Cmac001333.1
Basic Information
- Insect
- Callosobruchus maculatus
- Gene Symbol
- SPO11
- Assembly
- GCA_900659725.1
- Location
- CAACVG010001546.1:259866-298654[-]
Transcription Factor Domain
- TF Family
- GCM
- Domain
- GCM domain
- PFAM
- PF03615
- TF Group
- Beta-Scaffold Factors
- Description
- GCM transcription factors are a family of proteins which contain a GCM motif. The GCM motif is a domain that has been identified in proteins belonging to a family of transcriptional regulators involved in fundamental developmental processes which comprise Drosophila melanogaster GCM and its mammalian homologues [PMID: 8962155, PMID: 9114061, PMID: 9580683, PMID: 10671510]. IN GCM transcription factors the N-terminal moiety contains a DNA-binding domain of 150 residues. Sequence conservation is highest in this GCM domain. In contrast, the C-terminal moiety contains one or two transactivating regions and is only poorly conserved.The GCM motif has been shown to be a DNA binding domain that recognises preferentially the nonpalindromic octamer 5'-ATGCGGGT-3' [PMID: 8962155, PMID: 9114061, PMID: 9580683]. The GCM motif contains many conserved basic amino acid residues, seven cysteine residues, and four histidine residues [PMID: 8962155]. The conserved cysteines are involved in shaping the overall conformation of the domain, in the process of DNA binding and in the redox regulation of DNA binding [PMID: 9580683]. The GCM domain as a new class of Zn-containing DNA-binding domain with no similarity to any other DNA-binding domain [PMID: 12682016]. The GCM domain consists of a large and a small domain tethered together by one of the two Zn ions present in the structure. The large and the small domains comprise five- and three-stranded beta-sheets, respectively, with three small helical segments packed against the same side of the two beta-sheets. The GCM domain exercises a novel mode of sequence-specific DNA recognition, where the five-stranded beta-pleated sheet inserts into the major groove of the DNA. Residues protruding from the edge strand of the beta-pleated sheet and the following loop and strand contact the bases and backbone of both DNA strands, providing specificity for its DNA target site.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 0.00036 6.9 6.7 0.0 1 17 42 58 42 61 0.91 2 4 1.1e-30 2.2e-26 92.6 0.9 81 140 60 119 58 119 0.97 3 4 0.44 8.5e+03 -3.3 0.0 1 29 803 831 803 848 0.81 4 4 0.16 3.1e+03 -1.9 0.2 55 88 1709 1741 1708 1771 0.77
