Basic Information

Gene Symbol
ZNF236
Assembly
GCA_949128085.1
Location
OX421887.1:42372158-42379272[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 23 0.00048 0.088 14.9 1.0 2 23 10 31 10 31 0.98
2 23 0.0067 1.2 11.3 0.2 1 23 37 59 37 59 0.98
3 23 0.0058 1.1 11.5 0.7 1 23 72 94 72 94 0.96
4 23 3.3e-05 0.0061 18.5 4.6 1 23 119 141 119 141 0.98
5 23 1.6e-06 0.00029 22.7 0.2 1 23 147 169 147 169 0.97
6 23 0.0012 0.22 13.7 0.4 1 23 175 198 175 198 0.96
7 23 0.0028 0.5 12.5 1.8 1 23 208 231 208 231 0.97
8 23 1.2e-06 0.00022 23.0 0.5 1 23 311 333 311 333 0.98
9 23 4e-05 0.0073 18.3 1.3 1 23 339 361 339 361 0.99
10 23 0.00037 0.068 15.2 2.1 1 23 367 389 367 389 0.99
11 23 0.0035 0.64 12.2 0.8 1 23 400 422 400 422 0.98
12 23 1.6e-05 0.0029 19.5 4.6 1 23 478 500 478 500 0.99
13 23 1.2e-05 0.0022 19.9 1.6 1 23 506 528 506 528 0.98
14 23 0.00075 0.14 14.3 0.2 1 23 534 556 534 556 0.97
15 23 0.00068 0.12 14.4 2.6 1 23 562 584 562 584 0.98
16 23 0.051 9.3 8.5 0.8 1 21 908 928 908 929 0.95
17 23 1.1e-07 2.1e-05 26.3 0.8 2 23 1020 1041 1019 1041 0.98
18 23 1.3e-06 0.00024 23.0 3.9 1 23 1047 1069 1047 1069 0.98
19 23 0.015 2.8 10.1 4.4 1 23 1077 1099 1077 1099 0.98
20 23 0.0011 0.2 13.8 5.3 1 23 1105 1127 1105 1127 0.98
21 23 1.9e-05 0.0035 19.3 5.4 1 23 1256 1278 1256 1278 0.98
22 23 0.00022 0.041 15.9 2.1 1 23 1282 1304 1282 1304 0.98
23 23 0.0075 1.4 11.1 1.8 1 22 1310 1331 1310 1331 0.96

Sequence Information

Coding Sequence
ATGGCATTGCACGGGCAAAGCCAACCGACATGTCCTTTATGTAAAAGACAATTCCAGAGATTGGCAAGCTTGAAATCCCATCTAATGATGCATCAAGTAGAGGAGACGTTTGTTTGCAGGGAATGTTTGGCAGAGTTCGAAAAGGAGGATGAATACAACAAACATATGGAAACTCATAGCATAGCAAgacttaatttatttgaaagtatACCATATATTTGTtcatattgtaattatttattcgaGGATCCCAAGGATTATAAGGAACACGTTTCTTATCATATTAAGATAAAGAAATTAGTTTATAATCCGAGAAAAGCTAGGAGACGTACCACAAACAATAAAGAATACAGCCACAGGTGTTCAGTATGCAGTAAATCGTTTccgaaaaattgtttattggaaAGACATATGAGGATACACAATGGTGAAAAGCCATATACGTGTCCAAAATGTGATAAAGCCTTTGCACAGAAAGGTACCCTGCAAATACATTTAGTAAAACATTCGGGCCACAAACCGTATAAATGCACTTTATGTCCTGCGGAATATTTCCAAAAAGGAAATTTGCGCGTACACGTAGAAAAAACTCATACGGCGCCACCGAACATCGACAAAATGTATAAGTGCACGCAATGCACCTGCATATTTAGGAAGATCGCCTCGCTAAATGCCCACATCACGAAAGCGCACGGCGACATGAAGCACATTGACGAACTAACGGACATCAATGACAGAGTGAAGGCTTTGAGAGAGATGGCCGAGCAATTCCCCAATCCGAGCAAGGAGAACGTGGTCGCGGGAAACGCAAAAGTCGACCTGCTGAACGCGGAACCGAACGAGACTTTCGTTAAATTAGCGGAAAACAGCGCGGACGGTACATTGAGAAGATACGTTGTGAAGCAAAGGAAAGTGGGCGACACGAAATGGTTCATTTGCCTCTACTGTAGTAAGGAGTTTAAGAAGCCGTCGGATCTAATCAGACATATTCGAATTCATACTCGGGAGAAACCGTACAAGTGTAAAACTTGTAATCAAGCGTTCGCCCTCAAATCGACCTTATTATCACACTTGAATACTCACGACGGAAAACGGGAATACCAATGCTTGATGTGTTTTAAGTATTTCACCTCTGCGAGAACGTTAAGTGTGCATATAAAGAAACACGGGAAATCCGGTTCTACCACGAGTCTGAAGTATAAATGTTCGACTTGCAAGAAACTGTTCGGCACATTGGCGAAGGTGAGAAGCCACATGGAGGTGCATAATTGTAATAACGACGATATCGAGAGGAAGTCGCACGACGACCGGCTGGAACACCTGATTCCGTTAAAGCAACCCATGGTGGAGACCGAGAAAGGTTTAGTGTCTGTCCCGGCGCCGAAACCACGAATACCGGACGCAGAGATGGAGGAGTATAAGAATAGGCCGTACAAATGTCACAAATGCGACGCGGCCTTCACGAAACCGACGCACGTTAAGAGGCACATGCTGACGCACTCGGGCGAGAGGAATTTTAAATGCGATCTTTGCGCTAAGACATTTTCTACGTCTTACGCTCTCAAAGAACATCTGCGCTTTCATAATCCGGAGAAAAAATTCGCCTGCGGTCTATGCCCGCAAAAGTTCGTCGCGAAAGAATTGTTGAAGCGACATCAGATTAAGCATTCATCTGTAAGACCTTATATTTGTCCCTATTGTAAAAGGAGATTTAAAACGGCACCGTCATGTCGAAAACATATTAACATCCATGGAAGCGatACTAATTTACTTAATAGCGAATTAGAGATTATAACGAATACAAATCCTGCAAAACTGATTGATTTATCAGATACGATCCGAGACGATCCGTTCGATTTGGACACGCAAATTGATGAAGATGTCTTTTTTAAAGCAGTAAACACCCAAATGGAATTAAGACATGATGTAGTGTCGCAGTCGCGAAATATTAACGAAAAGAAAGGTCCGAAAAACAAGGGAAAATCTAAGAGATCCAAATACAAATCGCAAAGTAAGAAAaagatTACCGATTGCAGTATAACGTATAATCATGACGTCTTGAATTTACCTACTACTGCGCAGATATTCGTTTCGAAAGAAGGTCATTACACCATCATAATGCCGGAAACGAACGAAACTGAAACGCCTGCAGTTAACGCGAGTGTTGGCAGCATCGATCAAGGTCCTGCAGCAGCTTTTATTAGTTATGACGAATATCCGTCTGTTAATAACGATGTGTACAATACGATTTTATCGAACGTGAAGTTGCAAAACAGCGATCCAATTTTAATGAGTACAATAGGGGAATCGCAAGATTCTAATATACTATTCATGGATCCCACCTTGCCGCAATCGTCGGAATTCCAAAACGAAACTCAAAATTTCGAACCGTTCAATCCGACGATATTCAATACGCCTGTCGATTTAAACTTAGGTGTTCAATCCGCCGTCTCGAACGCAAACATACAAACGGTATTGTCATCGACGAGAAGTGAACAACTAATAAAATCCGCTCCAGTAAAACTGGGTTTCGCCGACGTATCGAATAAGAAAGGGATCAACGTCGATAATTCGAAACTGCTCCTGGCCCCCGAACACGTCACTTTGAACGATAACCTCATCATAACATTGAACGAAGACGAATTCGCCAGTATGAATTTCGGTTTAAATAACGGATCCAATCCCACCAACGATAATTTGAACTTAAATATCATGGACAGTTACGTATGCATGCTTTGCAAAGCCACTTTCGGCACGGGTCACGATTTAGAGAAGCATCAATGCGTCACAGTATTATCGAGTGAATTGGTTGACGATGATGGTGTCGAGGAAGGTTTAAATCCGATCAGTCTCGAAGAGAACCTGGATGATATCCACCAAAACGAACAGATTACTCTTATAACTGATTACAACGACCAGCTGCAAACCGCCCACATTGAGATCTCAACGGATGAACCTAGCTCGGATTCTCCAATTTTAAGGGAAACATTAAAAGACGACGGTTTTGAAGAAGCGAATGCGAAATTTCGATTAGATAAGACTAAAAAATTCGAGAACAAGTGCACTTATTGCGGTAAACCGTTTAAGAAAGCTTCAGATTTGatccgACATGttcgtacacataccggtgagaaacCGTTTTCCTGTAGCAAGTGTAATAAGAGTTTCTCGCTGAAATCCACTCTACAGTCACATCAAAGGACGCACAGCAATACGagaaataaagattttatttgttCAGTTTGCAATTGCAATTTTAGCTGCCGCGCTACTCTAAAAATCCACATGCGCATACATACAGGTGTAAAACCATACGCTTGCCATATATGCCACATGAAATTTAGAACATCATCGTCTAGAAAATCCCACTTGGCCACACACGCTAAAGAAACTAGACGGAACGAGTATAAGAACTCGACGAACGCCAACCAAATCAACCGCTATTTAGAAGGTTCCATGACCAACCAAGTTAAAATTCAAGACTCCAATATAACTACAGAACATatcGAAAATAACGAAATACAACACATGGAGGGCCTACCTATCGATTTACTGCAACAACTCCAGAACGCTGGATTACTGCTCCAGGAAACTGGTTGCGATGCCTTGAGCGACGGTTTGATGCAATTGAATTGCGATTCGGCGACTATACTGAACCCGAAAACCGCGAAAACAGCGCCAATTCAAGACGTGACGCTGAATGTTGCAGATACGGATTTTCCCGCGATTGCCGTGATAGACGATGGAAACCAAGCTGCGAAGAAATTCGAATGCAATTACTGCCACAAAACGTACACCACCAAAGCTGTCTTGAGAAAGCATCAGAAACGGCACAAGAAAGACTTCCAATGTCCGAAATGCGATAAACAATTTGACTCGCAGCATGTGCTGGACAAACACGTCAAATTGCATTCGGGTTACAGACCCTTCTCCTGTACCCATTGCGCCAATAGTTTCAGCGAAGAACGCAGTTTGAAAACGCATATGAAACGGTAA
Protein Sequence
MALHGQSQPTCPLCKRQFQRLASLKSHLMMHQVEETFVCRECLAEFEKEDEYNKHMETHSIARLNLFESIPYICSYCNYLFEDPKDYKEHVSYHIKIKKLVYNPRKARRRTTNNKEYSHRCSVCSKSFPKNCLLERHMRIHNGEKPYTCPKCDKAFAQKGTLQIHLVKHSGHKPYKCTLCPAEYFQKGNLRVHVEKTHTAPPNIDKMYKCTQCTCIFRKIASLNAHITKAHGDMKHIDELTDINDRVKALREMAEQFPNPSKENVVAGNAKVDLLNAEPNETFVKLAENSADGTLRRYVVKQRKVGDTKWFICLYCSKEFKKPSDLIRHIRIHTREKPYKCKTCNQAFALKSTLLSHLNTHDGKREYQCLMCFKYFTSARTLSVHIKKHGKSGSTTSLKYKCSTCKKLFGTLAKVRSHMEVHNCNNDDIERKSHDDRLEHLIPLKQPMVETEKGLVSVPAPKPRIPDAEMEEYKNRPYKCHKCDAAFTKPTHVKRHMLTHSGERNFKCDLCAKTFSTSYALKEHLRFHNPEKKFACGLCPQKFVAKELLKRHQIKHSSVRPYICPYCKRRFKTAPSCRKHINIHGSDTNLLNSELEIITNTNPAKLIDLSDTIRDDPFDLDTQIDEDVFFKAVNTQMELRHDVVSQSRNINEKKGPKNKGKSKRSKYKSQSKKKITDCSITYNHDVLNLPTTAQIFVSKEGHYTIIMPETNETETPAVNASVGSIDQGPAAAFISYDEYPSVNNDVYNTILSNVKLQNSDPILMSTIGESQDSNILFMDPTLPQSSEFQNETQNFEPFNPTIFNTPVDLNLGVQSAVSNANIQTVLSSTRSEQLIKSAPVKLGFADVSNKKGINVDNSKLLLAPEHVTLNDNLIITLNEDEFASMNFGLNNGSNPTNDNLNLNIMDSYVCMLCKATFGTGHDLEKHQCVTVLSSELVDDDGVEEGLNPISLEENLDDIHQNEQITLITDYNDQLQTAHIEISTDEPSSDSPILRETLKDDGFEEANAKFRLDKTKKFENKCTYCGKPFKKASDLIRHVRTHTGEKPFSCSKCNKSFSLKSTLQSHQRTHSNTRNKDFICSVCNCNFSCRATLKIHMRIHTGVKPYACHICHMKFRTSSSRKSHLATHAKETRRNEYKNSTNANQINRYLEGSMTNQVKIQDSNITTEHIENNEIQHMEGLPIDLLQQLQNAGLLLQETGCDALSDGLMQLNCDSATILNPKTAKTAPIQDVTLNVADTDFPAIAVIDDGNQAAKKFECNYCHKTYTTKAVLRKHQKRHKKDFQCPKCDKQFDSQHVLDKHVKLHSGYRPFSCTHCANSFSEERSLKTHMKR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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