Basic Information

Gene Symbol
ZEB2
Assembly
GCA_947093115.1
Location
OX352473.1:4180025-4194757[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.00017 0.013 16.3 1.5 1 23 250 273 250 273 0.98
2 11 0.022 1.6 9.7 3.7 1 23 280 302 280 302 0.97
3 11 8 6.1e+02 1.6 0.2 1 9 306 314 306 325 0.77
4 11 0.13 9.9 7.2 0.5 3 23 335 356 333 356 0.94
5 11 0.00012 0.0088 16.8 0.6 3 23 361 382 359 382 0.94
6 11 0.0023 0.18 12.7 5.9 1 23 385 407 385 408 0.94
7 11 0.16 12 6.9 2.0 2 22 417 437 416 441 0.91
8 11 0.0037 0.28 12.1 3.1 2 23 448 470 447 470 0.94
9 11 1.8 1.4e+02 3.6 1.3 1 23 476 499 476 499 0.84
10 11 1.1e-05 0.00083 20.1 1.2 3 23 510 530 509 530 0.98
11 11 4.1e-05 0.0031 18.3 0.6 1 23 536 559 536 559 0.96

Sequence Information

Coding Sequence
ATGGCGAAATCAAAATTAGAAAGTTGTTATGGATGCTTATCTGTAGACAGACTGTTATTACCAATCGATAATTACTTGAAAATTTACATTAAAATAATGGAAGACGAAATACGAAATATTAGTATTCTGACTTCTACGGATATTCCAAAAATGTGTTGGGAATGTCGAGCTATGCTTCGTAATATAGTTAAATTTCAAGAAAGAATTAAAGCAGCTTATAAATATTTTACTAGTGGTAAAAGCACGCGCCGCATAAATTTACTTTCCGGTTTGTCATACTCGTACACAGACCAATATATATCCGCACAACACGAAGATGACAGTAGAGAAGACTTAAAAGATATAAAATATGATGAGCTTATAGCTGATATACAAACTGACAACGTTAGTGTTAAAGAAGAAGAATTATCGGATAGCAAATATGACGAAATCGATGATGTTAAACATATTAATTATGACGTAGAAATCAAAACAGAGATCGAAACCGCTGTTAAAGAAGAGTGTAACTTAGAATTTATTGAAAATGAATTTGATTTAAATGTTATAAAAAAAGAATGGCAGAAGAACAAAAGGAAAATGATATCAGAAAAAATAAAAAAAGCAATGAGCGCCAAATATAAAATAATTTTTAAAGATGATAATAGTATTAATTTTACGCGTCATTTTAAAAAGGTCTCAATAGATGATAAAGAAAGATTGTATTGGTCAGCAATGGATAAGAATGTAAGAAATTTTAGGACTATGGCATATACATGTAATTTGTGTACTACAGGATATGCCAAGAGCGAATATTATGCGAAGCATATGAGAACATTTCACTCGAAGACAAGCGGAAATTTTGAATGTGACATATGCAAAAGGAAGTATAAATGCAAGTCAAGATTGAAAAGTCATATAATAGAACACTTTTCAAAATATGTCTGCACAATTTGCAAATTCGAAACGTACAAATTGTGGACAATTAATGGCCATTTGGATTGTGCTCATAGAAGGGCGGTTATGTGCTTATCTTGTGGATTGAAATTTGAGAAACGTCCAGAGTTCTATGATCATTATAAGAAAATGCATTCTAAAGTGATCTGTGATACTTGTGGAAAGAAATATACAAAAAAACAAAGCCTCATCCAACATATAGTCAAACGTCATTCCAAACATAGATGTCATATTTGTAAGCGTGATTATTCATCACTCGACGCGTTAACACGTCACAATAATCTCCATCACGTTATATCACGCACAGAACATTGTTACTGCGTTGAATGTGACATACAATTCGATAATATGTCGAGGTATACTACTCATTTGAAAACTAGTATTAAGCATAAACCGATTGTAGGAATACCATGTCCAGAATGTAACAAAGTGTATAATAAGAAATGCACAATGAATAACCATTACAATCATGTACATTTGCGAAAGACGAAGTTTTACTGTGATAAATGTAAAAGGTACTTCCTCAATGGCTTCCGTCTCAGACAACACGTAGCTTCCGTACATGATAAAATACCACAGGAAAAAAATAAAATATGTCCGCATTGTGGTCGAGGGTTTTCGACAAATCGCATTTTAACCAATCACATACGAACTCATACTGGGGAAAGACCTTACAGTTGTGAAATATGTCAATCTACTTTCACCCAAAAAACAGCTCTCAAAGTGCACAAACGTGCTATACATAAAATAAAAGATTAA
Protein Sequence
MAKSKLESCYGCLSVDRLLLPIDNYLKIYIKIMEDEIRNISILTSTDIPKMCWECRAMLRNIVKFQERIKAAYKYFTSGKSTRRINLLSGLSYSYTDQYISAQHEDDSREDLKDIKYDELIADIQTDNVSVKEEELSDSKYDEIDDVKHINYDVEIKTEIETAVKEECNLEFIENEFDLNVIKKEWQKNKRKMISEKIKKAMSAKYKIIFKDDNSINFTRHFKKVSIDDKERLYWSAMDKNVRNFRTMAYTCNLCTTGYAKSEYYAKHMRTFHSKTSGNFECDICKRKYKCKSRLKSHIIEHFSKYVCTICKFETYKLWTINGHLDCAHRRAVMCLSCGLKFEKRPEFYDHYKKMHSKVICDTCGKKYTKKQSLIQHIVKRHSKHRCHICKRDYSSLDALTRHNNLHHVISRTEHCYCVECDIQFDNMSRYTTHLKTSIKHKPIVGIPCPECNKVYNKKCTMNNHYNHVHLRKTKFYCDKCKRYFLNGFRLRQHVASVHDKIPQEKNKICPHCGRGFSTNRILTNHIRTHTGERPYSCEICQSTFTQKTALKVHKRAIHKIKD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00248453;
90% Identity
iTF_00248453;
80% Identity
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