Basic Information

Gene Symbol
-
Assembly
GCA_900474235.1
Location
UCQR01094962.1:1-2885[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 1.1e-06 0.00011 23.0 2.2 1 23 10 32 10 32 0.98
2 8 1.5e-05 0.0015 19.4 2.5 1 23 38 60 38 60 0.98
3 8 7.1e-07 7.2e-05 23.6 0.3 2 23 69 90 69 90 0.97
4 8 1e-06 0.0001 23.1 0.3 1 23 96 118 96 118 0.98
5 8 5.6e-08 5.7e-06 27.0 3.0 1 23 124 146 124 146 0.98
6 8 1.2e-06 0.00012 22.8 2.1 1 23 152 174 152 174 0.98
7 8 2e-05 0.0021 19.0 7.5 1 23 180 202 180 202 0.98
8 8 2.7e-05 0.0027 18.6 1.5 1 21 208 228 208 229 0.95

Sequence Information

Coding Sequence
ACAACAACGGCACAGACGAACGAGGAGCACAAGTGCGACCAGTGTGCCAAAACTTTCGTCACCAGGGCCTCGCTCAAGGTCCACCTGCGAACTCACTCAGGCGAGAAGCCGTTCCGCTGTCTCGACTGTGGCAAGCAGTTCTCCCAGCTGCGCAATTACAAGTACCACCGTTCGGTTCACGAGGGTACCCGTGAATTCGCAGCCAGCTGTCCCGAGTGCGGAAAATACTTCAACGATCGTGGCTACCTCAGTAGCCACATGAAGATCCACCGCAACCGCAAGGAGTACGCTTGCACCGAATGCGGCAAAAGCTTCAATCAACGAGTCGCCTACAATATGCACGTGCGAATACATACCGGTCTCAAGCCACACCAATGCGAGCAGTGCGGCAAAGCTTTCTCGAGGAAGATGTTGTTAAAGCAGCATCTCAGAACACATTCGGGCGAACGGCCCTATCAGTGCCAGGTCTGTCACAAGGCTTTTGCCGATAGGTCGAACATGACTCTACATACGAGGCTACACTCGGGACTGAAGCCTTATCAGTGTACCTTATGCTCCAAGGCTTTCACGAAGAAGCATCACTTGAAGACTCACTTGAACTATCATACCGGTACCAAGCCTTACTCTTGTCCGAACTGTAGCCTCAGATTCTCACAGAGCAGCAATATGCGCACTCATTACAAAAAGTGCGCGCTGAACAATCCTAATGGTGTTGCAGCGGTGGCTACAGGAACGACTACAGCGGACAATAGCAAGCAGCTGGTGAAACAAGCGCAGCCGGCCGGTTCGGCTGCTGCGGTACAGCCGCCGGCATTGACGCCTCCGAACTCCGATCAGGAGTCCAGTAATAATATTAccgtccagcagcagcaacagcagcagcagcagcagatcgTCAAGGTCTGA
Protein Sequence
TTTAQTNEEHKCDQCAKTFVTRASLKVHLRTHSGEKPFRCLDCGKQFSQLRNYKYHRSVHEGTREFAASCPECGKYFNDRGYLSSHMKIHRNRKEYACTECGKSFNQRVAYNMHVRIHTGLKPHQCEQCGKAFSRKMLLKQHLRTHSGERPYQCQVCHKAFADRSNMTLHTRLHSGLKPYQCTLCSKAFTKKHHLKTHLNYHTGTKPYSCPNCSLRFSQSSNMRTHYKKCALNNPNGVAAVATGTTTADNSKQLVKQAQPAGSAAAVQPPALTPPNSDQESSNNITVQQQQQQQQQQIVKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00692333;
90% Identity
-
80% Identity
-