Basic Information

Gene Symbol
ZEB2
Assembly
GCA_949128085.1
Location
OX421885.1:42730223-42731668[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.071 13 8.1 0.1 2 20 132 150 131 152 0.86
2 11 2.9e-07 5.3e-05 25.0 2.0 1 23 177 199 177 199 0.98
3 11 0.14 25 7.1 6.6 1 23 205 227 205 227 0.96
4 11 0.0004 0.074 15.1 1.1 1 23 233 255 233 255 0.96
5 11 0.00066 0.12 14.4 1.7 1 23 260 283 260 283 0.95
6 11 0.00049 0.09 14.8 3.1 1 23 287 309 287 309 0.97
7 11 3.1e-07 5.6e-05 24.9 0.2 1 23 315 338 315 338 0.98
8 11 5.2e-06 0.00095 21.1 0.2 1 23 344 366 344 366 0.98
9 11 4.1e-06 0.00075 21.4 0.6 1 23 373 397 373 397 0.96
10 11 3.8e-07 6.9e-05 24.6 0.9 1 23 403 425 403 425 0.99
11 11 3.5e-06 0.00065 21.6 3.4 1 23 431 453 431 453 0.98

Sequence Information

Coding Sequence
atgTCCGAAATTTGCAGATTGTGTCTAAATGATGCAGCAAAGCCTGTCGATGAAGAAATATCTGACAATACTGCTGCATATAGAACACAAATAGAATTATTAATGCCAGAAATCGACCTGAATATAACGGCAGCATTTGCTTTATGCAGTCAGTGTTCCTTTAATTTAAACTCTGCTTATAAGTTTAAAAGCGAATGTTTGCGCATCGAACAACTCATAAATGATTACCGAAAAGAATTAAATGCGCCCCTTATCGATTTAAGGGAAATTAAGAATCAACAATTATCAGATGATGGTGACGAACTTATATCTGTGAGTAAAGTTAAAATTGAAGAGTGTGATGAGAGTGTTGATTTACAAAGCATAAATACGGGGATTACGGGTGTTAGCCTTATTTGTGACAAATGTGATGAGGTTTTtaacaatgaaaatatatttcaacaGCATATAGAAAGTTGTGACAGTAATATTGAATGTAAGACTGAATCCCGATTTGAAGATGAGTCTGTTGGGGAGAATTTAGATACTTTCATATGCAAATATTGTCGTCGGTCGTTCACAACATCTGCAGCTTTAAAAAGTCATTTGAGAACACATTTAAAACGACCTCAACATATGTGTGATACATGTTGCAAAGTGTTTAAGACGAAACGTCAGTATGAGGAACACCTTTTTTCGCATACAGGTAAAAAGAGGTATTTTTGTAAAGTATGCAATAAAGGCTATAATCGAATGTATACACTGCAAACGCATGAGGAGATACACAAGAATAAAAAATTCGACTGCTCAATGTGTATAAAATCGTTCCCCAGCAGACGATATTTAAAACGCCATCAATTGAATTCCCATCTTGGAACTCACATTTGTAAAACGTGTGGTATAAAATGTGGCACCAGCTACGCCTTGAAGGAACATTTACGGTCACATACCGGCGACCGGCCCTATAAATGCGAAGTTTGCGGGAAAGGCTTTGCGCAAAGTGGAACACTGAGTGTGCACATTAGATCCAGGCATATAAAGGAGAAGCCGTTTGTTTGTGAAATATGTGGTAAGGCGTTTGCATTCAAAGCGAGTTTAAAGGGGCATACGACAACCCATATGGATATCCCCAAGAATTTTACTTGCTATGTTGATGGTTGTAATAAGACTTTTCGCACTGCCCCGAATCTGCGCGATCATGTTCGACGTCATAATCTTCCAAAGGATTTTAAGTGCTCCATTTGTGAGAAAGGATTTAAAGACATAACAGCTTTGCGGAGGCATCTACGAACGCATACTGGGGAGAAGCCGTATGAATGTGGCATTTGCCATAAAACTTTTagcgaaaaatataatttagaaacGCATTTTAAATCACACAGatctaagaaaaataaaatggctaATGGATAA
Protein Sequence
MSEICRLCLNDAAKPVDEEISDNTAAYRTQIELLMPEIDLNITAAFALCSQCSFNLNSAYKFKSECLRIEQLINDYRKELNAPLIDLREIKNQQLSDDGDELISVSKVKIEECDESVDLQSINTGITGVSLICDKCDEVFNNENIFQQHIESCDSNIECKTESRFEDESVGENLDTFICKYCRRSFTTSAALKSHLRTHLKRPQHMCDTCCKVFKTKRQYEEHLFSHTGKKRYFCKVCNKGYNRMYTLQTHEEIHKNKKFDCSMCIKSFPSRRYLKRHQLNSHLGTHICKTCGIKCGTSYALKEHLRSHTGDRPYKCEVCGKGFAQSGTLSVHIRSRHIKEKPFVCEICGKAFAFKASLKGHTTTHMDIPKNFTCYVDGCNKTFRTAPNLRDHVRRHNLPKDFKCSICEKGFKDITALRRHLRTHTGEKPYECGICHKTFSEKYNLETHFKSHRSKKNKMANG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
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80% Identity
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