Basic Information

Gene Symbol
HIVEP1
Assembly
GCA_947369205.1
Location
OX376303.1:94956561-94967384[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.00023 0.03 15.8 0.8 1 23 246 268 246 268 0.98
2 8 0.075 10 7.9 3.7 1 21 274 294 274 298 0.83
3 8 0.097 13 7.5 0.3 2 20 516 534 515 536 0.92
4 8 4.3e-06 0.00058 21.2 2.1 1 23 1239 1261 1239 1261 0.99
5 8 3.2e-06 0.00042 21.7 4.7 1 23 1267 1291 1267 1291 0.92
6 8 1.5e-05 0.0019 19.6 0.7 2 23 1747 1768 1746 1768 0.97
7 8 0.0021 0.28 12.8 1.7 1 23 1774 1798 1774 1798 0.91
8 8 0.00083 0.11 14.0 2.7 1 23 1816 1840 1816 1840 0.93

Sequence Information

Coding Sequence
ATGGAAAGCAGTGCCGATAGATATTTGCATAAGAAATTTAAAAAGCAGTTAAATATCGACTTGAACAATGTTGAAAAAGAAGAAAAAAAGGTCGGGTGTGGTGCAAAAGGCAACGAGCCTTCACTGCAAAATTGTGGCAATTTTGGTTCGGCTACGGGGATGTACATGAGTGATACTTCTGTTGCAAACAATGAGGATAATGTGCCAAAACTTAGTACAAATAACACAAATACTTTTAGCATCGTAGAATCTTCTAACGTAGTTAAGTCTTCCATATCTCATGTAAACATAGTTAATGCAGTAAAACAGAGTGAGAAAAGCGCGAACGTATTACAAGAAGATAGTGAGAGAAGTAAACAAGCTGGGGAATTAGTGGATCCACAATCTTCAAACAGTTGCATATCATATGTAATTCCAAATTCTAGTAGAGTAGAATATTACACACCACCAGAACTACAATTTAGAGCAGTTAATTTTGATACGAGATTTAATGTTTCAGAACCAATTCCTTCAGCTGATACGTCTTCCATTTTAGACAATGTATATTCTAAACAATACGTAACTTCGAAATTAGTTAATGTAGAGAAAGCTGGGGACATATCCTCCAACAGTAGCTTAGTCAACGATCACGGGACTAATCAGGAAGAATGTTATAATAATAGTAAGAGTGCAGAAACAAAAAACGATAATCATGTACCCGAACTAAGCGCTAACGAAAAAAGTTCCACCGGAAAGTATATTTGTTCCTATTGCAATTTGGCCTGTTCCAAGCCAAGCGTTTTGCAAAAACACATTCGTGCCCACACAAACGAAAGACCGTACCCATGCATCAGTTGTGGATTTAGCTTTAAAACGAGATCAAATTTATACAAGCATTGCAGATCGCGAACGCATGCGAATAGAGTTTTAGGAAACAAAGCTCAAGAAATCCACAACGAAATCGATGTAGATAGCCAAAATAAAATGGAATATGCAGAACTGAACAACTCGTTCGACTCGGTTCACGAAGACGCAATGGCCCATAGAATAAAAGATAAGCCTATCATGGAAGAACGGAGTTCGTGCATCGAAAAAATTGGACACGACGGCAAATCCAAACCCTACAAACCTCGCTTTCATACAGCCAAAGCTTTTTTTGACGATAATTCGAGAGATAATCAAAAGAACGTGGAAGATCAAAAAGTTCCGGTTACCGTCCAGAATAATAGACCTTCTAATTCTACTTTATTATCATTACACATCAGCGAAGTTATTAATAAAAATAATGCAATCATAAATTCTAACGAATCATTATTATTAAGAAAACGTTCCTTAGAAAACAATCAATTAGAACTTACAAGTAACGAATCTTTACCTCTTCGGCACAATGAAATAATTTATCCTCAACAAATCCAAACCAGCGACGAGCGAACGCAAGAAGATCAGCCACTCAATTTAACCAACAAAGGCCGAAAACGCTGTTTGAGCGAAGCAACTCCAGAACCCACCATCCAAACCAGTCTAATCAAAGAATTACTACTCAAAAACTTGTACGCCGATTCCATGCAATGTCCACACTGCAAAATGATCTTCCAAACGGTAACCGAGTTAGAACTGCACAAACTGAGAAGTTGCAAAGCTTTCATCAAATCCGGTGCGAGATATAGTCGAAGTAGCTCCGTGAACGTAGCCTCAATTTTAACGAAAAACAAAAATGCTTTTGCCGACATCCCGCACTTACAAAACACCACGTTTCCTTTAAAATCGCCGGGACCCTTTTTGGGAAAAACCAGACTGGTGGAAAGTGACAAAAGTAAATCGTTTTCGTTCGACGACGGCCTTCCAAACTTCCAGTCGAACTTGAACAATTCAAACGATCTCCTAAAAACTACCCTGCGGTACTCCATATCTCCGTTAACGATTCAACACGATAGAATTAAGAAAACTCCAATTAAAATGTTCGGTGGTGAAGTGAAAATAACACAAACTTCGGGTGAAATTAAAAGTTTCAAGATCGACGGTAAAGACGAATTCGAAAAATACGGTAGTAACGGTAATTTTCCTGAGTTTAGCAGTAGACTCAGCGAAAACCGCGTAGTTAAATCGTGTCTGCAATCGGGCGGCACGGTGGTGCAAAACAAACCTAATTATTCTGGAAAACAAGAGGCGATGAGATCGTCTCCCGAAATTATACGGGTATACGAAAATAAATCGCTTTCGCCAAACATCGACATTGTAAGTTTGGAAAAGAATAAGTTTACTTTCGAAAGGTCGCTAAGTCACGACTTGGATGGCGAACAAAAGTTAAATTCCGAACAGTCGGCTGACCGATTAAATTTTCAAAATGCAGCGAATGCTTACAAGTATCAGAATATTATGGATTTTAGTCAAAATGCCGCCAAGCAAATTGCTCCAAATATAAAGCAACCAAATCTCACTATTCCTGGACTACCGGTACCTAATCGACTTAGCTTTTCTCGGTCAACTTCGTTAATTTTTGAACCGAAACACAGTCCGCCGAAAATGTTCGATCCCATTTCGTTTTCTCGATCGCCCATGGAAAGTGCTCGCCCTAACGTGATAAATTTTTCTGAAGCATCGAAACCTCAGGAATCGGAAAAGCATTTGGAAAACATTCGATTTGCTCAGAAACAAATTTTATTACAACAAAATATGACGCACGAACCACCGTCTGCGTGTATAACAAGTCCAAGTGTATACAATCCTCTTCACTTATTGGTAAATGGAAAAGTAGTGCGTTATGTACCTGGAATTCCCGGCCCAGTAGCGGCAGAAGTACCCACGGACGTAGCTTACGGCGGAAATCAACCGACTTCAATTTCTTCGCACGTGCGGCCACAAAAATGCAATACTCGGTTAATCGTCACGGAGTCCTCGTCGTACTCCATGAAATCGTCCGAAACTCGTATGTCAACTGGTCCGGCTCCGAAAGCTAAATCGTCTGAATGTGCGATGCCTCCATACAGTGGTCTGCTACAAATCGATAAAAAACATTTGGAGCACGACCGACTTACCAAATCACCAAAATTTAGTGCTTTACACGTTAATGTTAGCGAACCCACAACACCAAAATTTTCCGAAATGAAATCTCCAAACATCATCAAGCCAACAGAAATTAAATCGCCTGCGCCAAAAAACGATATAAAGCCAATCAACAATTTGATACCCCCTAGCTCGATTATTGGTGAAACGGCGAAAAAGTTTTCCCGTCCAAATACTTTGGCACTAAAACCGAGCATAGCGGCTCATAAACAGCATCACGGCTTAACTCCAACAAAGTTTAATCAAATCCTAATCAGTCCCGATACTCCGCGCGTGGCGAAGAAATACATGCAACACTTTTTACATGGCAACTACTTCAGTTATTTGGGATTGAAAAGTTCCACGAAGCCCGTATATTGTACTTTAAATAAAACTCAACCTTTTTATGTTCCGCATCATTTTAAGAAGTTGAGCATGTATTCGGAATGGAGGCAGCAAGATAATAAAGGGGACAAATTGTACGCCAGTTGTTACGATCCTAGGCAGAGGCAGCAAAAGTATGTTATGGCTGGAAGAGGCACCGCGGATTTGATCGTCCATTCCAGTTATAAGTTTGTTGTCAACGAAAGCTGCTCCAGTAGAATAGAAGATCACAATAAAGCAAATTCAATTTTGGGAGGCTATGAATCAAATGAAGACTACACCTACGTTCGAGGTAGAGGAAGGGGACGTTACGTATGCGATCAATGTGGAATTCGTTGCAAGAAACCGTCTATGCTGAAGAAACACATCAGAACACACACCAATGATAGGCCGTACACTTGCAGTCACTGCAATTTTAGCTTTAAAACAAAAGGAAATCTCACCAAACACATGAAAAGCAAAGCTCACACTAAAAATTACACCGCAAGTAGCAGTTCGAGTTCTTCTACCCAACAAAGTGGAACTCCAAGTTCAGAATCTGATACCGACGATAGCGGAATGGATAGTAGTGATGAATCGACGAGGCAGCAAGAACACGAGGCGGCATACGGATTGCTCTCCTTGTCGCAAAAAACCACCCATAATAAAACCAGTTCGTCTTCCACCAGTTCAAATTCCGTTTGTTCTGTAGGCTTTAATTCCAGCGAAAATCGTTTCAATTTTATGAATACAGAACAAATAACGCAGGTGAACAACAGTAATTTCGCAAAAAATAAAATTTTGGATCAAGTAACGGTGAATTTTATCGGAAACAAAATTATGAACGAAATTCCTTTGAACATAGATCACGGTTCAAAGGAACTGCTAAATGTGGTTCAATTTTTGGGAAGGACTAACATCAGTAGGCCCTTGACTTACCCATACACTTCGGAGGTAACCGATACTTTGGAGAAATCACCAAGCTCGACAACGAAACTTCCCAGTAACTTTGAGAAACATCAAGAACAGTTCAATGTCGAACGTAGAAGTCATTCCTTATCTCCTATACTGGAACACAATAAAGTAACAACGGAAAGTGAAATCAGCTTTGAAAGCAATCACTCGGATAAGTATGATTTTACGGAAGAAGTTATTCAAAAGCAACCGAACCCTTCAACGACTCCTATTTTAAAAGTTAACGATTGTATTGTCAGCGACAGCCCCGTGAGTTTAAAACGAAAATTATCGGATTTGGACGAACAGGCTGTGGTAAAATTGCATAAACCTCACATCGAATTTGAAGCTATGGATTTATCGATGCCATCGTCTGCACAAAAACGCAGTCCCGTTCGGTACAACGGGGACTCTTTCAGTCAACAGGAAGCACGAATAAATCATCAAGTTCTCGATCACAGAAATTCGGATAATTATCAAGAATTTTACAACCACAACGGTGATGCTCACAACGCGAACGAAGTAAATTTTTTAAGTCAAGATAGCGTGGACGAGGTTGAAAATGTTGTAAATTTGAAAACTTCCGCACGTTACATACCAAACAACGATCAAATTAACGTTAATTATGTATATCAAGAAAGTAACCCGTCGATGGTAACGACCTTTACGGAAATACCTTCGATGGATTACGATAACAGTGCCATGGAAACGTTAGCTGACGTTGCCACCAAGCAAGTGAAGCTTGAAAAAAATACTTTAGCTAAAAGTGTCGCGTCTGAATATTTGAAGTTGGCCACTAAACAAGAATGCCAGTCCGGTGAAGGTATAAGAGAAGGAAACAATTTTATTTCGTCTTCGAAAGAAGTGAACGACATGATTGTTAAGTCGGAGGAAAATAAAAGTTGCAGCATCTGCGCTAAAAGTTTCAACAAGCCTTCACAATTAAGACTTCACATGAACATTCATTATTTAGAGAGACCTTTTCGATGTGATCCATGCTCTGTTAGTTTTCGAACCAAAGGTCACTTACAGAAACATGAAAGAAGTGCTAGTCATCACAATAAGTTGTCTTCCTCGCCATTGCTTTCATCGTCTGAACCTAGACCGTTTAAGTGCTCCGACTGCAATATAGCTTTTAGGATACATGGCCACTTGGCCAAACACTTGCGCTCGAAAATGCACATTATGAAATTGGAATGTCTCGCTAAAATTCCATTTGGTTTATATGCTGAGCTTGAGAGAGCCAACAGCTTGCTTACAGAAATCAATACAACTGATGGGGACCAATGCTTGGAGAGTTTAAAGGTGTTAGCAAAAAAAGTATTTATGAATGATCCAAGTAAACTGAATCAGTTGGACGTATCGTTGAACAATACCGAAGCATCAGATAGTTAA
