Basic Information

Gene Symbol
ZEB2
Assembly
GCA_963675205.1
Location
OY776091.1:1424368-1432268[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 2.5e-06 0.00044 22.3 6.0 1 23 162 184 162 184 0.98
2 6 7.9e-07 0.00014 23.9 0.1 3 23 217 239 216 239 0.95
3 6 2.3e-08 4.1e-06 28.7 1.3 1 23 245 267 245 267 0.98
4 6 1.4e-05 0.0025 19.9 0.5 1 23 273 294 273 294 0.97
5 6 0.03 5.2 9.5 0.9 1 23 306 330 306 331 0.91
6 6 0.097 17 7.9 5.1 1 23 346 369 346 369 0.95

Sequence Information

Coding Sequence
atggATGCGTTCAGTGACGAAAGTTCATGCAGAATATGTTTCAAAAAACAAGATACAGTGTACTCATTATTTCGTAAACGAAAAGGTATTTCACCGtgtgaaaaattatgtaaattaggtGTAAAAGCTGATGAAAATGATGGCGGTCCTTCATGCATTTGTTGTGACTGTCTAGCAGAACTGGATATTACTATAAACTTCCTAGAAAAATGCGAGAAATCTAATCAGATTTTCGCCAAACAGCTATCGACTACGCTAGATTTTGCTGAagaaatattaagttataagaCTGATATTGGTGTAGATGTCGAGAACAAAGCTTGTTACACAGACAGTAATCATGTAGATATCGCTCAGGAGACAAgtgtagataatatatttaatgaagaGGTGAATAGTAGTGATATCCTGAGCTTAGAGGAGGCACAGTGTGGCGAGTGCGGCTCAAAGCGTCGTTGTCGGCACTGGGCGCCTCCTACTACACATACATGTCCATACTGTCAAAAAGTGTTCactagaaaatttaattttaaattacatctTAAACGTCACAGTGGCGAGCGAGAGTGGTCATGTTGTGTGTGCGGCGCAAGCGCAGTGTCCCGGTGGCTGGCGGCGAGACACTGCGAGCCGCGCCGCCGACGGGCCTGCCCCGTGCCCGGGTGTGGCAAGACTTATACCACCAATACCAATCTTAATACACATCTTAGAGTGCACAatgGTGAGCGTCCATTCGAGTGTACAGAATGCGGGAAGAAGTTTACCAGCAAGAATACTCTCAACGACCATATGAGAATACATACAGgAGCTCTCCCGTACATCTGCCCAGTGTGCGGCAAGCGCTTCCGCACGAACAAGTTGTCGGCGCACATGAGCACGCACAGCggcccggcggcggcggcggcggcggcgcgccacgagtgcgcgcgcgccggcTGCGCGCTGCGCTTCGTCACGCGGCGCGCGCTGCTGCGccacgcgcgcgcgcaccacCCGCTCGTCGCTGCGCCTGTGACGTCACATGCCAGCCCCGCGCATGCGTGCGCGCTCTGCCCCGCGCGGTACCATCACAAGCAATCTCTCAATAAACATGTCAAGAAACAACACTTACAGGTTTGTATTCATACTGCATTTACTATTTCCAGCCAATGA
Protein Sequence
MDAFSDESSCRICFKKQDTVYSLFRKRKGISPCEKLCKLGVKADENDGGPSCICCDCLAELDITINFLEKCEKSNQIFAKQLSTTLDFAEEILSYKTDIGVDVENKACYTDSNHVDIAQETSVDNIFNEEVNSSDILSLEEAQCGECGSKRRCRHWAPPTTHTCPYCQKVFTRKFNFKLHLKRHSGEREWSCCVCGASAVSRWLAARHCEPRRRRACPVPGCGKTYTTNTNLNTHLRVHNGERPFECTECGKKFTSKNTLNDHMRIHTGALPYICPVCGKRFRTNKLSAHMSTHSGPAAAAAAARHECARAGCALRFVTRRALLRHARAHHPLVAAPVTSHASPAHACALCPARYHHKQSLNKHVKKQHLQVCIHTAFTISSQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00282811;
90% Identity
iTF_00282811;
80% Identity
-