Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.8e-05 0.0038 19.0 0.1 2 23 105 126 104 126 0.96

2 6 5e-06 0.001 20.8 3.5 1 23 132 154 132 154 0.98

3 6 1.5e-06 0.00031 22.5 2.7 1 23 160 182 160 182 0.99

4 6 0.00055 0.11 14.4 0.3 1 20 188 207 188 210 0.93

5 6 4.1e-06 0.00084 21.1 0.7 2 23 217 238 216 238 0.97

6 6 7.5e-08 1.6e-05 26.5 0.5 1 23 244 267 244 267 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.8e-05	0.0038	19.0	0.1	2	23	105	126	104	126	0.96
2	6	5e-06	0.001	20.8	3.5	1	23	132	154	132	154	0.98
3	6	1.5e-06	0.00031	22.5	2.7	1	23	160	182	160	182	0.99
4	6	0.00055	0.11	14.4	0.3	1	20	188	207	188	210	0.93
5	6	4.1e-06	0.00084	21.1	0.7	2	23	217	238	216	238	0.97
6	6	7.5e-08	1.6e-05	26.5	0.5	1	23	244	267	244	267	0.98

Coding Sequence: ATGACGTCTATGTTCGAACAACAGATTAAGAGCGAACCCATGGGGTTCTATTCTGTTGCTTCCAGTCGTTCGGATGGATCCAACTCTATAGTGAATTTGTCCGACGATCGAGAGGACCTCTCTCAGCAGGAAGGTCATTTGCAGCCCCAGCAGCCGACGTTACAGTTGAATCAGCAGCAAAGCCAGCAGCAGAGTCAACAACAGACGCAACAGAATCAGCAACAGCAAAATCAGGGTATGCAGCAGGACTCGCCCGGTCGTCAGTCTACGGGTCAACAGACCGTCAAGGAGGGCTCACGGTCGAAGCCTCAACCTTGCAAAGTTTGCGGCAAGGTACTGTCCTCTGCTTCGTCCTACTATGTGCATATGAAACTTCATTCGGGGAATAAGCCCTATCATTGTACGGTATGCGAGGCGAGTTTTTGTCGCAAACCTTATTTAGAAGTACACATGAGGACGCACACGGGCGAACGACCCTTTCAATGTGAGCTATGTTTGAAAAGGTTTACTCAAAAGAGCAGCCTCAATACTCATAAACGGGTGCACACGGGGGAACGGCCGTACGCATGCGACATTTGCCAGAAACGTTTCGCTGTGAAGAGCTACGTCACGGCGCATCGTTGGAGCCACGTAGCCGAGAAACCGCTGGTTTGCGAACGATGTTCCCTCACGTTCACGTCCAAAAGTCAATTTGCGATTCACATCCGTACACACACCGCCAGTACCACTTACGAGTGCAATATCTGTGGACGTACGTTCGTACGTGACAGTTATCTGATAAGGCATCAAAATCGGGTGCATCGTGACATGAATCAGAGCAGCTCGAATCACAATCCGCCGACGCCGCAGAGTAGCGGCGCCGGCACTCCGGGCACCGGTTTCGAGAGTCCGGTCTGTGATTTGCGCTACAGCGAGGGACCCTCGTCATTGGATGGTCTCGCGGGAGCCAAGGGCACGGGCATAGCCGCGGAGATCGCTAGTTTAGCCAAGCAGAACAATCTACAGCTTCCACTACCGCTGCTACATCCGCAGACCACCAACTAG
Protein Sequence: MTSMFEQQIKSEPMGFYSVASSRSDGSNSIVNLSDDREDLSQQEGHLQPQQPTLQLNQQQSQQQSQQQTQQNQQQQNQGMQQDSPGRQSTGQQTVKEGSRSKPQPCKVCGKVLSSASSYYVHMKLHSGNKPYHCTVCEASFCRKPYLEVHMRTHTGERPFQCELCLKRFTQKSSLNTHKRVHTGERPYACDICQKRFAVKSYVTAHRWSHVAEKPLVCERCSLTFTSKSQFAIHIRTHTASTTYECNICGRTFVRDSYLIRHQNRVHRDMNQSSSNHNPPTPQSSGAGTPGTGFESPVCDLRYSEGPSSLDGLAGAKGTGIAAEIASLAKQNNLQLPLPLLHPQTTN

Sequence clustering based on sequence similarity using MMseqs2