Sequence Information
- Coding Sequence
- ATGCATGGATTGGAGAGGCACACCCCCACCTCCCCTGGCATGTCTTGCCGGGCATACGTCGGCACCCCAAATTCCACGGCCGACTGGGATATCAACGATAGCTCTGTGCCCAGAATCAACGAGTTCGACCCTTTCTCAGAATGGGCCGACGGACATTGCCGGCTAGTCTACAGGTACGGCAAACCATGTCCGAACCGAACGTGTCCCGGGCGGTTGGAGATCCTGCCGTGCAGGGGGCACTGCGGCTACCCCGTGACCCACTTCTGGAGGCACACCGAGCACGCCATCTTCTTCCAGGCGAAAGGGGTGCACGACCACCCCCGGCCCGAAGCCAAGGGGGCCAGCGAGGCGCGCAGGACGCAGGGCGGGGGCGGCAGGCGCGTGCGCAGTCTCGCCGTCGTCCTCGCCAAGGAGGCGGCACTCGGCAACAAGTTGATGTCACTACGAGAACCAAAAAGGCAATGCAGGGAAATTACAAGTCAAGTGTCACGAGAACTGAACGCATCATCATTATTTGGAGATTCTAAGAATGGTTACTGCTCGTGTCCCCCTTTCGAGTGCATCTGCAACTACCAACAACCAGCGCCAGCAACTCCTCAGCAATTCCCAGCATCTCCTAACTCGTACCCCCACCAACTCCCGGAGTGTTACTGGACGCAAGATCCTGTCCACCCTCAACTTTACCACTACTCTGACAGCGGAGTACCGAGTACGACTCACCAGTACGACTTCAATTCCATTAGTACCGAACTATTTCAACCTGAAGAGATCTTTTCCATGGAGCAGCCAGTCAAACAGGACCCCGCGCAAAATGATAGCGCAAGAAGTCCTCCAACGCTACTGGATCTGGGATCCGGAACCATCCACAGAGAGTTCAAGTCTGAAGACTACTGGAACGGAGCATTGGGGAGTCTTTTAGTTAATGATGATAGTAATAACAGTAGTAACAGTAGGTTTAACGTTAGTCAAAGCCCTTTGCTCAACAACAACCTACCGCAAGTTGATCAGAATGTTTACCCAGAGATCAAAGTTGACGGCAACAATCAGTATTCTATGTCAAAAATGTCTTTGTACCAACATTCGGAAACCCCTTACAAGAGTTTCGAGGGCCATTATTTTCTTGAGGACAAAGCTTTTCAGTCCTGTGAACCGTACCAAACACCCAAAACTTACCATCCTAAGACATCGACGCAGGACGAATATATTGATCTAGGTCAATTTGGTGAATACAATAGCTATTTAAGCAGTTATGACCCTAGCAAGAGTTTCATACAAAGACTCAAGAAAAGAAAATCGAACACAGTTCACAGTCCCgaagagaaaaaaattaaacttgatGAACAACATGATCAAAGAAAACTCAAACCTCCATGTAAGAAGAATAAAGCAAAAGATCCATTTACTGAGGATCCTAAAGTACATCAATCAAAAATAACAACTCATTACAAGATAGTGAAAGGAAGTCTGTCCAAGCCAAATACTACAAAAAAGAAACGAAACTGGGATAGTTGCTCTTCAGATGAAGAGTTCTGGATATCTAAGTTTGCATTAAAGTGTAGCAAGAGTACCAGTGATATTCCAATAAGTAGTGAAACAGAGAATACTGAAAAGCAACATAACAGTCTGCCAGTTACTCGTGAAGAAGTTACAAGAGGCCTAAGTGTTCTTTCAAGAGCTGTAAGACCAGGTTTATCATCGAAGAAAGACAAATGTCAGGTAGGAGATGTGTTGAAAAAGATCgacaaagaaaaaagaaaaccatCAGAACAGGTAAAACCTGAAACCATGAATAATAATTTAAGTTATTTAAATTATTTCACTGTAAGAGCTAATGATAATGCATCAAATAAAAGAGAATCAGGTAGCCATGGTAGACCTGATAAAATTGTGTCTAAGGTAGAAGGTATAAAGAACAGAAAAGATGCAATGCAGCATCATGATAAAAACGATATTGAAGACAAAGAGACAGTCAAAGAAATTATCGATAAGTTGGTCAAAAAAGGAAAGGATGGAAATAGAACTAAGACTTTTGTTAAAGGTATGCATTCAGGTATGGCATTTAATATATTTGACAAGATTCAACAGCATGATCAGGAGTTTGACCTTAAATGCCAAGATTTATCAAGTAGCAAATGTTTAGACATGAGAACTCTGCATAAAAATGATACTACATCTTTTAAGGTCAGCAATGAAAATAAAGACATTAATAATACCAATCATCACCAAAAACCAGTGATGCCTAAACTTCTAGATGAAACTTCTACTATTGAAACTATTGTAGAAGAAACctttcataaaacaaaaaataaggaaACAAATGGCAAAGCATCAccacaaaacaaccaaaattttaaaaataatattttctcaaagaCAATTAAGAAAGCACAAATTGACAATGTTAGATATGATAAATTTAGTAAATACTCTAACAgtggtaaaaataaaaaatatgtcaaaGCGAATGAAGAAATGTGCAAGTTGATATCCAAATTAACAGGAGAAAGAGCAGTAACAGAACAAGGAAATGAAGAGATCCAAAAACTAGTCACTAAATTAAAAAACCAGACAGAAGAAACTAATTCTGTTAGTGAAACTTCAAAGGATAAGAAGGAACTTCTTGCAGCTACTGTCAAAAACTCTTGCTGTGATAATGAGAAATATGTTGCCGAAAGGACATGTACTTACAATGAGGTACCAATACATTGTAACACTTCTGGTAACTTAAAGATAGTTGAAAGGCAGAATGAAAAACCGAACAATCTAAAATCTTTGCCATTGAAGCAATCAACACCTCTACAGTTATTCAATAAAGCTGCCAATGGAATTGAACAGGATAAATGTggaaattataaatataataataaacaagagtattcattaatttgtaataaaagtgGAAAGGTGGTAAGTTTCGAAGAACATACAGAAATATCTCAAGAAATTGACTCAAATAACAACATATCTTCAGAAATGGAGCAAAAAGatgaatatttagagaaaagtaGCTCAGACTCGGTAAAAGCTTGTGAAGGTAAGCAATTACTGAAAAAGAGACAAGCAGTTGGACAAAATTACAGTATGCCTACAGAGAAAGAAAGAATAATGCATATGCTCCACTACAATACAAAGCTTACTGGGAGTGTTAAAAATACACAACAAATGGAAAATATCTTTAAAGACATGAAACCTCTATCAGAAATTAGACAAAGTACTCCAAATAGTTTAGGTGTGGAACTTGGCAGTGGTAAAATAGAAGATTATGACATTCATAGTATTATAAGAAGATTGGCAACAGATACTGAGAAATTTGAAGTAAATAACGATCAAAATAGAACTAACACACTGCATCAGTCATGTTTTTTAGAAAGTAATGAAGCTAAGGAACTAGacgtaataaaacaaaatatgggAAATCTTCAAGATACAAATCAGGTAGCTAATATCAAGAACAGTACTTTGGAGAACGCTAATGATCACATTTCGGTACTCTATTTCAAAAATCGATCTAAATTTAGACATAAGCAGAACTCGAAGGAAAACACAATTGCAGGTGTTTTGCACGACAATGACGGTATTAAAGCAGCTTCAACAAATACTAGTTTATCAGTTTCCTTTGACCCACATGAAGAAGGCACAGATAGATTATTTAACAGTGTAACAAGTGATGAAAGCAAGAATGTTCAAAAGGAGAAAGAATTCCCCTTTACAGcccctattatgaatatcatAGCCAAACTTAACAAAAATTCATTTGATTGTCCAACAAGAACTGATGCAGTATATTCACAAAATCCACTGAATAGTGATGTACCTAGGCCTTTTACTGAAGAAAATAAAGAAGCACAATCCGTACAAGGGAGCCAGACCAATGCTCTGACAAATAAAGAAATTATGTCATTGAATAAGGTTCCAGATCCGGGATGCATTGGGAATAATACATTCAAAAAGCCTAAGGGTAACATTGAACAGAAACGGTTGACAAAGGAAAATAACAGTAACAAGCATGTTGAGAAAAATGTAGTATGTCTTCCAATTGGAGGCTTAGCTGTAAGGCAGAAAAATGCAGTGGTTGCACGGGACCTTTATCACAAACATGTATTAACACCAAATGAGAAAGTTCCGTGTGATGAAAAGTTTATAGACAGAACAAAACTTGACGATGGTGTAGACAAACTAAGACAGATACAATCAAAAAAGCATTCTGAAGAGATTAAGCATCTCATAATGGAAAATTCTAGTGCCAGTTTATTAGACGACCCTAAAACTGACGTGGAAAAACACGAGATTCATGCCAATGACAATTTCTTAAAAATATTCCGGAGACAAACCAAAATATTGGACAACGAAAGCTTGAGAGTTCAAAATGTAACAAATGTCTCATCAGAACATAGTGTTGGTACTATTGACACAGTATTTGCAGATGATCAACAGAAATTAGTTAATAAGATTTTGTTTGAAATAAGTTGTGGGAAATCAGATGAGCCCACTAACTGCTCAAGTAATATTCTCTCCCCAAAAAAATCTAATGGTGATCTTCGCAAAGATGTGaaaagacaagaaataaatttaGAACGTAAGAACGAAATTCAGTCTGTGACTGATGTCCAAAGTTCTAGAGATGTTTGCAAAAAATCTATTTCTATAAAAACAACTGAAGACGAAATTGTGTCATCAAGTATGTTGCTCAAAACAAAACGTAATATTGTACAGAATGAGGTAAAATCCGGAACAAATATTACCGAGGATCAAATTATTAACAATGTGTTGCTTGGGACAACCTGCCATGAACTAAAAAGTCAGCCAAATACGACAATCCTTAAAGATACGTTTATCTCTTCATCTCATTCGGTAACTAATTGTGAGATCAACGTAGGATCAGAGTCTTGTGTACATACTCAGAATTCTAAACCATTCAATCACCCTAATCAATCATCGGAGGATGAATTATCTGACAAACTCTGGATTAAAAACTCTGTCTTTTTGAAACAAAGATCTGATACATCCCAACTAAGTCAGTGTCTATTAAACGAccaaaaagatgaaaataataagATTATAGAAAACCATGACTTGTCGAGTCATTCGATTTTCGAACCTGAGTCAAATCTTGAAAACCCAATCCAAAGTTGTTTCCATGAGAAAAATAGAGAACTACTTATTCGTCCAAAAATGAATGATGACGTCAATAATAATGTTACCAAAAATTGCGACACACGTAATAGTCTTTTGTTGTCAGCCACAAAAAGTAGTGAAGCAAATCAGACCCAAATAACGTGCATATTCGATAAAAATGAACAAAACAATATGATGCCTAAAAAGACTCACATAAGCATAAAAGCAAACGAATTGTTGGCTGATGAAGAAATTAACAGAATACTAACAAAGAACTATGAGCAATGCATGAGATCGAAAGAGAACAACGCATCACAAACTCGAGATGACGCCATTtctaaattattgaaaaagactGAAGACCAGAAGCCAAAAGCGAAagacattataaaaaaatacaggaaAGGCAAGCTGAAGATATATCgcttgaaaaaaatgaaaaaaccgaGCAAAGATTTAGATAAAGTAGAGGAAAATTTGGACTTTGACGatgtatttaaaaaacttacaCAGGACTTTCAAGAGCCAGCTAGGTGCAGCTCCCCATGTGAGTCTTTAGTTTCTACACCATCTTCGTATAAATCTGTCAGCACATTGAGATCCGAGACACCTACTGAGTCGAAAGAACTCAGTTCGTTTCAAAGAAAGTTGCGAGAAGGTATAGAGCTCTACTACCAACTGAAAGATATGATCAATGGTCAAGGTGTCGTTGATAGAGCTATCAACTTGGTGAGCTGTTTGTTGAATGTTGGAATGTGGGCCTTGAACATTATAGCCCAGAAAGGATtaatttttggaaatttgaagATCATGCTATCATCTGGAGAAACAATCAATTGTAACGTTCCAGATGCATACTTCATACTAGTAGTTGAAAAAGAAGCCATATTCCAGAAACTTTTGGAAGAAGACATTCCTAACAAACTTACAAGACCCTTCATAATGATGACGGGTAAAGGGTTTCCTGATTTGAACACTCAGTTGTTCCTTAGGAAGTTGTGGATTATAATGAGAATTCCAGTATTTATTCTGGTGGATGCTGACCCCCATGGCATCAACATTATGTTGAACTATAGGTTCGGTTCAGTTGCAAATGCCCATGTGTCTCATCATTTAGCAGTGCCAAAAGCCAGGTGGTTGGGACTCCTTCCCTCAGAAATTACAATGTTCAATGTAAAAAAGCAAGCAATGAGTACCAACGAGCAGAAGATGGTTGAGAAATTATTAAACACCCCTTATATGAAAGATAATCCTGGGATTGTAGAGGAACTGAAGATCTTACAGAAAAATAACCTAAAGGCTGGTATTGAAGGACTTATTAAGACTGATGTGTTTCTAAGTCAAGTGTACTTACCGCACAAGTTTCTTCATCgtgattttatataa
