Basic Information

Gene Symbol
lola
Assembly
GCA_031763695.1
Location
JARPRI010000006.1:350739-357600[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.00084 0.058 13.9 4.1 1 22 27 48 27 48 0.95
2 13 2.7 1.9e+02 2.9 0.9 1 11 56 66 56 70 0.83
3 13 0.0042 0.29 11.7 7.2 1 20 91 110 91 111 0.93
4 13 0.023 1.6 9.4 2.4 1 23 120 143 120 143 0.91
5 13 6.7e-05 0.0047 17.4 0.1 1 20 207 226 207 228 0.95
6 13 0.00077 0.054 14.0 1.4 1 21 251 271 251 272 0.95
7 13 0.6 41 4.9 0.3 1 13 280 292 280 293 0.90
8 13 0.017 1.2 9.8 1.7 1 21 344 364 344 365 0.95
9 13 0.016 1.1 9.9 0.6 1 23 376 399 376 399 0.96
10 13 7.1 4.9e+02 1.6 8.2 1 23 406 429 406 429 0.97
11 13 0.0068 0.47 11.1 0.1 1 21 578 598 578 599 0.96
12 13 0.56 39 5.0 0.1 1 19 666 684 666 687 0.78
13 13 0.0074 0.51 10.9 0.6 1 21 697 717 697 721 0.91

