Basic Information

Gene Symbol
topi_1
Assembly
GCA_948107755.1
Location
OX403624.1:15199328-15201665[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 1.3 1.1e+02 3.5 0.3 2 23 259 280 258 280 0.86
2 16 0.22 19 5.9 0.9 2 23 287 309 286 309 0.92
3 16 0.0025 0.22 12.0 0.2 2 21 316 335 315 336 0.92
4 16 1.6e-05 0.0013 19.0 0.8 1 23 343 365 343 365 0.97
5 16 7.8e-07 6.7e-05 23.1 2.8 1 23 371 393 371 393 0.98
6 16 0.045 3.9 8.1 0.8 2 23 405 427 404 427 0.92
7 16 0.058 5 7.7 2.6 1 23 443 465 443 465 0.96
8 16 0.0046 0.39 11.2 0.2 1 23 471 493 471 493 0.95
9 16 0.038 3.3 8.3 2.4 1 23 503 526 503 527 0.95
10 16 0.00077 0.066 13.6 0.0 1 21 542 562 542 563 0.93
11 16 0.0071 0.61 10.6 0.3 1 23 568 590 568 590 0.98
12 16 1.9e-06 0.00016 21.8 3.1 1 23 596 618 596 618 0.98
13 16 0.00017 0.014 15.7 0.6 1 23 624 647 624 647 0.97
14 16 0.046 3.9 8.0 0.7 1 23 653 675 653 675 0.89
15 16 3e-07 2.6e-05 24.3 2.2 1 23 681 703 681 703 0.99
16 16 5.8e-06 0.0005 20.3 4.9 1 23 709 732 709 732 0.96

Sequence Information

Coding Sequence
ATGACGAGTACAATTAGAGCCGATTCAATAAGCACGTCATTAAGTGACGAAGATGAAGAAGAGAATTACTTGGATGACGTTGAGGAGACGAGTTTTATTGGATCCCAGGAAGATCCATTATCAATGAGTGACATTATCGAGCAAGAGAGTAAATCAGCGTCGAACGTGGACGATGAAAATCCTGGTCTTTGTCGTTTGTGCGCGGGTCAAGCAATCAATCCCGTATACATTTATTCAGAATTTGGAGAATCAATGAGGCTCGCCCACAAAATGAACACGTGCTTGAGTGTGAAGATACGAAAAACGGATCATTTGCCGAAACAATTGTGTTACGTCTGCGTAGAGAAGATAAATTGGTGCGACGCTTTTGATGAGCAATGTATAAAAGCGGAAGAAACTCTGGAAACGATTTTATTGCGAGACGAAAAAGAGCGTTCTGGAAATACGGAAACAGGTGGAATGGATATTGAATGTGATGAAGGATCTTGTCCATTGTGCATCGAAGGTCACATGCGAACGTGTAACGATCTAAAAAACGTACAATCGAAATTGTACGACAGTGACGTCGTCATGGAAAGCAGCGACGAGGAAAAAGTTTTGGCGAATATCGAGACAGAAAGATCTATATCGAGAAACAATAACGATGCGCTTGGTGGCCTCGGTGTAACTCAACAGTATCTAAAATGCGGAGCTTGCATGAATCTTTATCACACGAAAGAAAGTCTCGACGCGCACAAGTGCAAGCCAAACGTTCAGCTGACCTCGAGACCTTGGAAATGTCTCGTTTGCGACGCGACGTTTCCATTCGAAGAACGTCTGAATTTTCACCTACAATTTCATAGTGGTGCCAAAGAGCTCTATTGCGATATATGTAAAATAACGTTCGCCAAAGAGTTGAAAGTATTTTATCACTACAAGCGTTATCACTGCGAAGACAAGAGCGTTTCGTGTTTACAGTGTGGTAAGTTGTTCCCAACTCAACAAGAATTGAAGATTCACGTTTGCGTCGATGGCAAAACTCGACCTCACGTGTGCGAGATTTGTAATAAAGGATTTTCCGACGGTTACACATTAAAGCGTCACGTGGTGACGCATCTTCCGGAGAAGCCTTACAAGTGTTCGCAATGCTCCAAAAGCTTCACGCAAAAGTCGCGTTTAAATAAACACATTGCGAGCCATGGTATCGTAATAGAAAATACCCAAGTAGCTTGGAAATGCGTCGAATGCGGTGAGACTTTCGAGACTTGTAACGAGGCTGATATTCACAATCGTAAAAATCACGACGAGAAAATCAGCCTGATCGAAGAATTGACAACGTCAAAAATTTATCATTGCGAATTCTGCAACAGTTATTTCAACGAGCTTGAAAATCTTCGGACACATGAGAACCTTCACGTTATCGAAAAACCTTACACTTGCAATATTTGCAATACGGTGTACAAGTCCTACGCCGAAGCTGTTTTGCATTGGAAAGAACATCCACGAAGTTTTCGTGTCGTTACAGCTTATCTGTGCGACGTTTGCGGCAAGGATATGAAAGAAATGTCACTTTTATACAAGCACCGACGAAAGAGACATCACGTTACGCCTCGGAAATCGGAAAACGAGGATTCCGTGAAGAAATACGTTTGTGAATTGTGTGGCAAAAGTTTCGATAAAGCCGAAGACATCAGGATACATGGGAGAGATCAATGCTCGAAATTTCCTtgcgacatttgtggcaatttattgccaactgctaattctttgcacgctcataaaagacgtcacagtggtttacgaccatacgtgtgtaatatttgtggcaaaagttacacacaatcgagccatatgtggactcacaagagatttcacatgggcgtaaaaccttacgcttgccaatattgcgatcaaagattcactataaaacctgatcttgctgatcacacgagaaaaaaacatacgagagaacgacctttcaaatgcgacgtttgtaacaaagcttttctcactggctcggttttttatcagcacagactcattcatcgtggtgatcgacgatataaatgccattattgcgaaaaagctttcactcgtaccgaagctctcaataatcacattaaaattcacaccggtgaaaaaccacacgcctgtgatgtttgtggaagatgttttcggcaaaaaggcgacatgagaaaacacagacgtacacaGCATAATGTTTCTAAAGAAGGATTGCCTTGA
Protein Sequence
MTSTIRADSISTSLSDEDEEENYLDDVEETSFIGSQEDPLSMSDIIEQESKSASNVDDENPGLCRLCAGQAINPVYIYSEFGESMRLAHKMNTCLSVKIRKTDHLPKQLCYVCVEKINWCDAFDEQCIKAEETLETILLRDEKERSGNTETGGMDIECDEGSCPLCIEGHMRTCNDLKNVQSKLYDSDVVMESSDEEKVLANIETERSISRNNNDALGGLGVTQQYLKCGACMNLYHTKESLDAHKCKPNVQLTSRPWKCLVCDATFPFEERLNFHLQFHSGAKELYCDICKITFAKELKVFYHYKRYHCEDKSVSCLQCGKLFPTQQELKIHVCVDGKTRPHVCEICNKGFSDGYTLKRHVVTHLPEKPYKCSQCSKSFTQKSRLNKHIASHGIVIENTQVAWKCVECGETFETCNEADIHNRKNHDEKISLIEELTTSKIYHCEFCNSYFNELENLRTHENLHVIEKPYTCNICNTVYKSYAEAVLHWKEHPRSFRVVTAYLCDVCGKDMKEMSLLYKHRRKRHHVTPRKSENEDSVKKYVCELCGKSFDKAEDIRIHGRDQCSKFPCDICGNLLPTANSLHAHKRRHSGLRPYVCNICGKSYTQSSHMWTHKRFHMGVKPYACQYCDQRFTIKPDLADHTRKKHTRERPFKCDVCNKAFLTGSVFYQHRLIHRGDRRYKCHYCEKAFTRTEALNNHIKIHTGEKPHACDVCGRCFRQKGDMRKHRRTQHNVSKEGLP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00265924;
90% Identity
iTF_00263711;
80% Identity
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