Basic Information

Gene Symbol
-
Assembly
GCA_949128085.1
Location
OX421884.1:9259235-9266708[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.014 2.5 10.3 1.9 1 23 160 182 160 182 0.98
2 16 0.00049 0.089 14.9 7.2 1 23 187 209 187 209 0.97
3 16 0.00014 0.026 16.5 5.3 2 23 216 237 215 237 0.96
4 16 6.5e-05 0.012 17.6 0.1 1 20 243 262 243 264 0.94
5 16 1.6e-06 0.0003 22.6 0.5 1 23 271 293 271 293 0.98
6 16 5e-05 0.0092 18.0 1.5 1 23 476 498 476 499 0.94
7 16 0.00034 0.062 15.4 4.2 1 23 505 527 505 527 0.97
8 16 9.8e-05 0.018 17.0 5.7 1 23 533 555 533 555 0.98
9 16 0.013 2.4 10.3 2.0 1 23 561 584 561 584 0.94
10 16 0.012 2.2 10.5 1.8 1 23 596 618 596 618 0.97
11 16 1.7e-05 0.0031 19.5 6.7 1 23 624 646 624 646 0.97
12 16 2e-06 0.00036 22.4 0.5 1 23 653 675 653 675 0.96
13 16 1.2e-05 0.0022 19.9 1.3 1 23 681 703 681 703 0.98
14 16 1.3e-06 0.00023 23.0 0.5 3 23 711 731 709 731 0.96
15 16 2.5e-05 0.0046 18.9 0.2 1 23 737 759 737 759 0.99
16 16 0.018 3.3 9.9 0.2 1 23 764 787 764 787 0.96