Sequence Information

Coding Sequence
atgctGATTTCAGACTCCACAGATGGAGCCACTGAAAGCGGGACGAAGTGCACAAGAAAAGCGCGCGGTCAAGGCtactttttttgcaataaatgCGGAAGGCGATATCATCAGGAAAAAACACTGAAGAGACATCTGAGAAAAGAGTGCGGAAGAGAACCGACTTTTCAATGCTCCTATTGTCCCTATAAATCTACGTATAACATTGATGCGCACTACGGGTCGCTCGGGAACTTCATCTGCGTCCAGACGACAGACGACCAACAGAAACACGCTTGCAGCGCCTGCGGGAAAACTTACAAACACAAACACCATTTGAAAAGGCATCACGACTTTGAGTGCGGAATCGATCCTAAGTTCAAGTGTGCATTTTGTCCTCACAAAACAAGATACAAGAACAGCTTGATGAAGCATATTGTCGCGCGACATCACAAGCTCTGGGGTGTCGCGTCGCAGTTTGAAAACAgtCAACATTACAGTCCGGCCAATTGGACCGTGGCCACCTTGCCATCGACCTCTCGCGAGGATCATTATTTTCGTCAGCTTCGTTCGATGAGTAAGGACGGATCCTTATCGGATAaggagaaatcgaaaaaacgCGGTTGGGGCCCACGAAAATATCGTTGCGCGGATTGCGGCAGGACTTTTGCTCTTGCCGCGTCCTTGACACGTCACAGGTCCTTGGAGTGCAGCGGACAGTCGTCTCGGACGTCGAAGAGAAACGAATCCTTAGTCAAGAAATCAAAAGATCACGAGTGCAACAGATGCGATCGTtcctataaatttttgacttCATTATGGCGTCATCAGAATTTGGAATGCGGCGTGGAGCCGAAATTTGCATGTCCAGTCTGCCACGTTAGGTTTGCTCAGAAAAAGATTCACGGATGGAACGTCAGAGGATACCTGCACAACTACGGCTCAATGGAAAACGCCGAAGGATCCGTTCAGGCGTTAGGCAGTATGGAAATAGGAGATTTCAAACACCTGGATAATAAATCGATAACATTTGAGCCCAGCTACAAAAGACACGTCTGTAGCTACTGCAAGAAAGTCTACCTGCTCAAGAACCTCCTGAAACGGCACATGCAATATTCCTGCGAGATGATACCGAAAAGTGCACAATTCGCGTGCACTTTCTGCCCCTACAAAAGCATGTACAAAGCAAACATGGAAAGACACGTGAGAAACGTCCACGACGCCGGTGCGATGAAATTCCACTGTGAGCTCTGTAACTTTCGCAGCAACTACACATTCTGCGTCCGTCGTCACATGAAAACCTTCCACAACCGTCCTGGTCGTACAAAGCCATGTTCGGATTCGATGCCAGCAACGTTATTATCCAGCGGAACTCGACGCGTGTCAATTGCGACGTCCGAGGACGGACGTTTCAGTGCACGGACTGTGGGAAGTCTTATGCGGTTCAAAGGTCACTCTGGAGACATCGTAAATTCGAATGCATCAATTCACGGCCTAAATTCACCTGCGAGCTGTGCCCGTACAAGAGCTCGCACAAGTGAGTTCCCTGTCGAGAATTTCGAAGACGAGGACGAGTGCCTGACGaatgacgaggaggaggaggagcagcTGTCTAAGGAAAGTTTTGTGAAAGTCATCAAAACCCCGATAACGAACGTCAAGGGAATTTCGGAATTATTCGAAGTATCGAAGGAGggtgaaattatattaaagtctaatgaaaatcatattcTCACCCTGAAGGATCCGACCTACGAGTGCGAGTCCTGCGGGAAAACTTACGCCTGGGCTACGTCCTTGAGCAGACACCGTAGGGAATGTcaagagaggaagaaattaCGTAAGCAAACCGAAGAGATTAAAAGCGACGAAGAAATCATAAGAGATTCAATAGAGAATCCAGGCTCTTCGATATCGTCACCTCGCGAAGACGAAGAAACGGTCCAGGAAGATGCTGTGGCCAAGTACAAGCCACGATTTCGCGAATTGCAAAAATACGTATCGAAAGACGGCGTGTACTCGTGTTGGGACTGCGGCAAGTACTATCTGTGGGCATCTTCTTTGTCCAGGCACAGGACCATCGAGTGCGGAcctaaaaataagaaaagattcGTCTGCAATCTTTGCAACTATCGTACAGGATACAAAGGAAATTTTGTGAGACACCTAAAAGCACCAAGGCACATAATGCACAGCAGTttggaaaagaagagaatgcAAATTGCTacaatgaagaagaagaagaagaacatcAGCGAGGAGGCTGACGAAGAGTTAGAAGAGACAGCTTAA
Protein Sequence
MLISDSTDGATESGTKCTRKARGQGYFFCNKCGRRYHQEKTLKRHLRKECGREPTFQCSYCPYKSTYNIDAHYGSLGNFICVQTTDDQQKHACSACGKTYKHKHHLKRHHDFECGIDPKFKCAFCPHKTRYKNSLMKHIVARHHKLWGVASQFENSQHYSPANWTVATLPSTSREDHYFRQLRSMSKDGSLSDKEKSKKRGWGPRKYRCADCGRTFALAASLTRHRSLECSGQSSRTSKRNESLVKKSKDHECNRCDRSYKFLTSLWRHQNLECGVEPKFACPVCHVRFAQKKIHGWNVRGYLHNYGSMENAEGSVQALGSMEIGDFKHLDNKSITFEPSYKRHVCSYCKKVYLLKNLLKRHMQYSCEMIPKSAQFACTFCPYKSMYKANMERHVRNVHDAGAMKFHCELCNFRSNYTFCVRRHMKTFHNRPGRTKPCSDSMPATLLSSGTRRVSIATSEDGRFSARTVGSLMRFKGHSGDIVNSNASIHGLNSPASCARTRARTSEFPVENFEDEDECLTNDEEEEEQLSKESFVKVIKTPITNVKGISELFEVSKEGEIILKSNENHILTLKDPTYECESCGKTYAWATSLSRHRRECQERKKLRKQTEEIKSDEEIIRDSIENPGSSISSPREDEETVQEDAVAKYKPRFRELQKYVSKDGVYSCWDCGKYYLWASSLSRHRTIECGPKNKKRFVCNLCNYRTGYKGNFVRHLKAPRHIMHSSLEKKRMQIATMKKKKKNISEEADEELEETA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00294024;
90% Identity
iTF_00297864;
80% Identity
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