Basic Information

Gene Symbol
ZNF574
Assembly
GCA_942486075.2
Location
CALNXM020000363.1:652238-658390[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.024 1.2 10.0 1.8 2 23 268 290 267 290 0.90
2 19 7.4e-05 0.0036 17.9 1.6 1 23 323 346 323 346 0.96
3 19 6.1e-06 0.0003 21.3 1.2 1 23 355 377 355 377 0.98
4 19 0.0062 0.3 11.8 0.9 1 23 383 406 383 406 0.92
5 19 0.15 7.5 7.4 0.2 2 23 411 432 411 432 0.95
6 19 0.034 1.7 9.5 0.4 2 23 441 462 440 462 0.95
7 19 0.00021 0.01 16.5 0.5 1 23 468 491 468 491 0.96
8 19 3.6e-05 0.0018 18.9 0.6 1 23 497 519 497 519 0.99
9 19 0.00061 0.03 15.0 6.4 1 23 525 548 525 548 0.98
10 19 0.015 0.71 10.7 0.4 2 23 827 849 826 849 0.92
11 19 0.32 16 6.4 2.4 6 23 858 875 853 875 0.98
12 19 0.00023 0.011 16.3 3.1 1 23 881 904 881 904 0.98
13 19 6.7e-07 3.3e-05 24.3 1.4 1 23 911 933 911 933 0.98
14 19 9.4e-05 0.0046 17.5 0.1 1 23 940 963 940 963 0.97
15 19 0.028 1.4 9.8 0.5 2 23 968 989 968 989 0.96
16 19 0.00097 0.047 14.4 0.1 1 23 997 1020 997 1020 0.91
17 19 0.0028 0.14 12.9 0.1 1 23 1027 1050 1027 1050 0.95
18 19 2.3e-07 1.1e-05 25.8 2.8 1 23 1056 1078 1056 1078 0.98
19 19 0.00071 0.035 14.8 6.3 1 23 1084 1107 1084 1107 0.98

Sequence Information

Coding Sequence
ATGTCCGCAACAACTTTATGTCGGTTGTGTGTTTGTGCCCACACCGAATTTAAAAATCTATATAATGAACTTAACCAAGGAAATGAAATCTACGAAATTACTGTGAAATATTTTGATCCCATGTTTCTCAACTCCCATCAATATCCACAACTCTCAATGAGTATATGCATAAATTGTTGGCAGCACATTTATGACTTCCATAACTTCCAAAAGTCAGTTCTCAACGCTCAAATGGAATTTGAAAAAGATATTAAAGAAATTGTAACTGATATTAAAATGGAAAATGCTTTGTCAGCAGAAATAGAGCCTGTTGCTGATAATATACTATGTTTTAGCGAAAAAAATACTGATATTATAGCAGCTAAAAATGAAGATTCTAACTCATTCGATAGCATCATGGCAGATGATAACACCTTCACAATGGACTTAAAGGAGGTATTGCCCCAACAGATAAGAAAAAGGAGCAAACAGATTAAGAAACAAGATAAAGGAAAGTTGTCTGTAAAATGTGTAAGACAAGCAAGAAATATTGAAAAAAGAAAAGAGCCTCCGGAAAAATGTAGACCAAAATTAGAGAGAAAAGCACAGGTTAAAAACAAACAAAATGAGAATGAAAAGCTTACAAAGGATACTTCCAATTCTTCCAATTTATCATTAAACAATAATGACGATAATGAAAGCGACAACGATAATTATGCTGCAGATCCAGATGCATTTGTTTCTTCAAATGATAACCAAAAGTCAGTTAAAGAAAAGAGAAATGAAATTGATGCATTTATTGCACAATGGAAACCGTCATTGGAGTGTGATTTGTGCAATCATAATTTTAACAACCTTACATTGTTGCGAAAGCATTTTAGTTTAGAACATCCCCTGCTGAAATGTTACGTTTCCTGTTGTCAACGCAAATTAGTGCAACGTTTTAATATAGTTGAACATATTCGGTATCACATGGATTCAAATACATTCAAATGTAATGAATGTGAAAAGGTGTTTCTCACTAGCCGAAATTTAAATTATCACATGCGTGATCAACATACTGCCGAAGGACAAGAACGTAGCTTTGAGTGCTCCTTATGTCAAAAGCGTTTTTCTAAAAAAGGAGCACTAAAAACACATATCGAAACACATGACACCGATCAGACGTATAAATGCAGCCAATGTGATAAAGGATTTTCTACAGAGCAACGTCGAAAAATTCATGAGCGGGCAGTTCATAACGTTGATCGAGTGTGTGATCAATGTGGAAAGACGATACATGGTGGCGCAGCTCTTAAACAACATATGCTTGAACATGCTGGCGTTAAGAAACCAAAATGGCCATGTGATCAGTGTAATGCTGAACTGACTTCAAGATTTAGTTTAAAGCGTCACAAAACTATTCATGAATCATCGCAGGTTTATGCTTGCAATGAGTGCGGCAAAACTGCTTCTAGCCAAATGGGTTTGCATAGTCATATAAGGTATATCCATCAATTAGAGCGTAAATTTCAATGTACCATTTGTGAAAAGGCCTTTAAAGTTGCACATGTTTTACGCgaacatatggctacccacactggagaagatttatacaagtgcccgcactgtcctcagacatttaaggttaatgccaatatgcaccaccaccgcaaaaaaatacaccccatagaatgggcggagGGTAGAGCGAATAAAGTGTCTACAACTACCAATTTGAGAGATAAAATGTCTTTAAAATTATGTTGTTGTTTGTGTTGCACAGCATGCAGTGACTACAAAGCTTTACAAAATGATTGGGGGGAATGTAATGAAATCTATGAAATTACGGTCAAATATTTTGATCCGATGTTAATCACAGAATGCATGAATACAATAAGTTCTAGAGAGAGTAGGGTACTTTGTCTGGACTGTTGGGTACACATAAAGGACTTTCATGAATTTCATCTAACAGTACTAAAAACAAGGTCGTCACTAGAGCAGACCAATATTCAGAAATCACCGTTGCACATTAAACTAGAAGAAGAACAAGTCACTGTGCTATTGAATGATGAATACGTCGCTACTGCAGATGGAGAGTTGGTACAATTTAAAGATGATTCAGAATATGATCAGAATCCCATAGGAGACGATACTGAATTGGTTAGTGATGTTGATGATGATGAAGACGAAGACGAGTGCTACAAGAAACCTTTAAGCGAATTATTTAAAGCCCAAAAGTCTTTAAAAAGCAATAAAGAAAAAGACAATGAAAAACAGGATAAAGTAACCAATTTGTGTAATAATTTAGACAATAAAAGTAAACCAAAATCTCGTAGAGTTCGAAAGTCAAAAGAAACTGCAAAATTAGCTTCTGACAATGATGATAATGGTGATGAAACTCTAGCAATAAAAGAAAAGACAACGCCTAAAGACCCTGAAAATAATACTCGCCTTCATCCAGCCTTAGAAAAATTTCGAAAACATAATGAATTTATAGCGGAATGGAAATCACAACTAGAATGTGATGTTTGTAGTGAAATATTTTCCAATTTCGACTTGTTAAAGCTGCATTTTAAGGACAAACACAATGCAAGATGTTATGTCAAATGCTGTGAACGTACATTTTATCGTCGCTGTGCTTTGGTTGAACACATACGTCTCCATATTAATCCGGATTTGCATAAATGCGACATATGTGGTAAACTTAGTACCAGTAAATTCAATCTTAAACTTCATAAAAGAACTATTCACGAGGGAACACAACACACATTTGAATGCACTGTATGTCAAAAGATTTTTAAACAAAAACAAAATTTAGAACGTCATTTGTTAACGCATGTTACGGGCAATAAAGATTTTAAATGTAACGAATGTGACAAAGCATATGTTCTGGAAGTTCAACTTAAAGCTCACATTAAATTGGTCCATAATGATAATAGAGTTTGTGATCAGTGCGGTAAAACGCTGCACGGTATTGGAGCACTAAAAAAACACCTGAAAGAACATGAAGGTATTGAAAAGCCTAAATTTCCCTGTGACGAATGCGGTACGGAACTAGCATCGAGTACAAATCTAAAACGTCATAAAGCTGCATATCATAACGATGGTTCTACCGTGTACGTTTGCAGTATATGTGGAAAAGTCTCAGGTAGTGAACGCGGTCTAATGAACCATAGAAAATTTGTACACGAAATCGAAAGAAAACATAAATGCCCACATTGCGATAAGGGATTTAAAAGACCGAAAAATttacaagaacacattgccactcatacaggtgaagcgttgtatcagtgtcaagattgtccgaaaacctttaaaattaactccaaataccatcatcatcgtaaaacagctcaccctgttgagtgggaaaagGGCAGAAAGAATCGTTTGGAGAAACAAAAAATTGATTTTGAACAAGTTACAAATCAAGTTATACTTTAA
Protein Sequence
MSATTLCRLCVCAHTEFKNLYNELNQGNEIYEITVKYFDPMFLNSHQYPQLSMSICINCWQHIYDFHNFQKSVLNAQMEFEKDIKEIVTDIKMENALSAEIEPVADNILCFSEKNTDIIAAKNEDSNSFDSIMADDNTFTMDLKEVLPQQIRKRSKQIKKQDKGKLSVKCVRQARNIEKRKEPPEKCRPKLERKAQVKNKQNENEKLTKDTSNSSNLSLNNNDDNESDNDNYAADPDAFVSSNDNQKSVKEKRNEIDAFIAQWKPSLECDLCNHNFNNLTLLRKHFSLEHPLLKCYVSCCQRKLVQRFNIVEHIRYHMDSNTFKCNECEKVFLTSRNLNYHMRDQHTAEGQERSFECSLCQKRFSKKGALKTHIETHDTDQTYKCSQCDKGFSTEQRRKIHERAVHNVDRVCDQCGKTIHGGAALKQHMLEHAGVKKPKWPCDQCNAELTSRFSLKRHKTIHESSQVYACNECGKTASSQMGLHSHIRYIHQLERKFQCTICEKAFKVAHVLREHMATHTGEDLYKCPHCPQTFKVNANMHHHRKKIHPIEWAEGRANKVSTTTNLRDKMSLKLCCCLCCTACSDYKALQNDWGECNEIYEITVKYFDPMLITECMNTISSRESRVLCLDCWVHIKDFHEFHLTVLKTRSSLEQTNIQKSPLHIKLEEEQVTVLLNDEYVATADGELVQFKDDSEYDQNPIGDDTELVSDVDDDEDEDECYKKPLSELFKAQKSLKSNKEKDNEKQDKVTNLCNNLDNKSKPKSRRVRKSKETAKLASDNDDNGDETLAIKEKTTPKDPENNTRLHPALEKFRKHNEFIAEWKSQLECDVCSEIFSNFDLLKLHFKDKHNARCYVKCCERTFYRRCALVEHIRLHINPDLHKCDICGKLSTSKFNLKLHKRTIHEGTQHTFECTVCQKIFKQKQNLERHLLTHVTGNKDFKCNECDKAYVLEVQLKAHIKLVHNDNRVCDQCGKTLHGIGALKKHLKEHEGIEKPKFPCDECGTELASSTNLKRHKAAYHNDGSTVYVCSICGKVSGSERGLMNHRKFVHEIERKHKCPHCDKGFKRPKNLQEHIATHTGEALYQCQDCPKTFKINSKYHHHRKTAHPVEWEKGRKNRLEKQKIDFEQVTNQVIL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-