Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 1.7e-05 0.0011 20.4 0.7 1 23 97 119 97 119 0.97

2 5 4.6e-06 0.00029 22.2 0.2 1 23 124 146 124 146 0.99

3 5 3.4e-06 0.00022 22.6 0.5 1 23 152 174 152 174 0.97

4 5 0.00021 0.014 17.0 3.0 3 23 182 202 180 202 0.98

5 5 0.0033 0.21 13.2 8.7 1 19 208 226 208 234 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	1.7e-05	0.0011	20.4	0.7	1	23	97	119	97	119	0.97
2	5	4.6e-06	0.00029	22.2	0.2	1	23	124	146	124	146	0.99
3	5	3.4e-06	0.00022	22.6	0.5	1	23	152	174	152	174	0.97
4	5	0.00021	0.014	17.0	3.0	3	23	182	202	180	202	0.98
5	5	0.0033	0.21	13.2	8.7	1	19	208	226	208	234	0.98

Coding Sequence: ATGGATCAGTTGTTAGAGAGAACATGTGATCCAAATTGGattgaaattaaaactgaaCCAGTGGAAGCCAATGATGTCGATGCAGAAGACTTTAACCCTACACCAATGGAATTCGTCAATATCAAGTTGGAGAACTTGAACAccgaagaagaaattaaaaccaaGGAAGTGGAAGCCAGTACAAACACGCCAGAAGACTTACATCATTCaattgacattaaagaagatGTTTCAATTCTTGAAGCGGGAGTAGATGAAGAATCTGCGGGTCAAACACGCccgcaattttttgtttgtgaGGTATGCAAAGCGCAATTTGCTACTAAATCACAACTGAAAAACCATGGAAGATATCACAGCGGGAAATTTTTCAAGTGcgaaatttgtgattataaagcTGTACAAAGAAGTAATTTGATCGATCATATACGAATTCATACTGGAGAAAAACCCTTTGCATGTGGAATATGTGGTCACAGGTTTTCACAAAGAGGAACTTTGAAAGTGCATTTAATGattcatacgggcgagaaacgtTTTGGATGCGACATTTGTGACTATAAGTGTTCAACAAAACGCCGTTTACAACTACATATCAGAACTCACACTGGGGAGAAACTCTTCACTTgtgaaaattgtgattttaaattttcacggAAACACCATTTGACAAGACATTGTCAAGTGTCTTGTAAAAATAAGATGCTAAAAAAAGGTTTAATCATTCGGAAGAGTGAAACTGACAGTTTCGCTTTTTGTGCCACCGATGGTACCCCATGA
Protein Sequence: MDQLLERTCDPNWIEIKTEPVEANDVDAEDFNPTPMEFVNIKLENLNTEEEIKTKEVEASTNTPEDLHHSIDIKEDVSILEAGVDEESAGQTRPQFFVCEVCKAQFATKSQLKNHGRYHSGKFFKCEICDYKAVQRSNLIDHIRIHTGEKPFACGICGHRFSQRGTLKVHLMIHTGEKRFGCDICDYKCSTKRRLQLHIRTHTGEKLFTCENCDFKFSRKHHLTRHCQVSCKNKMLKKGLIIRKSETDSFAFCATDGTP

Sequence clustering based on sequence similarity using MMseqs2