Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 3.4e-05 0.0026 19.2 8.4 1 23 159 181 159 181 0.98

2 6 2.7e-07 2.1e-05 25.8 0.1 3 23 213 235 212 235 0.95

3 6 0.00012 0.0093 17.5 3.5 1 23 241 263 241 263 0.96

4 6 0.00081 0.063 14.9 0.3 1 23 269 290 269 290 0.86

5 6 0.061 4.7 9.0 0.3 3 23 298 320 296 320 0.88

6 6 0.0002 0.016 16.8 2.9 1 23 327 350 327 350 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	3.4e-05	0.0026	19.2	8.4	1	23	159	181	159	181	0.98
2	6	2.7e-07	2.1e-05	25.8	0.1	3	23	213	235	212	235	0.95
3	6	0.00012	0.0093	17.5	3.5	1	23	241	263	241	263	0.96
4	6	0.00081	0.063	14.9	0.3	1	23	269	290	269	290	0.86
5	6	0.061	4.7	9.0	0.3	3	23	298	320	296	320	0.88
6	6	0.0002	0.016	16.8	2.9	1	23	327	350	327	350	0.95

Coding Sequence: aTGAATGAATACGGCGACGATAACGTTTGCAGAATATGCTTTCAACGTCAAGACATAATATTCTCGCTGTTCAGAAAGCGAAAGGGTGCATCGCCGTATGACAAACTAGTCAAATACACGAAGTTAAAAATAGCAATAGACGACGGCGGTCCGGCTTCGATTTGTTTACAGTGCCTCACAGATCTCGATACGACCATAAACTTCTTAAATAAGTGcgaaaaatcaaatcaaatactGGCCATTCGATACAACTTAGTGTTTGAGAAAAAAGAAACTTTGAATTTGGAACGCGAGGTTCCCAACGACACTGTTCCTTGTTTTTCTCAAGAGGAGAGCATTGATTCGGAGACTATTCAGCCAGTTAAGGGGAATGTAGACACTCAGGAAGGAAAACAGATTTATTTAACTTCAGAGGTGCAATGTCCTCAGTGTGGCTCAAAAAGGCGCTGCAAGCATTGGGCCCCTCCAGTCACACATACATGCCAGTATTGCCATAAAGTGTTTACTAGGAAATTTAACTATACACTGCATATCAAGCGGCACCTCGGCGAGCGAGACTGGCCATGTCCGTCTTGTGGGACGCTGCTGCTTACTCAATGGTTGGCTGCTCGGCATTGCAGGCGCCCGAGACGCCCCTGCCCCGTGCCGGGCTGCGGGAAAACTTTTACTACAAACACTAATCTGGCTACACATATTAGAGTTCATAAtgGTGAACGGCCACATGATTGCGCAGAATGTGGGAAGAgtttctcctgtaaaaacaCCCTTAATGACCACATGAGGATACACACAGGCGTGAAACCCTACATATGCCCCGTGTGCGGCAAGCGCTTCGCCACCAACAAGCTGTCGTCGCACATGCTGTCTCACTCGACCGCCCGGCCGCACGCGTGCGCGGCGCCGGGCTGCGCGCGTAACTTCAAGTCGCGCCGCGCGCTCACACTACACTCCGCCACGCACGCAGCGGGGCGGCGCGCGCACGCATGCGCGGAGTGCGGGGCGCGGTACACGCACAGTCAGTCGCTGCGGAAACATGTCAGGAAGCAACATGCGCAGGTCAGTGGAGACGATGCTTGA
Protein Sequence: MNEYGDDNVCRICFQRQDIIFSLFRKRKGASPYDKLVKYTKLKIAIDDGGPASICLQCLTDLDTTINFLNKCEKSNQILAIRYNLVFEKKETLNLEREVPNDTVPCFSQEESIDSETIQPVKGNVDTQEGKQIYLTSEVQCPQCGSKRRCKHWAPPVTHTCQYCHKVFTRKFNYTLHIKRHLGERDWPCPSCGTLLLTQWLAARHCRRPRRPCPVPGCGKTFTTNTNLATHIRVHNGERPHDCAECGKSFSCKNTLNDHMRIHTGVKPYICPVCGKRFATNKLSSHMLSHSTARPHACAAPGCARNFKSRRALTLHSATHAAGRRAHACAECGARYTHSQSLRKHVRKQHAQVSGDDA

Sequence clustering based on sequence similarity using MMseqs2