Sequence Information

Coding Sequence
ATGGAGTGCGTACGGATAGATTTAAACAATGCATGCAGGACTTGTAAATGCGAGTCGCCGGAAATGAAATCTCTGTATTACAGAGACTCGGAAAGTGGTAAGGAAAATCCCCGTTTGGACGAGATGCTAATGGCATGTGCGTCTGTACAGGTTAGTAATGACGACGGCTTGCCGAAATTAATATGTCGGTCTTGTTACGTTCTGTTAAAAAATGCGTACGCCTTCAAAGAGCAGTGCGAAAAGACGGAGGTATTCTTCAAGGAGTATTTGAAGAAGGCGAACGTAAAAGAGGAAACCCTTCCGGGCGACTTGGAGTATTTGGCAAATGTGACAGATGACATTAGCTCGGAGCAAGCTGATGTAGAGGAGAATAGGAATGAATCTGAAGAGATTAAGGATGATCCCGAAGTTCATACagatcaagttgttgaaaagaGTATGGACTATGTGCAGgtatttgacgaaaatattgcaatttatcgGTGTAGAATATGCTCCAAAGATTTTTATACGCTAGAGGGTTTAAAGTTCCACAAAAGAGTACACTCTGGTAGGACTTTCAGTTGCAAACAATGTAATAAATCCTATACAAGATTGCACCATCTCTACAGACACGAATTATCTCATACAAGGAGTAAAGTCTGCGTGTGCAAACTATGTAATAAGACGCTAACGAGATTAGATcatttaaagaaacatttaatAACACACCTGAAAGAGAAACCTTTCGTTTGCTCAAAATGCGGTAGAGGATTTAATCGTACTGCGAATCTCGAAAACCACGTTGCACGGTGTAAAGGAGAGCAGGTTTATATTTGTGATATTTGCAATAAAGCTTTCAATCGACAAGACAGCATGGAGGTGCACAGGAAGACACATCAGAATAAGATTCCTGTGTTACCCACATTGGAAAGTATTGATAATGTCTCGGAATATTACATGGAGATCGATTATAATGAAAAAACTGTGTTTATCGATGAATCTGAAGCAGAAGAAGAGGAAGGGGAGGAGGAAGAAGATGAAGATTTTGATGTTACAGAGGAGACTGTGGAACCGGAAGTCGAAGTTTCAGAAAATCACGATCAAGTGAAGATAGATGAGATAGCTGAGATAACTAAAGAAATTTATGCGGAGGAGGATCCACCCGAGATGATGCTGGCGCAAGCGAAAATTAAAGAAGAGATTTACAGAGAAAGCAGAAATGCCGATGTTGAGGCTGATAACGGCAACCCTTGTAATTCTGATGATAGCAAACACTCTGAGTATTTACCTATGAAACCTTTACCGAAAATAAAAAGAGGTAGAGGAAGACCACGTAAACATCCGGTATCGTATAAACCTTCCGGAAGACCTAGAGGGCGCCCTCCATCTAAGCATAAAGTCAAGCCAGAACCCAAACCAATATCCGAAGAAGAAACTGGTCATTTTAAATGCCCACAGTGCAATATAGTATTTACGACCCTCTTCACGTTAGAAAGACATGCCGAGCAGCATCACGACGGTTTAAAATTGCATGAATGCGAAACATGCAAGAAGAAGTATAGCAGATTAAATAGCCTTAAACGCCATAAATTAGTGCATTTGGAAACGAAGCCGTTTGTATGCGGGACTTGTCTGAAGTGTTTCTCGAGGCGGGATCACATGCTGAAGCACATGAGGCTGCATAACAGCTCGAACGCGCACACTTGCAACGTATGCCAGGCAGTTTTCAGCTGCCCTGAGAATTTGATGAGGCACGAGGCGCGCAAGCACGGTGCGGGAGAAAAAATCGTTGTCGATAAGAAGTACGAGTGCGACTATTGCATGAAAACCTTTACCACGGAGAGGTATAGAGATTCACATATGAAAGCGCATCTAGGAGAGAAAAGACATCAGTGTAAGACATGCGAGAAGACATTCATTTCGAAATCGCATTTAAACGAACATATGAAATTCCACAACGATAGTTCAAAGAACTTTTTGTGTTCGGAATGCGGGCAGAGATTTATTCGGAACGATTATTTGGTTATTCACATGAGGAGGCATCGAGGAGAGAAACCGTTCAAGTGTAAATTCTGCGGGAAGGGCTTTCCACGGACAACAGACTTGACTGTACACGAGAGGTATCACACGGGGGAGAAGACCCATTTGTGTGTCATTTGTGGAAGAGGGTTCGGGAGAGCCTACAATTTAACAGTTCACATGAGAACGCATACAGGGGAGAAACCATACCGTTGCACATATTGCGATGCTGCTTTTGCTCAGGGTAACGATTTGAAAGCTCATGTTCGAAGGCACACGGGGGAGAGGTTTCAATGTGATATATGCCCAGAAACATTTTTGATGGGATATTTATTAACTCAACACAAACGGGTTGTGCATGGTTTAAATATCGTTAGTAACATAAGGCGGTTGCAACCAACTAATAAAATCAATCCTGATGACCCTCCACCAATCACCGTACCTTTACCTGCACCAGTTATCGTATCAGCGGCTATAATGGTTGATCCATTAGAGATCAGCAAGACGGAGATAGCGCCGGAGGAACTAAAGCAGGAATAA
Protein Sequence
MECVRIDLNNACRTCKCESPEMKSLYYRDSESGKENPRLDEMLMACASVQVSNDDGLPKLICRSCYVLLKNAYAFKEQCEKTEVFFKEYLKKANVKEETLPGDLEYLANVTDDISSEQADVEENRNESEEIKDDPEVHTDQVVEKSMDYVQVFDENIAIYRCRICSKDFYTLEGLKFHKRVHSGRTFSCKQCNKSYTRLHHLYRHELSHTRSKVCVCKLCNKTLTRLDHLKKHLITHLKEKPFVCSKCGRGFNRTANLENHVARCKGEQVYICDICNKAFNRQDSMEVHRKTHQNKIPVLPTLESIDNVSEYYMEIDYNEKTVFIDESEAEEEEGEEEEDEDFDVTEETVEPEVEVSENHDQVKIDEIAEITKEIYAEEDPPEMMLAQAKIKEEIYRESRNADVEADNGNPCNSDDSKHSEYLPMKPLPKIKRGRGRPRKHPVSYKPSGRPRGRPPSKHKVKPEPKPISEEETGHFKCPQCNIVFTTLFTLERHAEQHHDGLKLHECETCKKKYSRLNSLKRHKLVHLETKPFVCGTCLKCFSRRDHMLKHMRLHNSSNAHTCNVCQAVFSCPENLMRHEARKHGAGEKIVVDKKYECDYCMKTFTTERYRDSHMKAHLGEKRHQCKTCEKTFISKSHLNEHMKFHNDSSKNFLCSECGQRFIRNDYLVIHMRRHRGEKPFKCKFCGKGFPRTTDLTVHERYHTGEKTHLCVICGRGFGRAYNLTVHMRTHTGEKPYRCTYCDAAFAQGNDLKAHVRRHTGERFQCDICPETFLMGYLLTQHKRVVHGLNIVSNIRRLQPTNKINPDDPPPITVPLPAPVIVSAAIMVDPLEISKTEIAPEELKQE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-