- Protein Sequence
- MHGLERHTPTSPGMSCRAYVGTPNSTADWDINDSSVPRINEFDPFSEWADGHCRLVYRYGKPCPNRTCPGRLEILPCRGHCGYPVTHFWRHTEHAIFFQAKGVHDHPRPEAKGASEARRTQGGGGRRVRSLAVVLAKEAALGNKLMSLREPKRQCREITSQVSRELNASSLFGDSKNGYCSCPPFECICNYQQPAPATPQQFPASPNSYPHQLPECYWTQDPVHPQLYHYSDSGVPSTTHQYDFNSISTELFQPEEIFSMEQPVKQDPAQNDSARSPPTLLDLGSGTIHREFKSEDYWNGALGSLLVNDDSNNSSNSRFNVSQSPLLNNNLPQVDQNVYPEIKVDGNNQYSMSKMSLYQHSETPYKSFEGHYFLEDKAFQSCEPYQTPKTYHPKTSTQDEYIDLGQFGEYNSYLSSYDPSKSFIQRLKKRKSNTVHSPEEKKIKLDEQHDQRKLKPPCKKNKAKDPFTEDPKVHQSKITTHYKIVKGSLSKPNTTKKKRNWDSCSSDEEFWISKFALKCSKSTSDIPISSETENTEKQHNSLPVTREEVTRGLSVLSRAVRPGLSSKKDKCQVGDVLKKIDKEKRKPSEQVKPETMNNNLSYLNYFTVRANDNASNKRESGSHGRPDKIVSKVEGIKNRKDAMQHHDKNDIEDKETVKEIIDKLVKKGKDGNRTKTFVKGMHSGMAFNIFDKIQQHDQEFDLKCQDLSSSKCLDMRTLHKNDTTSFKVSNENKDINNTNHHQKPVMPKLLDETSTIETIVEETFHKTKNKETNGKASPQNNQNFKNNIFSKTIKKAQIDNVRYDKFSKYSNSGKNKKYVKANEEMCKLISKLTGERAVTEQGNEEIQKLVTKLKNQTEETNSVSETSKDKKELLAATVKNSCCDNEKYVAERTCTYNEVPIHCNTSGNLKIVERQNEKPNNLKSLPLKQSTPLQLFNKAANGIEQDKCGNYKYNNKQEYSLICNKSGKVVSFEEHTEISQEIDSNNNISSEMEQKDEYLEKSSSDSVKACEGKQLLKKRQAVGQNYSMPTEKERIMHMLHYNTKLTGSVKNTQQMENIFKDMKPLSEIRQSTPNSLGVELGSGKIEDYDIHSIIRRLATDTEKFEVNNDQNRTNTLHQSCFLESNEAKELDVIKQNMGNLQDTNQVANIKNSTLENANDHISVLYFKNRSKFRHKQNSKENTIAGVLHDNDGIKAASTNTSLSVSFDPHEEGTDRLFNSVTSDESKNVQKEKEFPFTAPIMNIIAKLNKNSFDCPTRTDAVYSQNPLNSDVPRPFTEENKEAQSVQGSQTNALTNKEIMSLNKVPDPGCIGNNTFKKPKGNIEQKRLTKENNSNKHVEKNVVCLPIGGLAVRQKNAVVARDLYHKHVLTPNEKVPCDEKFIDRTKLDDGVDKLRQIQSKKHSEEIKHLIMENSSASLLDDPKTDVEKHEIHANDNFLKIFRRQTKILDNESLRVQNVTNVSSEHSVGTIDTVFADDQQKLVNKILFEISCGKSDEPTNCSSNILSPKKSNGDLRKDVKRQEINLERKNEIQSVTDVQSSRDVCKKSISIKTTEDEIVSSSMLLKTKRNIVQNEVKSGTNITEDQIINNVLLGTTCHELKSQPNTTILKDTFISSSHSVTNCEINVGSESCVHTQNSKPFNHPNQSSEDELSDKLWIKNSVFLKQRSDTSQLSQCLLNDQKDENNKIIENHDLSSHSIFEPESNLENPIQSCFHEKNRELLIRPKMNDDVNNNVTKNCDTRNSLLLSATKSSEANQTQITCIFDKNEQNNMMPKKTHISIKANELLADEEINRILTKNYEQCMRSKENNASQTRDDAISKLLKKTEDQKPKAKDIIKKYRKGKLKIYRLKKMKKPSKDLDKVEENLDFDDVFKKLTQDFQEPARCSSPCESLVSTPSSYKSVSTLRSETPTESKELSSFQRKLREGIELYYQLKDMINGQGVVDRAINLVSCLLNVGMWALNIIAQKGLIFGNLKIMLSSGETINCNVPDAYFILVVEKEAIFQKLLEEDIPNKLTRPFIMMTGKGFPDLNTQLFLRKLWIIMRIPVFILVDADPHGINIMLNYRFGSVANAHVSHHLAVPKARWLGLLPSEITMFNVKKQAMSTNEQKMVEKLLNTPYMKDNPGIVEELKILQKNNLKAGIEGLIKTDVFLSQVYLPHKFLHRDFI
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -