Basic Information

Gene Symbol
ZEB1
Assembly
GCA_001625245.1
Location
LUGF01026920.1:413892-425045[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.14 16 7.3 2.5 1 23 286 308 286 308 0.84
2 10 0.00022 0.026 16.0 4.1 1 23 315 338 315 338 0.95
3 10 0.017 2 10.1 2.0 1 23 369 392 369 392 0.97
4 10 0.0058 0.68 11.6 0.2 2 23 397 419 396 419 0.93
5 10 0.0054 0.63 11.7 0.3 2 20 432 450 432 452 0.94
6 10 1.5 1.7e+02 4.0 0.6 3 23 507 528 505 528 0.94
7 10 0.0079 0.92 11.1 2.5 2 23 544 565 543 565 0.95
8 10 9.2e-07 0.00011 23.5 0.5 1 23 571 593 571 593 0.98
9 10 0.057 6.7 8.4 6.7 1 23 600 623 600 623 0.98
10 10 0.0058 0.68 11.6 0.1 1 13 629 641 629 644 0.91

Sequence Information

Coding Sequence
ATGTTATATAATGGGAATGACGCGAATACTCCTGAAGATTTACAAGCAGTAGCTGATTTTAGAACTTGCAGAGTATGCTTGGGAATGGATAGAAAAATGTACCACATACGAGACTACAACCTCTTCCATCTGTACGAGCTGATAGTGGGAGTGATGgtgGAAACAGTGGACAGATTACCAAAGATGCTGTGCTGGGAGTGCACCAACAAATTGATAAGCATCAAGTCCTTCAAGGAGAGAGCACTACGATCACATGTGCTGTTGTCGAATAGGCTTACCTTGGATAATACATTGACAGTGGctgatattaaatcaataaataggataagttacaatttaaaatcaaatttaacattgaaatttaACGAACCCAATGAGTTTGATTTAGAACTAGACCATGAGAAGATGAATGGCGTACAAACTATTAAAATAGAAGTCAGCAAAATCAACGAGGAGCCCGTCAACAATATTGCCGATGAAGACGGAGTGGACTTGAAACTGGAAGACAGTGAAGTAAAGGACGAAGTGGATCATAGTTTTAGTGATAGTGATGATGTGGAACTTAGTGAGTTGAGGACTAAAAAGGTTAGGAAACGGAAGGCTAAAGTGAAAGTTAAAAAAGAAGTGAGTGAAGTGAAAAGGAGAAAAACTAGAGTGAAAAAAGAAGAAGTgaaggagaaagaagaagaGGAGTCGTTGGATATTATGGACAAGTTCAAGCCGTCGGCGGTGAAGCGCCGCGTGCGCAGCTACGACATAAGCGAGGCGCACTTCGACACGCGGCGGCTGAGCTACGAGGAGCAGATAGCCGAGCTGCAGCGGCGGCAGCAGTCGCCCGCGTACCTCGGCGCGGCCTTCAAGTGCACCGTCTGCTTCAAGGGCTTCAAGTCCAAGGCCACGCACGACCTGCATATAGTGAGGCACAGCGAGAAGTACGGCGCGTTCGAGTGCTTCATTTGCAAGCGGCGCTTCAAGAACTCGCGGCACCTGCGGCTGCACGTGACCAGCCTGCACACCGAGGAGTTCAGCTGCAAGGCCTGCGAGTTCGTCACGCGCTGCAGAGGCATAGCGATCGATCACCAGAAGTGGCACTCGGGCAACACGTACGCGTGCCCGCACTGCCCGTCCAAGTTCGGCAAGTTCACGTCGTACATGTCGCACCTGCGCATCAAGCACTCGTCGCGCTGGGTGTGCGAGCTGTGCGGCTACACGTTCGTGTCCAAGCGCGGCGTCGAGATGCACAAGGCCAAGCGGCACAAGCTGCAGGACGCCAACGTGAAGCTTGAGGGCCCGTACTGCGAGGAGTGCAACATCCGCTTCGTACACAACGACGCCTACCTGCGGCACCTCACGCAGTCTTCCGTGCACAGCAGCGACAACGACCCGAACCGCATCCGCAACGACTGGGGCTGCAAGGAGCAAGTTGGCGTAGTGAGGCGCGTGCGCAAGAAACGCGCCCCCGGCGTCATCGTGCACTGGGGCGCGGACCACCCCGACCGGCCCAAGCAGCTCATAAACTGCGAACAGTGCGGCGCGCAGCTGGACAGCTACCGCATGTACTCGCACCACTTCCGCGTGGCGCACCCCGGCCTCAACCGGACCAAGTTCTCGCGCGTCGCCGGCAACTGCATGTGCGAGCAGTGCGGCAAGATGTTCGCGTGCAAGGCGCTACTAGTGGACCACATGACGTCACACACGGGCGAGAAGCGCTTCAAGTGCGGCGCGTGCGACAAGGCGTTCACCAACAAGAACAACCTCAGCGTGCACCAGCGCGTGCACGGCGCGGAGGTGCCCACCTACCAGTGCCCCTACTGCGAGAAGCAGTTCCACTTCTACCAGAACTGCAACAGACACGTCAAGACGGTGCACAAGGGCGTGAAGCAGTTCCAGTGCGAGATCTGCGGCAAGGAGTTCACGTCGGCGGCGGGGCAGCGCGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCCCGCCTACCGGGAGTGAGGCCCCGCCTACCGCGAGGGAGTGCCTCGCATCCATTATGA
Protein Sequence
MLYNGNDANTPEDLQAVADFRTCRVCLGMDRKMYHIRDYNLFHLYELIVGVMVETVDRLPKMLCWECTNKLISIKSFKERALRSHVLLSNRLTLDNTLTVADIKSINRISYNLKSNLTLKFNEPNEFDLELDHEKMNGVQTIKIEVSKINEEPVNNIADEDGVDLKLEDSEVKDEVDHSFSDSDDVELSELRTKKVRKRKAKVKVKKEVSEVKRRKTRVKKEEVKEKEEEESLDIMDKFKPSAVKRRVRSYDISEAHFDTRRLSYEEQIAELQRRQQSPAYLGAAFKCTVCFKGFKSKATHDLHIVRHSEKYGAFECFICKRRFKNSRHLRLHVTSLHTEEFSCKACEFVTRCRGIAIDHQKWHSGNTYACPHCPSKFGKFTSYMSHLRIKHSSRWVCELCGYTFVSKRGVEMHKAKRHKLQDANVKLEGPYCEECNIRFVHNDAYLRHLTQSSVHSSDNDPNRIRNDWGCKEQVGVVRRVRKKRAPGVIVHWGADHPDRPKQLINCEQCGAQLDSYRMYSHHFRVAHPGLNRTKFSRVAGNCMCEQCGKMFACKALLVDHMTSHTGEKRFKCGACDKAFTNKNNLSVHQRVHGAEVPTYQCPYCEKQFHFYQNCNRHVKTVHKGVKQFQCEICGKEFTSAAGQRXXXXXXXXXXXXXPRLPGVRPRLPRGSASHPL*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00688111;
90% Identity
iTF_00688111;
80% Identity
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