAATCTGGGTGGCGGTGGAGCAACTGCTGGCAATGCCGGCAATGGGACGGGAACCAACAATGCCGTGGCTGCTAATCAGAACTTCACCGGAATAGTCAACCAAACACAGAACACAGCGGCAGCGTACAGCTCCACCGGTGGCAGTGGGTGTAATGGTTCACTATATCCTGTTCTTCCTGCCAGTCTTCTGTACTCTCAACTCTATACGGCTGCGAATCAAACGCATGGCTTCCATTCACATTCTCTGCCACCGCATGCCTCACCGAACTCGGCGGTGCACGGTGAACTGCAAAGTGTCATGGATCACATCAGTAATGTTGGTGCTCGTCAACAGCATCACATCATGGCTGGCGGGGGTGGTAATACCCACCCAGGTGATCTGACTCTAGTTGGCAACTGTGGCGCTTCAGCACGAAATGTCGACGATGGCAATACCAACCGACAGGTGGCGCTAGCCGCCCACCGTGGTCACCACAATCCAACTGACAATGGGAACTCCGTCTGGCGGCCATATTGA
Protein Sequence: MTHKTSHLLQASVTLENSIQKLAALEEHHFGFTTPHPVTLFKDFSQDPGKSFTLTITVSTSPPHIATYNKAIKVTVDGPREPRSKTRQQQQFHFAFGQRPFHFSADPLSGFRMPPIGNCQNMSQFGLGAANTHWGYGSASAYSPYLASSGLSSCTTPSSAQFNNPALGFTCSSNDQANNQDFSGAANRDCVPMLPDSTATDLDQHLSNLVGSTTGQMTHHSLLGGTGQTSISSTVNGGGSANTAILVPRYHSNSNQEYNVHSSQNGPRSLSDSSQAESPVQEDLLTSNTPNLGGGGATAGNAGNGTGTNNAVAANQNFTGIVNQTQNTAAAYSSTGGSGCNGSLYPVLPASLLYSQLYTAANQTHGFHSHSLPPHASPNSAVHGELQSVMDHISNVGARQQHHIMAGGGGNTHPGDLTLVGNCGASARNVDDGNTNRQVALAAHRGHHNPTDNGNSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00310786; iTF_01044515; iTF_00984004; iTF_00717510; iTF_01256183; iTF_00893638; iTF_00663824; iTF_00974412; iTF_01396264; iTF_00426128; iTF_00334745; iTF_01318000; iTF_00389397; iTF_01521655; iTF_00240440; iTF_01223165;
90% Identity: iTF_01044515;
80% Identity: -