Basic Information

Gene Symbol
Clamp
Assembly
GCA_951812925.1
Location
OX638369.1:109580431-109586139[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 1.6e-05 0.0019 19.8 2.6 1 23 135 157 135 157 0.99
2 7 1.2e-05 0.0014 20.2 1.0 1 23 460 482 460 482 0.98
3 7 2.6e-05 0.0031 19.1 0.0 1 23 488 510 488 510 0.99
4 7 4.8e-06 0.00058 21.4 3.2 1 23 516 538 516 538 0.99
5 7 2.8e-06 0.00033 22.2 0.4 1 23 544 566 544 566 0.98
6 7 2.4e-06 0.00028 22.4 0.4 1 23 572 594 572 594 0.98
7 7 0.00014 0.016 16.8 0.2 1 23 600 622 600 622 0.96

Sequence Information

Coding Sequence
ATGGAAGACTtaactaaaaatataatttttaccaCAAATGCCATTGGTGCCAATGGACAACCCACAACTATACAGTATCAAACAGCTGATGGAACCATATTGAAACAACCTAAAATTGAAGGTCAAAAGACAGATCAACCAACATTTTAttatacaacaacaaatGGTAATACTGCTGTAAATTTAGCGCAGTTAACAACAGATGATAACAAAACCTGCTATATAGCGCAACCAGTAGGTGGATATAACTATGCGCTTGTTAATGGTATGCAATTAAATCAAGGTGGTGCCATAGGTATTGCAACATTGGATGCGCAGGGACGTTTACAAATtattaatcaaaataaaccaattACAACGACTATTGcccaaaatatgcaaaataccATTTCGAATATCAGTTTCAAATGTGATGTTTGTGGACTAATGTTTTCACACTTGGCGCTTCTTAATCATCACAAGCGAATTCATGCCCAGGAAGGCACTGATCAGCAACAAACTGGACAGGCCGATTCAATTGCTGTTGTCAATGCACAAGGTCTTGTGCAAACACAAAATATAATTACAGAAAATGGACAAATGGGTCAAATACAAATTGTTGCTACTGAAGCACTGGAACCAGCAAATACACAACAGCAACATACTGTTAtgcagcaccaacaacaaccccaacaacaacagcagcagcaacaacaacaacaacaacaacaacagcagcagcagcagcaacaacaacaacaacagcagcagcaacaacaacaacaacagcatcagcaacaacaacaacaaaccacTAGCAATGAAGTTATCACCACAACAGTTGGAAAAGTCCATAAACTTGAACATTCGAAATGTTCTTCATGTGGCAATCCAATGTTACACGCTTCCACCAATAAAcgaaaaggtccaaaagttgtACGTTGTGAACAATGTGTACAGGCCGATCAGGCGGCACAACAAGCAGTTGCCGCTGCTCAACAAGTAACTCCGACACAAATTTTTGTAGCACCCGATGGAGagataaaatttgaaatgaacGAAATGCCAAGTGGCACCTCTGACTCATCAATGGATTCGTTGACAGCGCAGAATATCATTCCTGGTCATTTACATCCTGTGCAAATAATATCAACAACACCACAGGCACAACAACAATTACAGAGTTTGGTATCCCAACAGACACAACAGAATCAATCATCGCCAGTAAAGCGTGAATTGTGTACAGCAGCTGGTCATCATCCGGTTAAGAAACGTAATACCCAACAGGTAACCAAGTGTCAGAAGTGTAATGGTTCTGGTGTCATTTATGTTGGTAGCGGAGGACCGGGACATAGTAATAAGAATGCAGCGAATATAAAACAAGAAACACCGAAACCTTTTACGTGCAATATTTGCGGCGGTACATTTTCGCGTTATTCCAGTTTATGGTCACATAAAAAGCTACACAGCGgtgagaaaaattacaaatgtgCAATATGTGGATTAGCTTTCGCCAAGGCTGTTTATTTAAAGAACCATGCAAGGATACATACGGGTGAAAAGCCCTACAAATGCCAAACATGCGGTATGCAATTCTCGCAATCACCACATCTGAAAAATCACGAGCGCACTCATAGCGGTGAACGTCCTTACGTTTGTGAGGTATGTGACAAAGGATTTGCACGTCATGCCACACTTTGGAATCATCGACGCATACACACCGGTGAGAAACCCTATAAATGTGACATTTGTGGTTCAGCATTTTCCCAAGCTGCGCATCTAAAGAATCATGCCAAAGTACATTCTGGTGAAAAACCATTTAAATGCGATATTTGCTCAGCGGCATTTGCAGATCGTTTTGCATTAAAACGACATCGTGGTATACATCAGAAATATGGTCAAACGGCACCGCGGCAACCTGCACAGACGCCACAACAGCAGAGTCAAGCACAAACAATGAATACCGATGGTCAGTCTGTTATTATACATAAACAAGAAATGCCAGAGATGGATGATGATGCTCAGCATGAAGTTGTCATTTCAGGTTTATAG
Protein Sequence
MEDLTKNIIFTTNAIGANGQPTTIQYQTADGTILKQPKIEGQKTDQPTFYYTTTNGNTAVNLAQLTTDDNKTCYIAQPVGGYNYALVNGMQLNQGGAIGIATLDAQGRLQIINQNKPITTTIAQNMQNTISNISFKCDVCGLMFSHLALLNHHKRIHAQEGTDQQQTGQADSIAVVNAQGLVQTQNIITENGQMGQIQIVATEALEPANTQQQHTVMQHQQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQTTSNEVITTTVGKVHKLEHSKCSSCGNPMLHASTNKRKGPKVVRCEQCVQADQAAQQAVAAAQQVTPTQIFVAPDGEIKFEMNEMPSGTSDSSMDSLTAQNIIPGHLHPVQIISTTPQAQQQLQSLVSQQTQQNQSSPVKRELCTAAGHHPVKKRNTQQVTKCQKCNGSGVIYVGSGGPGHSNKNAANIKQETPKPFTCNICGGTFSRYSSLWSHKKLHSGEKNYKCAICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVCEVCDKGFARHATLWNHRRIHTGEKPYKCDICGSAFSQAAHLKNHAKVHSGEKPFKCDICSAAFADRFALKRHRGIHQKYGQTAPRQPAQTPQQQSQAQTMNTDGQSVIIHKQEMPEMDDDAQHEVVISGL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00352036;
80% Identity
-