Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.35 18 5.9 1.9 1 23 25 48 25 48 0.94

2 7 0.059 3 8.3 0.3 2 23 63 83 63 83 0.92

3 7 0.00042 0.021 15.1 0.7 1 23 89 112 89 112 0.98

4 7 1.3e-05 0.00064 19.9 0.1 2 23 128 150 127 150 0.95

5 7 0.00015 0.0077 16.5 0.7 1 23 184 206 184 206 0.98

6 7 0.00087 0.044 14.1 2.2 1 23 212 234 212 234 0.98

7 7 4.8 2.4e+02 2.3 4.0 1 19 240 258 240 264 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.35	18	5.9	1.9	1	23	25	48	25	48	0.94
2	7	0.059	3	8.3	0.3	2	23	63	83	63	83	0.92
3	7	0.00042	0.021	15.1	0.7	1	23	89	112	89	112	0.98
4	7	1.3e-05	0.00064	19.9	0.1	2	23	128	150	127	150	0.95
5	7	0.00015	0.0077	16.5	0.7	1	23	184	206	184	206	0.98
6	7	0.00087	0.044	14.1	2.2	1	23	212	234	212	234	0.98
7	7	4.8	2.4e+02	2.3	4.0	1	19	240	258	240	264	0.89

Coding Sequence: ATGCAAACCATTCATGAGTCAGTCCCTGATCAATCCCAGACCGTCGGCCACGACAAagacaacagaaaaaaatatatttgcgaTTCCTGTGGATTGACATTATTTTCACGATCGGGCATCCACAGCCACATCCTACACAAACATTTAGGTCTACAGACATCAGCCGGTGCCCAGAACAAAACTGAAGTCTGTACTGTTTGTGGAGTGTATGTAACGAAGAGAAACTTCAAAGACCATGTCAATTCTCACTCATCAGCCAAGGACTATAAATGCGAATTTTGCGGATCAGCCGTAAAAtCGGTCTTCACGTTAAGGAAACACATCAAGAGGGTTCACATGAAAAGCAAGTCATCGACACTACCAGCAACTATCCAAAAAGTTGAGtgtgaaatttgtgagaaaCAATTTTCCAGCCCTGAAGGACTACGACGTCATGAACTGCGATACCACAGCGACAACGAAAACATTAGATGCGAAGTCTGCGGCAAAAAATCGCTTACATTTGCTGAACATAATTAccatatgaaaatccattcgtTGGAGCGGAAATATCAATGTGAATCATGTGAACTTCGATTTGCCCGGTACGAGGGTCTGAAAAATCATCGTATCAAACATAAAGGCGAGTGGTCGTACAAATGTGGATTATGTGCGAAGATATTTAAGCATTCGTCGTCCGTATCGGGTCATCGAAAATCGCACAAGGTGAACGGTTACTATCATTGTGGATGTTGTGACGATCGTTTCAAAGACTATGCTCAgctgaaaaatcattttgttaatTCGAGTCACAGTTTTTATTCTAAAGTTAAGCGACAAactgaataa
Protein Sequence: MQTIHESVPDQSQTVGHDKDNRKKYICDSCGLTLFSRSGIHSHILHKHLGLQTSAGAQNKTEVCTVCGVYVTKRNFKDHVNSHSSAKDYKCEFCGSAVKSVFTLRKHIKRVHMKSKSSTLPATIQKVECEICEKQFSSPEGLRRHELRYHSDNENIRCEVCGKKSLTFAEHNYHMKIHSLERKYQCESCELRFARYEGLKNHRIKHKGEWSYKCGLCAKIFKHSSSVSGHRKSHKVNGYYHCGCCDDRFKDYAQLKNHFVNSSHSFYSKVKRQTE

Sequence clustering based on sequence similarity using MMseqs2