Basic Information

Gene Symbol
ZNF217
Assembly
GCA_949987625.1
Location
OX465097.1:6241585-6255984[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.0066 1.2 10.9 0.2 1 23 178 201 178 201 0.97
2 16 5.5e-07 0.0001 23.8 0.5 1 23 215 237 215 237 0.99
3 16 0.0032 0.59 12.0 5.2 1 23 261 283 261 283 0.99
4 16 0.00097 0.18 13.6 0.1 2 19 290 307 289 307 0.97
5 16 0.0018 0.33 12.7 0.1 1 23 318 340 318 340 0.97
6 16 0.0001 0.019 16.7 0.2 1 23 346 368 346 368 0.98
7 16 9.8e-05 0.018 16.7 1.0 1 23 374 396 374 396 0.96
8 16 0.00025 0.046 15.4 0.0 1 23 402 424 402 424 0.97
9 16 4.6e-05 0.0085 17.7 2.6 1 23 430 452 430 453 0.93
10 16 0.00041 0.076 14.8 3.8 2 23 579 600 578 600 0.97
11 16 0.0058 1.1 11.1 3.6 1 23 606 629 606 629 0.96
12 16 0.00011 0.021 16.5 2.0 1 23 635 657 635 657 0.96
13 16 4.9e-06 0.00091 20.8 0.5 1 23 663 685 663 685 0.97
14 16 0.065 12 7.8 2.9 1 23 691 713 691 713 0.96
15 16 2.3e-06 0.00043 21.8 1.0 1 23 719 741 719 741 0.97
16 16 4.2e-05 0.0079 17.9 2.5 1 23 747 770 747 770 0.98