Protein Sequence
MESSADRYLHKKFKKQLNIDLNNVEKEEKKVGCGAKGNEPSLQNCGNFGSATGMYMSDTSVANNEDNVPKLSTNNTNTFSIVESSNVVKSSISHVNIVNAVKQSEKSANVLQEDSERSKQAGELVDPQSSNSCISYVIPNSSRVEYYTPPELQFRAVNFDTRFNVSEPIPSADTSSILDNVYSKQYVTSKLVNVEKAGDISSNSSLVNDHGTNQEECYNNSKSAETKNDNHVPELSANEKSSTGKYICSYCNLACSKPSVLQKHIRAHTNERPYPCISCGFSFKTRSNLYKHCRSRTHANRVLGNKAQEIHNEIDVDSQNKMEYAELNNSFDSVHEDAMAHRIKDKPIMEERSSCIEKIGHDGKSKPYKPRFHTAKAFFDDNSRDNQKNVEDQKVPVTVQNNRPSNSTLLSLHISEVINKNNAIINSNESLLLRKRSLENNQLELTSNESLPLRHNEIIYPQQIQTSDERTQEDQPLNLTNKGRKRCLSEATPEPTIQTSLIKELLLKNLYADSMQCPHCKMIFQTVTELELHKLRSCKAFIKSGARYSRSSSVNVASILTKNKNAFADIPHLQNTTFPLKSPGPFLGKTRLVESDKSKSFSFDDGLPNFQSNLNNSNDLLKTTLRYSISPLTIQHDRIKKTPIKMFGGEVKITQTSGEIKSFKIDGKDEFEKYGSNGNFPEFSSRLSENRVVKSCLQSGGTVVQNKPNYSGKQEAMRSSPEIIRVYENKSLSPNIDIVSLEKNKFTFERSLSHDLDGEQKLNSEQSADRLNFQNAANAYKYQNIMDFSQNAAKQIAPNIKQPNLTIPGLPVPNRLSFSRSTSLIFEPKHSPPKMFDPISFSRSPMESARPNVINFSEASKPQESEKHLENIRFAQKQILLQQNMTHEPPSACITSPSVYNPLHLLVNGKVVRYVPGIPGPVAAEVPTDVAYGGNQPTSISSHVRPQKCNTRLIVTESSSYSMKSSETRMSTGPAPKAKSSECAMPPYSGLLQIDKKHLEHDRLTKSPKFSALHVNVSEPTTPKFSEMKSPNIIKPTEIKSPAPKNDIKPINNLIPPSSIIGETAKKFSRPNTLALKPSIAAHKQHHGLTPTKFNQILISPDTPRVAKKYMQHFLHGNYFSYLGLKSSTKPVYCTLNKTQPFYVPHHFKKLSMYSEWRQQDNKGDKLYASCYDPRQRQQKYVMAGRGTADLIVHSSYKFVVNESCSSRIEDHNKANSILGGYESNEDYTYVRGRGRGRYVCDQCGIRCKKPSMLKKHIRTHTNDRPYTCSHCNFSFKTKGNLTKHMKSKAHTKNYTASSSSSSSTQQSGTPSSESDTDDSGMDSSDESTRQQEHEAAYGLLSLSQKTTHNKTSSSSTSSNSVCSVGFNSSENRFNFMNTEQITQVNNSNFAKNKILDQVTVNFIGNKIMNEIPLNIDHGSKELLNVVQFLGRTNISRPLTYPYTSEVTDTLEKSPSSTTKLPSNFEKHQEQFNVERRSHSLSPILEHNKVTTESEISFESNHSDKYDFTEEVIQKQPNPSTTPILKVNDCIVSDSPVSLKRKLSDLDEQAVVKLHKPHIEFEAMDLSMPSSAQKRSPVRYNGDSFSQQEARINHQVLDHRNSDNYQEFYNHNGDAHNANEVNFLSQDSVDEVENVVNLKTSARYIPNNDQINVNYVYQESNPSMVTTFTEIPSMDYDNSAMETLADVATKQVKLEKNTLAKSVASEYLKLATKQECQSGEGIREGNNFISSSKEVNDMIVKSEENKSCSICAKSFNKPSQLRLHMNIHYLERPFRCDPCSVSFRTKGHLQKHERSASHHNKLSSSPLLSSSEPRPFKCSDCNIAFRIHGHLAKHLRSKMHIMKLECLAKIPFGLYAELERANSLLTEINTTDGDQCLESLKVLAKKVFMNDPSKLNQLDVSLNNTEASDS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00269170;
90% Identity
iTF_00270477;
80% Identity
-