Basic Information

Gene Symbol
-
Assembly
GCA_954871355.1
Location
OX940889.1:25453039-25466156[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 28 2 2.9e+02 3.6 1.0 2 19 207 224 206 226 0.81
2 28 0.00049 0.071 15.0 0.5 2 21 255 274 254 275 0.93
3 28 0.0001 0.014 17.2 0.4 2 23 306 328 306 328 0.97
4 28 0.0011 0.16 13.9 1.4 1 23 389 412 389 412 0.96
5 28 0.005 0.73 11.8 0.2 1 23 426 448 426 448 0.96
6 28 0.0039 0.56 12.2 2.8 2 23 507 528 506 528 0.95
7 28 0.00012 0.017 16.9 3.3 2 23 569 591 568 591 0.97
8 28 6.1e-06 0.00089 21.0 1.3 1 23 641 664 641 664 0.97
9 28 0.0014 0.2 13.6 0.1 1 23 727 749 727 749 0.97
10 28 0.001 0.15 14.0 7.0 1 23 760 782 760 782 0.99
11 28 0.033 4.7 9.3 1.7 2 23 794 815 793 815 0.96
12 28 0.0035 0.51 12.3 1.0 1 23 825 847 825 847 0.98
13 28 0.011 1.6 10.8 5.0 1 23 874 896 874 896 0.96
14 28 0.0031 0.44 12.5 4.6 1 23 907 929 907 929 0.97
15 28 5.8e-05 0.0084 17.9 0.4 1 23 937 959 937 959 0.98
16 28 0.00036 0.053 15.4 0.6 2 23 979 1001 978 1001 0.97
17 28 0.32 46 6.2 0.2 1 23 1019 1041 1019 1041 0.93
18 28 0.12 18 7.4 3.4 1 23 1048 1070 1048 1070 0.97
19 28 0.02 2.9 9.9 1.0 2 23 1081 1103 1080 1103 0.95
20 28 0.0059 0.85 11.6 0.2 2 23 1126 1147 1125 1147 0.95
21 28 0.059 8.6 8.4 0.1 2 23 1228 1249 1227 1249 0.94
22 28 0.016 2.3 10.2 3.8 3 23 1257 1277 1255 1277 0.96
23 28 0.016 2.3 10.2 0.9 2 23 1288 1310 1287 1310 0.95
24 28 0.73 1.1e+02 5.0 0.4 2 11 1327 1336 1327 1345 0.86
25 28 1 1.4e+02 4.6 2.3 2 21 1349 1368 1348 1369 0.93
26 28 0.46 66 5.6 1.9 2 23 1417 1438 1416 1438 0.93
27 28 0.0062 0.9 11.5 0.6 2 23 1449 1471 1448 1471 0.96
28 28 0.87 1.3e+02 4.8 2.5 2 21 1509 1528 1509 1529 0.94

Sequence Information

Coding Sequence
ATGGCCCTCAAACTCGGGAAATGCAGGCTGTGTCTCAAGCTCGGCGACTTTTACTCCATCTTCACGGTGGACAATGCCATCCAACTATCGGAAATGGTTATGGAATGCTCAAGGATAAAGGTATATGAAGGAGATGGACTACCAGACAAGGTATGCTCAGAATGCATACAGAAGCTCAGCAGCGCATACATATTTAAGCAACAATGTGAGAGAGCAGACCAGGAGCTGCGCCGGAACTATGTGCCGCCTCCAGGGTTTAGCATCAGTCCACCACCACCTAATAGACAAAGCAGCGATTCGGCATTTTCAACCCACACCGACAGCTCCAACCTGAAGTCATCTTTCATCGAAAGCAAAGTGACGCCCGTGAATAGAAGCAGGAAACGCAGCGTCGAGAGCGACAATGCGTCCGAGGCGAGCCGGTCGCACAGCTACAGCCGGCCCGGCAGCTCCAAGCGCGTGGAGGAGCTGCGCCGCTCGCAGAAACGGGCGCGTCTCTCCGGGAACAACTCCAACAACTCGCAGTGCGACTCCGACTACGACAACGGCGGCTCCAGCTACGTGCCCGACACCGACCTCGAAGACTCCGACGAGCCGCTCGTCAAGCCGAACGAGATCAAGTGCGACGTCTGCTTCAAAACGTTCAAATGGGACAAGAGCCTCAAGTACCACAAGAGCCACGTCGATTGCAGGAAGAAGGCCACGCCCGCGAGCACGCCCAAGACGCCCGTCACCGAGCCCGACGACGACGACGAGGGGATGAGCTGCAACGTGTGCAATAAGAGCTTCAAGCTGAAGATCATGCTGAAGCGGCACCTGGAGACGTGCGGCAAGAAGCCGGCGATCACCCCGCAGAAGGAGATAGTGATCGCGCTGGAGCCGATCGACGCCGTGCACAAGACCGTTAAGAAGCCCACGTGCGAGTACTGCACCGCCAAGTTCAAGACGGTGGAGAATCTCGAGAAACATCTGAGGGTGATCCACGCCGCGGTGCTCAAAAAGGAGCTGAAGGACACGAAGGTTACACCGAGCGCGTCTCCGAAGGCGCGGGAGAGCTCGGGCGGGGTCTCCGTGCCGTGCGTGTTTTGCTCGAAGCCGTGCGAGGACTACCAGGCGCACAGCACGCACTTCAACCTGTGCCCGAAGCGAGACGCGCGCTACACGTTCGAGTGTCAACTGTGCGGGAAGGTGTCGAGCCGGAAGAACAGCTACTTCCTCCACCTGAAGAACATGCATTTCGAGCCGCGCGGCAGCAAGCCGGCCGAAGGCGGCAGCTTCGAGTGTCGGATCTGCAGCAAGAAGCTGTCGTCGCAGGAGGCGCTGGTGTCGCACCTGACAGCGCACGCCGCCGCGGGCAGGGACGACGCAGAGGAGGACAACGACGCCGGGGACGACTACCACGACGCGGACGATGACCCCACGCCAGAGGAGGACGTCGAGGACTCCAGGGCTAGCACGATCGGCGAAAATAATTCAGTGACGTCGTCGAACCGCACGCCCGTGCCCGGCGCTCCGCTACATTGCCGAGTGTGCGACAAGGAGTTCAAATATCGGAAGTCACTAATCACCCACGAGTTGAAACACACGGACGACGAAATTAGAGTGAAGAATGAACCGCCCGAGCTGCGCAACCAGAGCCTGCTCAGCGAGGCCAACAGATACTCCGACATGGAGTCCAGCCAAGACGAAGAGAGCGATGACCTCACTTGCGATATATGCGAGAAGATGTTCTCCTACAAGCGTCTCCTGATACATCATAAGCGGACCAAACACAACATGTCATCGGGCACGAAACGAGCGAAAATAAACCTTAAAGACTGCTCCGTAAGGTGCTTGCTATGCGACATAGAGATGAAAGTGAGCGACATTAACGAGCACAACCAGAAGCATATTTCGATGAACATCAAGCCGAGAAATATCTACACTTGTGCGGAGTGCGGGCAGAAGTTCAAGAGCTGCAGCAATTTGGCGAACCATATTAAGCTTGTTCATAGGTTGAAGCAGCAGAAGGACAAGGTGCCGCGTCAGTTCCTGGGCGCGGACCTGGCGGATTTTTGTGAGGTCGTTGTGACGAAAGCGGAACCGCTGGAAGATATCCAGAGTCACAACGGCTTTGGCGAGGTTCCCCCACAACAGAAGTCGGGTAAGGCGGGCGCTCCTACGGTGGACCTGAGTGGGTTCACATGCCCCATCTGTGGCAAGAAGATGGGCACGCTCATCTCTCTGAAGCGGCACGTCAACTGGCACTCATACGTGGGCGCCAACCTTGAGAAGAAGTACGAGTGCTTCGTTTGTAAAGAGAGCTTCAAGTTCCAGTGCCACTTCAAGATCCACATGCGGGTTCACTACAACGACACCAACCTCGACGCGTCATTCCTCACGTGCACCATCTGCAACCGTCGCAGCAAACATCTCCGCGCCGCACAGGCCCACATGAACTATCACAAGCAGACCCGCTTCCAGAACAAAGACTACCAGTGCTCCATCTGCAAACGTGTCTTCCAGTACAGGAAGGTATATCTCTCCCACATGGCCATACATTACAAAAAGGGAGAGAGCGCCATGAACACCGTCGTCGGCGATAAAATTCCAGCCTCGAAGAACACCTTTGAAGGCACACACTCGTGTCATCTGTGCGGAAAAGCTTGCGAGTCCGAAGTGTCCCTGAAACATCATCTGATCTGGCACAAGTCGAAGACTTTACTGTACGGCGCGCGGCACGAGTGCCAGATGTGCCAGCTTCAGTTCACCAATAAGAGACACTTGGAGCTCCACACGAGAGCTCATTATGAGGACGAGAACGGCCCTTACAAGTGCAGCGTCTGCGGCAAAGGATACATAGACGAGGAGTACATGAGACGGCATCAGAAGGGACACAACTTCGACCACCAGTCGCACAAGAAGCGGCTCGAGAAACTGCGCAAGGACAAAGTGAAGTGTCCCATCTGTTCGCGGTACTACCCGGATTTGATTCACTTGATCCGACATCTGCGGCGGACGCACCCGGAGAGCAAGATGATCAAAGAGGACCCGGACGCGCCGCCGCCGGCGTACTACTCCTGCAAGCTGTGCGCCAAGGTGTTCCTCGATCCGATCCGGCTGAAGAAACACGAGGAGGCCCACCTGAGGAAGCCGAACTTCTTCAAATGCAAGTTTTGCGGAAAGAAAACGATTTCTCTGAAGAATCACAACATTCACATCAAGGGGCACCTCACGAAGAAGCACATCGATAACCCGCTCAAGTGTACCCAGTGCGACGAAGTGTTCGTCCTGGGATACGCGCTGCATCATCACCTGAGAGACGTGCACGGGATCACAGAGACGTGGATAGCGGAGCGCGCGGACGAGGCGCTGGTGGGGCCGCTCAAAGACCTGCAGTGCTCCGTGTGTCTGAAAGTGCTCGCCAGCAAGGGGAACTTCGAGCGGCATCTCGACTATCACAACACGCTGCGCTGCAACTACTGCAACGACTACTTCAGCGGGCTGCGCTTCCTCGAGGGACACCTCGCCTTCAGCTGCGAGAAGAAGCGCCTCGTGGGAGACACGGAGGTCCATCCTCGACGGATCAAATGCGAGCTGTGCTACAAGCCGTTCCACTTGCAAGTCAAGCTGGACTGTCATCTGCGAACGCAGCACAACATCAAGGTCGACAAGCAAGCGAGCACCGGCCAGACTGAGACGGTTTGCGGCTACTGCTTCAAAGTGTTTGAGAACGAGTTCGCTTTGGCGGGACATAAACTGTACCACCGCAGCGTTGGATACTTCGGGTGTCTCTACTGTCCTCGCAAGTTCAACACGCAGACTGCGTACCGGAAGCACAAGAACCATCACTTCGCTCAACTGAATGTGGACGAGCCCACCAAGTGCGAGCACTGCGATGAAACCTTTGTCGCCTTCAGGGAGATGATATACCACATGAGAGACGAACATAATGATGACAAGGACTGGCTCGTGATGCCCAAAGACGCGATAGAAGAGAAGTGTCCCATCTGCGAGAAGACATTCTTCAACATACCGCGCCACCTGCAGTACCACGAGGAGAACAAGTGCAAGAAGTGTAACGAGTACTTCTTCTCCCGCGTGGACTTCGACAACCACCTGTGCGCCATAGAGAGCGACGCGGAGGACGCGCCCTACGCCGACCCGGCCGGCCAGCCCTACCAGGAGTGCACCTTCTGCTTCAAGCCCATCACCAAAAAAGACTCCAAGAAGAAGCACGACATGTTGCACAAAACGTCGGGCGCGATCTCGTGCCGGTTCTGCCATCTAAAGTTCAAGACCATCGACGCGTTTAATATCCACGCGTTCTCGCACCGCAGCCGCAAGTACGTGAAGAAGCCGATCAAATGCCGCGAGTGCAAGGAGCGCTTCGTGAAGTACGGGCCGTTCATCAAACACATGAAAAGCGCTCACAAGTCGACCAAGAAGGTTCACTACCGAGCGGTAGTGCGGGCGGAGCGCTGCGTCGTCTGCGGCGGAGACTTCCCAAACCTTCACAACCACTACCGGGCGCACCTcgccaaccgctgccagcgcTGCCTCAAGTACTTCGTCTCCTCGAAGCTGTTCGCTCGCCACCAGTGCGACAAGGAAGACGAGGACCCCTCGAAGGTGTTCACCTCGGACGAGAACCTGACGGCGTTGATAAACTCGTACGTGCCTCGCGATGAGAAGGACGACGAGAAGTTCTACGGGTATACTGACGACGAGGACGAGACGGAGTTCCCGGCGCGGGACTCCGGGCAGGTCGTGAAGACTTACTCGAAGCCGGTGAAAATGGCGAAGCCGCCGAAGTTGTCGGTTCCTCCGCAGCTGCCGTCCGCGCCGATAGACTTGCAGCAGGCCGACGACGAGAGGAATCTTCATATGATGGTGCAATCTCCTATTATATCCGACGTCCTCTCGCTGTATCAGAAGGTAGACCCCGACAGCAAGAATCAGATGTCGGAGTTTGGTGAGATCGTCAATCTGACGGACGACGATTCCCTGGACGCGATCGATGTGAACGCACCCGTGGTTATCATCGATGACTCTAGTTAA
Protein Sequence
MALKLGKCRLCLKLGDFYSIFTVDNAIQLSEMVMECSRIKVYEGDGLPDKVCSECIQKLSSAYIFKQQCERADQELRRNYVPPPGFSISPPPPNRQSSDSAFSTHTDSSNLKSSFIESKVTPVNRSRKRSVESDNASEASRSHSYSRPGSSKRVEELRRSQKRARLSGNNSNNSQCDSDYDNGGSSYVPDTDLEDSDEPLVKPNEIKCDVCFKTFKWDKSLKYHKSHVDCRKKATPASTPKTPVTEPDDDDEGMSCNVCNKSFKLKIMLKRHLETCGKKPAITPQKEIVIALEPIDAVHKTVKKPTCEYCTAKFKTVENLEKHLRVIHAAVLKKELKDTKVTPSASPKARESSGGVSVPCVFCSKPCEDYQAHSTHFNLCPKRDARYTFECQLCGKVSSRKNSYFLHLKNMHFEPRGSKPAEGGSFECRICSKKLSSQEALVSHLTAHAAAGRDDAEEDNDAGDDYHDADDDPTPEEDVEDSRASTIGENNSVTSSNRTPVPGAPLHCRVCDKEFKYRKSLITHELKHTDDEIRVKNEPPELRNQSLLSEANRYSDMESSQDEESDDLTCDICEKMFSYKRLLIHHKRTKHNMSSGTKRAKINLKDCSVRCLLCDIEMKVSDINEHNQKHISMNIKPRNIYTCAECGQKFKSCSNLANHIKLVHRLKQQKDKVPRQFLGADLADFCEVVVTKAEPLEDIQSHNGFGEVPPQQKSGKAGAPTVDLSGFTCPICGKKMGTLISLKRHVNWHSYVGANLEKKYECFVCKESFKFQCHFKIHMRVHYNDTNLDASFLTCTICNRRSKHLRAAQAHMNYHKQTRFQNKDYQCSICKRVFQYRKVYLSHMAIHYKKGESAMNTVVGDKIPASKNTFEGTHSCHLCGKACESEVSLKHHLIWHKSKTLLYGARHECQMCQLQFTNKRHLELHTRAHYEDENGPYKCSVCGKGYIDEEYMRRHQKGHNFDHQSHKKRLEKLRKDKVKCPICSRYYPDLIHLIRHLRRTHPESKMIKEDPDAPPPAYYSCKLCAKVFLDPIRLKKHEEAHLRKPNFFKCKFCGKKTISLKNHNIHIKGHLTKKHIDNPLKCTQCDEVFVLGYALHHHLRDVHGITETWIAERADEALVGPLKDLQCSVCLKVLASKGNFERHLDYHNTLRCNYCNDYFSGLRFLEGHLAFSCEKKRLVGDTEVHPRRIKCELCYKPFHLQVKLDCHLRTQHNIKVDKQASTGQTETVCGYCFKVFENEFALAGHKLYHRSVGYFGCLYCPRKFNTQTAYRKHKNHHFAQLNVDEPTKCEHCDETFVAFREMIYHMRDEHNDDKDWLVMPKDAIEEKCPICEKTFFNIPRHLQYHEENKCKKCNEYFFSRVDFDNHLCAIESDAEDAPYADPAGQPYQECTFCFKPITKKDSKKKHDMLHKTSGAISCRFCHLKFKTIDAFNIHAFSHRSRKYVKKPIKCRECKERFVKYGPFIKHMKSAHKSTKKVHYRAVVRAERCVVCGGDFPNLHNHYRAHLANRCQRCLKYFVSSKLFARHQCDKEDEDPSKVFTSDENLTALINSYVPRDEKDDEKFYGYTDDEDETEFPARDSGQVVKTYSKPVKMAKPPKLSVPPQLPSAPIDLQQADDERNLHMMVQSPIISDVLSLYQKVDPDSKNQMSEFGEIVNLTDDDSLDAIDVNAPVVIIDDSS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-