Cfla025749.1
Basic Information
- Insect
- Cantharis flavilabris
- Gene Symbol
- lz
- Assembly
- GCA_949152465.1
- Location
- OX424438.1:28664633-28698243[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 7.6e-75 7.5e-71 236.8 0.0 2 129 44 171 43 171 0.99
Sequence Information
- Coding Sequence
- ATGCATTTACCTATTGGCTTAACGAATTGCTATTCGGTGTCGGAAGAAGCGTGGCCGAAAATTTCGATGATGGAACCCTCGGGGGGTTACACAAACAATCAAGATCCATGGTGGACCGAACATTTAATTCATGAAATCCAAGCGGAACATCCTGGTGAACTTGTTCGCACTGGAAGCCCATACCTGTTATGTTCGCAACTACCGACGCATTGGAGGTCTAATAAGACTTTACCAGTAGCATTTAAAGTTGTAGCTCTTGGTGACGTGGGGGACGGTACCGTCGTCACGGTTCGCGCTGGTAACGATGAGAATTATTGCGCCGAGTTAAGAAACTGCACGGCTGTTATGAAAAATCAGGTCGCTAAATTCAACGACTTGAGATTTGTCGGAAGAAGTGGAAGAGgCAAATCATTTTCGATAACAATTACGATATCTACAAGTCCTCCACAAATCGCAACTTACAACAAAGCAATTAAGGTGACGGTCGATGGTCCCAGGGAGCCGAGATCAAAAACGaatggTACTCAGTCATATAGGGCTTTAGGTTTAGGTCAAAGACCCTTTTTGGATGCCCCCTTTACGTCACATTTGAGAGATTTAGAAACGCTAAGACGAAAAGCTACACCTTCTTCACAAAACAGTGATACCTCGCAAGGGTCCTTTAAGTTAGATCCACAAgatCCTAATGGATTAAACGGCCCCCCAACACATTGTCAGCCGCCGTGGCCAGAATACACAACTCCTTATACGCCATACAGTCCACCACAGCCAAGTGGTTACTACGACCCGCATCAGGAACCAACGCATGCCCCCAGTCTGCATTTACCCACAGtaTTACCAGAAGTACCTTCACATGAATTTATTAATACTTCGCTTAATTCGCCACCTGTGTTTAGCAACACCAAATCTATAATTTCTGCAAATACGGAATTGGATCCTATGGTCTGCGCTGGTTCGCGCTACCCAGATAACAACACGTACTATCCTAACAATTGGGGAACGAATCCGAGTTACTCCAACAACTACAATTACTACAACACGCCTAATAACAATCAGCAATCGTATCCAACCACTCCTACTATGGTTCTCTATCCACATTTGTATTCAACagtaaatcaaaatcaaatacaCGTCCATTTGCATGGAAATAGTGAGAAGCTCGATTACATCAATGCCGATCCATTAACTTTGATGCCATCTAGAGGTACCATGGATATCGGAGTGACACCCGAAAGTCACGATATACAAACTAACAGCCAAATGACCACACAGCCACACACTCAAATCGAAGAAGACAGGGTACAAGTTCAAACAGATCCTTCGAGTGTGTGGAGACCTTACTAG
- Protein Sequence
- MHLPIGLTNCYSVSEEAWPKISMMEPSGGYTNNQDPWWTEHLIHEIQAEHPGELVRTGSPYLLCSQLPTHWRSNKTLPVAFKVVALGDVGDGTVVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFSITITISTSPPQIATYNKAIKVTVDGPREPRSKTNGTQSYRALGLGQRPFLDAPFTSHLRDLETLRRKATPSSQNSDTSQGSFKLDPQDPNGLNGPPTHCQPPWPEYTTPYTPYSPPQPSGYYDPHQEPTHAPSLHLPTVLPEVPSHEFINTSLNSPPVFSNTKSIISANTELDPMVCAGSRYPDNNTYYPNNWGTNPSYSNNYNYYNTPNNNQQSYPTTPTMVLYPHLYSTVNQNQIHVHLHGNSEKLDYINADPLTLMPSRGTMDIGVTPESHDIQTNSQMTTQPHTQIEEDRVQVQTDPSSVWRPY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01293346; iTF_00270822; iTF_00272234; iTF_00927277; iTF_00269525; iTF_00950495; iTF_00949571;
- 90% Identity
- iTF_01293346; iTF_00270822; iTF_00272234; iTF_00927277; iTF_00269525;
- 80% Identity
- iTF_00270822;