Basic Information

Insect: Cecropterus lyciades
Gene Symbol: Hsf
Assembly: GCA_002930495.1
Location: MOOZ01000215.1:256107-265648[-]

Transcription Factor Domain

TF Family: HSF
Domain: HSF_DNA-bind domain
PFAM: PF00447
TF Group: Helix-turn-helix
Description: Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 6.8e-37 6.4e-33 113.9 0.0 1 100 14 113 14 113 0.97

2 3 2 1.9e+04 -3.2 0.0 16 40 119 141 116 148 0.68

3 3 3 2.8e+04 -3.8 0.0 74 93 524 543 508 545 0.60

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	6.8e-37	6.4e-33	113.9	1	100	14	113	14	113	0.97
2	3	2	1.9e+04	-3.2	16	40	119	141	116	148	0.68
3	3	3	2.8e+04	-3.8	74	93	524	543	508	545	0.60

Sequence Information

Coding Sequence: atgCGTTCAGTTGTGGAAATAGGTGCAAGCGTTCCAGCTTTTCTGGGAAAACTATGGAAACTAGTAAATGATCCGGAGACGAATCATTTGATTTCATGGAGCCCTggAGGCAAGACATTTGTCATAAAGAATCAGGCTGAGATTGCAAGAGAGCTTCTgcctttatattacaaacataataacatgGCCAGCTTTATAAGACAGTTGAACATGTATGGGTTCCACAAGATCACATCAGTTGAAAATGGAGGATTGCGTTATGAGAAGGATGAGATTGAATTTTCGCATCCATGTTTCATGAGGGGTCACGCATATCTCCTTGAGCATATAAAAAGGAAGATTGCAAATCCCAAGTCAATCGTCACAAGCAATGAGAATGGAGAAAAATTTTTACTCAAACCTGAGCTAATGAATAAGATGCTGGCAGATGTCAAACAAATGAAAGGCAAACAGGAAAGCCTTGATGCAAAATTTAGTGCAATGAAACAGGAGAATGAAGCTTTGTGGAGAGAGGTTGCTATTCTCAGGCAGAAACATATCAAGCAGCAACAAATAGTAAACAATttaattcAATTTTTGATGTCTCTGGTTCAACCAACTAGGGCTCCCAACTCTAACGGTAATAATGTTGGTGTTAAGAGGCCTTACCAGTTGATGATTAATAGTGCAGCACACAATTCTGGAGGTGGTAGTGCTTATCCTGGTAAAATGAAGAATATTAAACTCGACAAAGAAACCGTTTTAGAAGACCTTAATGAAGACAATTTGgAGGATGGCCCAACAATTCATGAACTAGCCCATGATGATGTATTGCACAATGAAGTGTCTCAGGATGCACTGGACACTTCAGGCTTTGTGTCTGTAGATTTATTTAACCCACTGATAAATGCAGCTTATAGCAACAACAATCAATTATCCTCTTCACAGTATCAAGTTACAATGGAAGATGGAGAAGATGTTTACACAGATGGTAGCAGAATAATATACCCCATCAGCCGTAGCAATGGCCAGTTAAGGACACCTGAAGCCGTGCCCATTGTTACATCACCATCTCCTACTATGCCCTCTCCTACATCTCCAATAGGTCAGACTGCTATGGATCAAGTTGCTAGCAATGTGAACACTGTATCACCTGGAACATCAAAGTCTAAAACGAGAGCAAACATGAAAAAGAATTTTACAGCAAATGTTAAATCCCTACTTACAAATAGCAATTTCAACAATTTAAATCCAACAGTTGACTTTAAGCTTCCTGCAGAGATATTTGCTAGTGATGATTCTGTCAGTGATGCCGGTGTGGCTGCGGCAGAAGAAGTCAGCGCTAATGATGTACTTGCGGAACACATGTTACCTGAGGAGCCTGTTGTACCTACCACAAAGGATAAAATGTTAGgaggtattaatataaaattggagACTCCCATTGAACAGACAAAACAATCTGGCAAGAAGACAAAGAAGTCCAAGGAAAATGAAAACTATTTGAATTTGGCAGACATAAAGACTGAACTTCAGGATGATTTTGACTGGAACAATATGACACTAGCAACAGTTAATAATAGTTCAAATGTGAATAGGTTACAAACTATGTATAGGAGAGATAACATCAATAAAAACCGAGAGGAATTAGCTTCCCTCTTCGGACCAAATGCAGCCAAGACAGACATTGATGATCACCTGGATACAATGCAAACAGACTTGGATTCACTGAGGGAGCTTCTCCGTAGTGACTCTTATTCATTGGACACAAATACCTTGTTAGGgCTGTTCGGGTCAGATGATCCTTTCTATGGCCTGAGTTTCAATCCAACTGATGAGCGGGCAAAGACAAGTGGCAATGcGAAGAAGCTGAAAGGTGACGGTTTGAATGTCCGCTGTGACGACGAGACGCCGTTTACTGAGGACGATGCTGAAGGGAATCAGCTAATCTCGTATACAGGGAATATTCCAGACTTTGAGGACATGAATATGCCCGACTTGGAAGCGGATAACTCTGAGCAGCCGGTTATGGCTCCGAGCCCTAGCAGTTCTACCTTGAACACGCCTCAATCGACGATCAGATCGCCTTTCAACACGCTTAAGCGATGA
Protein Sequence: MRSVVEIGASVPAFLGKLWKLVNDPETNHLISWSPGGKTFVIKNQAEIARELLPLYYKHNNMASFIRQLNMYGFHKITSVENGGLRYEKDEIEFSHPCFMRGHAYLLEHIKRKIANPKSIVTSNENGEKFLLKPELMNKMLADVKQMKGKQESLDAKFSAMKQENEALWREVAILRQKHIKQQQIVNNLIQFLMSLVQPTRAPNSNGNNVGVKRPYQLMINSAAHNSGGGSAYPGKMKNIKLDKETVLEDLNEDNLEDGPTIHELAHDDVLHNEVSQDALDTSGFVSVDLFNPLINAAYSNNNQLSSSQYQVTMEDGEDVYTDGSRIIYPISRSNGQLRTPEAVPIVTSPSPTMPSPTSPIGQTAMDQVASNVNTVSPGTSKSKTRANMKKNFTANVKSLLTNSNFNNLNPTVDFKLPAEIFASDDSVSDAGVAAAEEVSANDVLAEHMLPEEPVVPTTKDKMLGGINIKLETPIEQTKQSGKKTKKSKENENYLNLADIKTELQDDFDWNNMTLATVNNSSNVNRLQTMYRRDNINKNREELASLFGPNAAKTDIDDHLDTMQTDLDSLRELLRSDSYSLDTNTLLGLFGSDDPFYGLSFNPTDERAKTSGNAKKLKGDGLNVRCDDETPFTEDDAEGNQLISYTGNIPDFEDMNMPDLEADNSEQPVMAPSPSSSTLNTPQSTIRSPFNTLKR*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00673410; iTF_00795618; iTF_00887330; iTF_00971150; iTF_01082355; iTF_00970324; iTF_01438815; iTF_00166847; iTF_01437887; iTF_01359634;
90% Identity: iTF_01359634;
80% Identity: -