Basic Information

Gene Symbol
ZFY
Assembly
GCA_949316355.1
Location
OX438536.1:4703462-4707061[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 6.2e-06 0.00047 20.6 0.1 1 23 35 57 35 57 0.98
2 19 2.1e-07 1.6e-05 25.3 0.8 1 22 63 84 63 84 0.97
3 19 0.26 20 6.1 0.7 2 23 91 113 90 113 0.95
4 19 3.3e-05 0.0025 18.3 4.5 1 23 120 143 120 143 0.96
5 19 2.2e-05 0.0017 18.9 2.5 1 23 149 172 149 172 0.96
6 19 7e-06 0.00052 20.5 2.9 1 23 178 201 178 201 0.98
7 19 3e-05 0.0023 18.5 0.5 1 23 206 228 206 228 0.98
8 19 0.0031 0.23 12.2 2.3 1 23 237 259 237 260 0.95
9 19 0.89 66 4.4 1.4 3 23 268 285 266 285 0.83
10 19 2.5e-06 0.00019 21.9 3.1 1 23 291 313 291 313 0.98
11 19 2.9e-05 0.0022 18.5 0.3 1 23 319 341 319 341 0.98
12 19 6.3 4.7e+02 1.7 0.4 1 9 347 355 347 359 0.89
13 19 0.11 8.4 7.2 1.7 1 19 379 397 379 402 0.87
14 19 6e-05 0.0045 17.5 2.7 1 23 406 429 406 429 0.96
15 19 2.1e-05 0.0015 19.0 2.5 1 23 463 485 463 485 0.95
16 19 0.01 0.75 10.5 1.6 1 23 494 516 494 516 0.91
17 19 2e-06 0.00015 22.2 2.3 1 23 547 569 547 569 0.98
18 19 5.2e-07 3.9e-05 24.0 3.9 1 23 575 597 575 597 0.99
19 19 0.002 0.15 12.7 1.8 1 20 603 622 603 624 0.94

Sequence Information

Coding Sequence
ATGCGGGAACATTCTGATTGGAATGGTACGGCCTGTGTATACTGCGGCAAGTTAGTTAAAGagatgaaaaatcatttgagAACTCATACTGGCGAAAAACCGTATCCATGTCCAGAATGTGAGAAGTCTTTTGCTACTCTCGatgccaaaaaaaatcatttgaggGTGCACACCAAAGAGAGGCCTTATACATGCAAAATTTGTAGTAAGAGCTTCACGCAGAGTAGTACCTTGGTGGTACACATGAGAAAAAGCTCAAAACCAGAAGTCCCTTGCACCGTATGTTCTAAGTTATATCGTTCTAAGAAGATCATGGAAGAGCACAGACGTATGAGGCACAACATAGTACAAGGAGATCACACATGCGACATATGTGGAAAGACCTTCTCTAAAAGGAAATCTCTTCATTCACATGTGAGCAAAGTGCACATCAACAGAAACAAACACAAATGCGATCTTTGCGACAAAGGATTTTCGATGCCATCCCATCTTCAAGAGCACAAACTCAGGGTTCATGAAAATGTTTATAGATACTCATGCGATGTCTGTAAGAAAGGTTTCAGCCACCCAAAGGAACTGAACAATCATAAAAAGACTCAGCATGAAGGTGTAAGATTCGAATGTACTGACTGTGGGAAGATTTATAAAACACAGAGTATCTATAACCAGCACATAGCTACTCACGACGAAGACTTTTCTCAGGAAAAACATCGTTGCGACCAATGTGAAGCAGTCCTCACCACAAGGAGGGGTTTGATGAAGCACATTGAACGCCATCACTCTGGATGGACTGGAACTCCATGCAACTACTGTGGGAAATTGGTGAAAGAGCTGGAAGCACATTTGAGGATCCATACCGGGGAAAAGCCTTACCAATGTACTTTCTGCGGCAGGTGTTTCGCAAGTCGGGGGTCTCTGAGAACCCACCAAATGCTTCATACGAAAGAAAAGAGGTACTCTTGTGGAGTGTGCCAAAAAGCGTTCACCCAGCGCACACCCATGGTGGTCCACATGAGGTCTCATACAGGAGAACGGCCATACCAGTGTGAGTTCTGTTCGAAGAGgttatttgatatttattcgCCTTCCATCGAAGAAATCAAGAAGGCTTTAttcaacaaatacaaaaaactgTTTACTTGTGAGCTCTGTAAAGAGTCATTCACGCAGGAATTAAAGTTGGGACAACATTGTGTTCGGGAACACGGTATTCGATTTCAGTGCAGCATATGCGATAAGACGTTTGCATATAAGCATTACGTTTCGAGACATGAACAGAGTGAGCATTTCAAAAACTTTACATATCATTGCAAACCTTGCGACAAAGGCTTTTGGTGCGAGAGTAAACTTAAAAAGCATAACGCGGTTCAACATGATGGAAAGAGGTTTTTATGTGAGATCTGTAGCAAAACCTTTAAGAGTGAGGAACATTTCAAGATTCATTTAAAAGTTCACGACGAGTCGTTCAAGCGTGAAGAGTATAAGTGCGAAGAATGCGGTAAGGTTTATACTGCCATCCAGTCTTTCAACTTCCACAAACGTAAACATGCCGGCAACATCGCAAGTATTTGCAATGTGTGTGGAAAGAAGGTGACGTGCATCTCAAAACATATGCGGCTGCACACTGGAGAAAAGCCCTACAGTTGCGAATTTTGTACAAAGACCTTTACAGACTACAGCGGTTTAAAAAATCATAGACGGGTACACACCAGGGAAAAACCATACAAATGCACGGAATGTGACAAATGCTTCACCCAAGCAAACACTTTGAGAATACACCTACGTTATCACAGAGACGAGAGGCCCTTCCAATGTGATATTTGTTCCAAGAAATACGTTACCAAAACGCTCCTGAAAGGACATAAATGTGGCGGACCTCCAAAGGGCAAGACTTGA
Protein Sequence
MREHSDWNGTACVYCGKLVKEMKNHLRTHTGEKPYPCPECEKSFATLDAKKNHLRVHTKERPYTCKICSKSFTQSSTLVVHMRKSSKPEVPCTVCSKLYRSKKIMEEHRRMRHNIVQGDHTCDICGKTFSKRKSLHSHVSKVHINRNKHKCDLCDKGFSMPSHLQEHKLRVHENVYRYSCDVCKKGFSHPKELNNHKKTQHEGVRFECTDCGKIYKTQSIYNQHIATHDEDFSQEKHRCDQCEAVLTTRRGLMKHIERHHSGWTGTPCNYCGKLVKELEAHLRIHTGEKPYQCTFCGRCFASRGSLRTHQMLHTKEKRYSCGVCQKAFTQRTPMVVHMRSHTGERPYQCEFCSKRLFDIYSPSIEEIKKALFNKYKKLFTCELCKESFTQELKLGQHCVREHGIRFQCSICDKTFAYKHYVSRHEQSEHFKNFTYHCKPCDKGFWCESKLKKHNAVQHDGKRFLCEICSKTFKSEEHFKIHLKVHDESFKREEYKCEECGKVYTAIQSFNFHKRKHAGNIASICNVCGKKVTCISKHMRLHTGEKPYSCEFCTKTFTDYSGLKNHRRVHTREKPYKCTECDKCFTQANTLRIHLRYHRDERPFQCDICSKKYVTKTLLKGHKCGGPPKGKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
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80% Identity
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