Basic Information

Gene Symbol
ZFX
Assembly
GCA_951806755.1
Location
OX638256.1:2446750-2448129[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 1.3e-06 0.00011 23.0 1.2 2 23 145 166 144 166 0.98
2 11 6.9e-06 0.00055 20.7 2.3 1 23 172 195 172 195 0.97
3 11 1.2e-06 0.0001 23.0 0.4 1 23 204 226 204 226 0.98
4 11 0.0003 0.024 15.6 0.3 1 23 232 254 232 254 0.97
5 11 0.0073 0.59 11.2 8.2 1 23 260 282 260 282 0.94
6 11 9.9e-06 0.00079 20.2 1.1 1 23 288 310 288 310 0.98
7 11 2.4e-06 0.00019 22.1 1.6 1 23 316 339 316 339 0.96
8 11 1.4 1.1e+02 4.0 0.1 5 20 345 360 343 363 0.87
9 11 0.0033 0.27 12.3 0.2 2 23 370 392 369 392 0.94
10 11 2.7 2.2e+02 3.1 0.1 1 16 398 415 398 423 0.82
11 11 1.8e-05 0.0015 19.4 1.2 1 23 429 452 429 452 0.92

Sequence Information

Coding Sequence
atgaACAAAAATAATTGCCGTCTATGTCTCGAAAACCCTGGTGTTGTGTCGATTTATAGTAGTAATGAAAATCAAATTAACGCAAAAATATCGTATTGTTGCGTGAATATTAGTATTGAAGAAAACGATGGTCTACCATCACACATTTGTAACTTTTGTGAATGTCAACTTACAActtgttatgattttttaattaagtgtgaagagacagacaaaaaattgcgtttaattaaatttaataactcTGACGAAGAATGcaatacaaaaattgaaataaaaacagaaatagACGAAAACTCCATTTCAGATGATGCTAATGAGAACTCATATGAATCACCTAATGAAGTTAAGCAAGAAATCGATTGGAAAGatgtattaaagaaaaaatatcgaagttataagaaaagaaaaagtaaaatttcaagCATAACCAAATGTACTATATGTGGTAGAAAATGTGCAAATCCTTCTACCCTTGCTATACATATGAGATCTCATACAAATGAAAGGCCATATTCTTGTCAATCCTGTGATAAAACCTATAAAGATAGTGGGAGCCTCAAACGACACACACAGAGAAATCATTTCAGAGATAAACGGGAGAGAAAGTTTATTTGTGAGAATTGTGGAAAAGgctttttttcaaaaagtgAAGTTAAAATACACATGCGTATACATACTGGAGAAACACCATATGCTTGTTCAGCTTGTCCTGCCAGATTTACTCAAATAAGTACCTTGCAAAGACATACGCTTAGACACACCGGTGAACGAACTCATATATGCCTAACATGTCACAAAAAATTTTGTACCAAAGATGAATTACGATCACATTTCACAGTGCATTCAActgtaaaaaagtttatatgtcCAATATGTAAggcactttttaaatataagaataatttaagaaaacatGTTAGAAGCCATTCAGAAGGTGATAAGTTCATTTGCAATCACTGTGGTCGTAATTTTAGTATGAAAGGTAATTTAAAGATGCATATAGAGAGATTGCACTCATCAAAATCAGGATATTGCAATATATGTTTAAAGAATGTGTCAAATATTGAGGCTCATATGTGGAAACATACTGGTGAGAGGCCCCTAAAATGTGAATATTGTGCAAATAGTTTTGCTGAACAAAATGCTTTGGCTCggcatattaattttaaacataaaaaaacagatAGATACAAATGTACAGTGGATGGTTGTTCTGTTATGTTTCCATCAAGGCCAATGTTAGATTTTCATGTGGCAAAACTACATGGAACAGTAAAACCATTTCAATGCGATAAATGTTCCAGAGGCTTCTATAGGAAAAGTGATTTAGCTAGACATAAGATAGGTACACATAAAGAGAAACTCCTATTGGATTGA
Protein Sequence
MNKNNCRLCLENPGVVSIYSSNENQINAKISYCCVNISIEENDGLPSHICNFCECQLTTCYDFLIKCEETDKKLRLIKFNNSDEECNTKIEIKTEIDENSISDDANENSYESPNEVKQEIDWKDVLKKKYRSYKKRKSKISSITKCTICGRKCANPSTLAIHMRSHTNERPYSCQSCDKTYKDSGSLKRHTQRNHFRDKRERKFICENCGKGFFSKSEVKIHMRIHTGETPYACSACPARFTQISTLQRHTLRHTGERTHICLTCHKKFCTKDELRSHFTVHSTVKKFICPICKALFKYKNNLRKHVRSHSEGDKFICNHCGRNFSMKGNLKMHIERLHSSKSGYCNICLKNVSNIEAHMWKHTGERPLKCEYCANSFAEQNALARHINFKHKKTDRYKCTVDGCSVMFPSRPMLDFHVAKLHGTVKPFQCDKCSRGFYRKSDLARHKIGTHKEKLLLD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00160068;
90% Identity
iTF_00247433;
80% Identity
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