Basic Information

Gene Symbol
-
Assembly
GCA_949152465.1
Location
OX424437.1:4105550-4106692[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 1.1e-05 0.00073 20.9 8.5 1 23 103 125 103 125 0.99
2 10 8.5e-05 0.0054 18.2 9.8 1 23 131 153 131 153 0.98
3 10 0.0018 0.12 14.0 1.9 1 20 159 178 159 181 0.93
4 10 1.4e-05 0.00092 20.6 5.4 1 23 187 209 187 209 0.98
5 10 0.00011 0.0067 17.9 1.1 3 23 217 237 215 237 0.98
6 10 2.6e-05 0.0017 19.8 1.9 1 23 243 265 243 265 0.98
7 10 0.0083 0.53 11.9 3.1 3 23 273 293 271 293 0.98
8 10 0.0042 0.27 12.9 3.1 1 23 297 319 297 319 0.98
9 10 4.6e-06 0.0003 22.2 3.4 1 23 325 347 325 347 0.99
10 10 3.3e-05 0.0021 19.5 1.5 1 23 353 375 353 375 0.99

Sequence Information

Coding Sequence
ATGGAACTTTTGTCCaacgaagaaataaaaacaGAAGAATTGGAAATCAAACTGGAAGCCTTCCACCATTCCATTGAGGTTACAGATGGTCCAACGATGAACCATCAGGAGGTATTTTCCGAAGAAGGCGAAAATGGAAGCACagtcattaaaattgaaaaaacggAGGATGTTGATATCAAGCTGGAAGACGTCCATCATTCCATCGACATCAAAGAAGAGATTTCAATTAACCACTCTCGACCGGATCAAGATTGCAAACCGCAAATATGCAACCAATCACGAAATGGAACTGATGATAAACCGTTTCGgtgtaaaatttgcaattatagATGTACTAGAAAGGATCACTTGAAAaatcatttacgaactcataccggggaaaaaccgtttagCTGTACAATATGCGACTATAAATGCTGTCAAAAAGAGCACTTGAAAAGGCATTTACGAACacacaccggggaaaaaccctTTGAGTGCGAATtttgcggttataaatgttCCCGAAAAGGAGATATGAAAAATCATTTGCCAATtcacaccggcgagaaaccatttgagtgtacgagttgcgattataaatgttctagAAAGGAACAACTGAAgagacatttacgaactcataccggggaaaaaccgtttgggTGCAAATTTTGTGCTTATTATTTTTCCCGAAAAGAAGATTTGAGAGTTCATTTACggactcataccggcgagaaaccttTTGTGTGTAACATTTGCGACTACAAAGCTTCACAAAAACGACATTTGAAAGAGCATTTGCGAATTCAttccggggaaaaaccgtttggaTGCAACATTTGTGACTTTAAGTGTTCTCGTAACCAAACTCTGAAAGGTCATTTACTAAAACATacaaaaccgtttgagtgtaacatttgtGAATATAAATCCTCTCGGAAAGATCTATTGCAATGTCATTTAAGAAGTCATAGGGGTGAGAAACCGTTCGAATGTAATGTTTGTGACTTTAAGTGTTCTCGGAAAGGAAATCTGAAAGATCATCTACGAACTCACACCGGGGAGAAACCGTTTGAATGTTCTATCTGTAATTATAAATCTTCTCGGAAGCAAGATTTGAAAggtcatttacgaactcatactgtTAATAAAACGTAG
Protein Sequence
MELLSNEEIKTEELEIKLEAFHHSIEVTDGPTMNHQEVFSEEGENGSTVIKIEKTEDVDIKLEDVHHSIDIKEEISINHSRPDQDCKPQICNQSRNGTDDKPFRCKICNYRCTRKDHLKNHLRTHTGEKPFSCTICDYKCCQKEHLKRHLRTHTGEKPFECEFCGYKCSRKGDMKNHLPIHTGEKPFECTSCDYKCSRKEQLKRHLRTHTGEKPFGCKFCAYYFSRKEDLRVHLRTHTGEKPFVCNICDYKASQKRHLKEHLRIHSGEKPFGCNICDFKCSRNQTLKGHLLKHTKPFECNICEYKSSRKDLLQCHLRSHRGEKPFECNVCDFKCSRKGNLKDHLRTHTGEKPFECSICNYKSSRKQDLKGHLRTHTVNKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00270307;
90% Identity
-
80% Identity
-