Sequence Information

Coding Sequence
ATGTGCATTCGCGCAGGTGTACCTTATGTCTTTCTCGATGTGAAAAGTCTTGCATTAAGCACATACGTACACGAGCTCAGACAAAAGTTTACTTGGAAAAAGCTCAAAGCTCGAGGATCGCCTACGTACgtatatgaaaatgaaaaaacgcGCGAAGACACACGTGATGCAGGCCAGGAGAGGAGCAGCGACTCGGCGAACAATATCGAGGaacTTTTGCATCCAAAGCTACAAGAGATGATCACCTCCGAATTCACACAGGTGAAAGACCTTATGTTTGCCATACTTGTGGAAAATGCTTCAAGTCAAAAGCATCACTTTATACGCATGTTAAAACTCACACCGATGACTTTCCTCACCCTTGTCTGCATTGTGAAAAAAGATTTCGTAGAAGACAGGAACTTCTTAGTCACGTTTCCATGCATACTGGCGAAAAGAATTTCGAATGCGACACATGCTTTAGAAGATTTAGAATCTGCTGTGGCATCGACGAGCAATAAAACGCAAGAAACATCGAACCAaaaatacatgtacatgtgCGGGCTCTGCGACGAATTCTATAACGAGGAACTCGAGCTCATTCGCCATTTGAAAAAGGATCACGATGCAGCGGAGTCCTTTAAATCCATAAATCCCGTCCGTTACGAGTGCAACGTTTGCAGAAAGTCCTACGTGCagaagataaatttaataagccaCATGCGGATACACAAGAAGGAGATGCCGGGCGAGGCGGGCATCGTCGAGAAGTCCAAGATCTTTCACAACAAGGTGCGCATGTACAAGTGCGACAAATGCGGCCATCTCCTCTCCCATCGGCGCACCTTCTTGCGGCACATCCGCGTCCACGCGAACGAGCGCCCGATCACTTGCCAAGAGTGCGGCAAGGGCTTTAGAATCGAGGACGATCTGAAGCGCCACGACGACGACGTCCACAAGAAGATAAAGCGTTTCGCGTGCGACATTTGCGGCACGGCGTTCGCCGCTAAGTCGACCCGCGACGCCCATCGACGCATCCACACCGGCGAGAAGCCCTTCCCGTGCGGCATCTGCAACAAGACCTTCCGCTCGATAAATCTCTTGGGTGTTCACAAGCGCGTCCACACGGATTACCGGCCGCACAAGTGCGCTTACTGCGAGAAAGCGTTCAGGGACAAGCAGAAGCTCGCCGCCCACGAGACCATTCACACCGGTATAAGGCCTTATCCCTGCGACGTCTGCGGGAAAGCGTTCTCGGCCAAGGGCGAGGCCTCGAGACACCGCACCGTACACTTCGAGCACAAGCCCTTCCTCTGCTCCGAGTGCGGTTTGAGCTTTCGATTGAACAGATATCTTCTCTCTCACATGAAGACCCATCATCCGGAAGAATCGAAAAATCCACAGCGTACTTGCGTCAGCTTCAAAGAATTTCAGAAAACATATAAACCTACCATCGAGTCCATAAAAAGTCGAAAAAAGCCTCAAGCTGCAAGTAAACCCTTGAGGAAGAGAACGAGGCGTACGATTAAAAAAAGTCCCGGAAAAGCCTCTCTAAAAGACGTAAAATTGGAAGTGGAAAGTCATAACGTTATTCCCAAGCAAGAAACGGAAGAATTAATAATACCGGATTTCAAAGTGGAATCAATCTCCGTGGACAACGACACCGAGAGCGAAGATTTCATCGAAAGCTTGCCATCGCCGGCCGAGAGCATAAAAGTGAAGAAGCCGCGAAAAAGGCACGCCACCGAGGCCCTCCAATGTAATCTGTGCAACAAAAAATTTCGTTTGCACAACAGTTATCAGATACACATGAGATTGCACACCGGCGAAAAGCCTTACGCCTGTCACACCTGCGACAAACAATTCGGCCAAACCGGCAGCCTCTATTACCATCTCAAACACGTACACGGCGGTGTTAAAAATCACGCCTGCGACATATGCGGACGTTGTTTCGCTATGAAAACGGCAATGCAGGATCACCGTAGGATACACACCGGCGAAAGGCCGTACGTATGCGACTCGTGCGGAAAAACTTTCAAAACCAAGGCGTCGCTTTACATTCACGGCAAAATCCACACGAACGACTATCCGTTCAAGTGCTcgtattgcaaaaaattatttcgatggAAGCAGCAAATGATCAGCCACGAGACGACTCatactggtgaaaaaaatcACATTTGCGACATTTGCGGCAAGGGTTTCGGCGTTAAAAACGAGCTTACCAGACACAGGCGCACACATTCCTCCGACAAGCCGTTCACTTGCCAAAAATGCGGTGTCAGCTTCGGTCAAAAGAGATACCTGACTAATCACAATCGAACGCGGCACAAGGCCAAAGCGACTGGAAATTCGTAG
Protein Sequence
MCIRAGVPYVFLDVKSLALSTYVHELRQKFTWKKLKARGSPTYVYENEKTREDTRDAGQERSSDSANNIEELLHPKLQEMITSEFTQVKDLMFAILVENASSQKHHFIRMLKLTPMTFLTLVCIVKKDFVEDRNFLVTFPCILAKRISNATHALEDLESAVASTSNKTQETSNQKYMYMCGLCDEFYNEELELIRHLKKDHDAAESFKSINPVRYECNVCRKSYVQKINLISHMRIHKKEMPGEAGIVEKSKIFHNKVRMYKCDKCGHLLSHRRTFLRHIRVHANERPITCQECGKGFRIEDDLKRHDDDVHKKIKRFACDICGTAFAAKSTRDAHRRIHTGEKPFPCGICNKTFRSINLLGVHKRVHTDYRPHKCAYCEKAFRDKQKLAAHETIHTGIRPYPCDVCGKAFSAKGEASRHRTVHFEHKPFLCSECGLSFRLNRYLLSHMKTHHPEESKNPQRTCVSFKEFQKTYKPTIESIKSRKKPQAASKPLRKRTRRTIKKSPGKASLKDVKLEVESHNVIPKQETEELIIPDFKVESISVDNDTESEDFIESLPSPAESIKVKKPRKRHATEALQCNLCNKKFRLHNSYQIHMRLHTGEKPYACHTCDKQFGQTGSLYYHLKHVHGGVKNHACDICGRCFAMKTAMQDHRRIHTGERPYVCDSCGKTFKTKASLYIHGKIHTNDYPFKCSYCKKLFRWKQQMISHETTHTGEKNHICDICGKGFGVKNELTRHRRTHSSDKPFTCQKCGVSFGQKRYLTNHNRTRHKAKATGNS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-