Basic Information

Gene Symbol
ZEB2
Assembly
GCA_932526535.1
Location
OW052115.1:7612524-7616129[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 6.2 3.9e+02 2.0 7.1 2 21 163 182 162 183 0.93
2 9 0.00044 0.028 15.1 0.9 1 23 216 239 216 239 0.96
3 9 0.0021 0.13 12.9 2.8 2 23 245 266 244 266 0.95
4 9 0.078 5 8.0 2.3 2 21 270 289 269 290 0.92
5 9 0.0036 0.23 12.2 0.8 2 23 332 354 331 354 0.95
6 9 0.0013 0.082 13.6 0.5 1 23 387 409 387 409 0.98
7 9 0.0062 0.4 11.5 2.6 1 23 415 438 415 438 0.97
8 9 0.002 0.13 13.0 2.0 1 23 447 470 447 470 0.95
9 9 0.0027 0.18 12.6 8.2 1 23 479 501 479 501 0.98

Sequence Information

Coding Sequence
ATGAGCCGACAAGTTGATATAAAGGCGTTAGTGTCCCATATAGTGCGTGGAGACGGGTCAGACAGATGCCGAATATGCATGGGTGATACAACAGAGGGGCAAGTTCATTTAGAAGACACGGTTATGATGGACGGGGACAAGCCTGTGACGCTTGCTGAGCTGCTAGCAGTCATCACAGGAGTCGAGGTGCGGTTGGATGATGACCTGCCTGTAGGACTCTGCTCCGTATGCTCAGTGTCAGCCCTCGAAGCAGCAGACTTCAGGACCCAATGCCGGAGAGCTGCTTCTCAGTGGGAGACCACACTGGAACTCCTGAACAGCATACCAAATCAGACAGCTTTTAATAACCGCATCATTGCTATAGTTACTGAGAATACCATCAGCATCACTAAACACGAGAAAGAGGATGTAAAACCGGTTTTTAAAGAACCACCGGAGATAGTAAAGCAGAAAATCAAAGTTGAAAATGTTAAAAGTAATAAATGTCAGTGCCCTTGCTGTGGCAAGCGGTTTCTCTATGCTCAACATTTGTGCCAACATTTGAAAGAGTCCTCCAACAACCAACATGCGTGTCACATTTGTGCCGAAATTATGACGAGGCAGGAGCTGATATCGCATTTGTTGGACACCCATAACAAAGAGCCGTATGACTGCAAGAAGTGTCCAGCCATGTTTCGTACTTATATGCAGTATAAAGCACATCTTTCTAAGGCTCACGCGTCTGGGGCGTGTACCTGTGGCGAATGCGGCAGGAATTTCCAGAGCAAGCATGCTTACTACGCCCATTTATCAGTGCACACGCCAAAAGTCTGCCCCGGCTGCGACGAGCTGTTCAGAAACCAGAAATGTTACCACTATCACGTCAAACGCTGTTGCAATTTAGACAAGACGCGCTTAGACATTCATAAAACCAAAAGCAAAGTCACTATAACAGTTAAGAAGAAGAATAGGAGCATCAAAGTTGGCATGAGAGGAAGTACGGACTCCGAATGCATTTGCGATTACTGCAAAAAGAAATTCGCGGGAAAGAAATTCGTTGCGGCCCACATACAAATAGTACACATGAAAAATACTCACCGACCTTGCATTTATTGCGGAAAATTACTCGCAGCAGCTCACATGACCACTCACGTCAAAAAACACGAGACGACTGAGTCTTTCCAGTGTGGGCACTGTGGTATCGTGTTAAAAACGAAGCTAGGATACATCCAGCATGTTAGATTACATACCGGCGAACGTCCTTACGCTTGCAAGTTCTGTGGAGAATCGTTCTCCGCGTCCTCAAGGAGGTCAGAACACATCCGGAAATGTCATAGAGAATCGGAGATAGTTCTTAATCATGCTTGCGAGCATTGTCCGGCAAGATTTCGGCTGCCTTATAGGTTAAAAAAACATGTAAGCACCGTGCATGGGGAAGGAACGCAGTTACTGCAGTTTGAGTGCAATGATTGTCATGAGAAGTTCCGGAGCTGCAGGGCTTTGCTGCATCATAGCAGGAAGCATCAGGATCTTGAGAATACTCCGGCTAAAGTGCCGAGATTGAAGGAGGTCGCTTAG
Protein Sequence
MSRQVDIKALVSHIVRGDGSDRCRICMGDTTEGQVHLEDTVMMDGDKPVTLAELLAVITGVEVRLDDDLPVGLCSVCSVSALEAADFRTQCRRAASQWETTLELLNSIPNQTAFNNRIIAIVTENTISITKHEKEDVKPVFKEPPEIVKQKIKVENVKSNKCQCPCCGKRFLYAQHLCQHLKESSNNQHACHICAEIMTRQELISHLLDTHNKEPYDCKKCPAMFRTYMQYKAHLSKAHASGACTCGECGRNFQSKHAYYAHLSVHTPKVCPGCDELFRNQKCYHYHVKRCCNLDKTRLDIHKTKSKVTITVKKKNRSIKVGMRGSTDSECICDYCKKKFAGKKFVAAHIQIVHMKNTHRPCIYCGKLLAAAHMTTHVKKHETTESFQCGHCGIVLKTKLGYIQHVRLHTGERPYACKFCGESFSASSRRSEHIRKCHRESEIVLNHACEHCPARFRLPYRLKKHVSTVHGEGTQLLQFECNDCHEKFRSCRALLHHSRKHQDLENTPAKVPRLKEVA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00185736;
90% Identity
iTF_00809626;
80% Identity
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