Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00086 0.049 15.0 4.1 1 23 120 143 120 143 0.95

2 6 1.8e-05 0.001 20.3 1.3 1 23 147 170 147 170 0.95

3 6 7.4e-07 4.2e-05 24.7 0.7 1 20 175 194 175 197 0.94

4 6 6.3e-08 3.6e-06 28.0 1.3 1 23 203 225 203 225 0.98

5 6 0.00027 0.015 16.6 2.7 2 23 232 253 231 253 0.98

6 6 4.7e-06 0.00027 22.1 1.1 1 23 259 282 259 282 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00086	0.049	15.0	4.1	1	23	120	143	120	143	0.95
2	6	1.8e-05	0.001	20.3	1.3	1	23	147	170	147	170	0.95
3	6	7.4e-07	4.2e-05	24.7	0.7	1	20	175	194	175	197	0.94
4	6	6.3e-08	3.6e-06	28.0	1.3	1	23	203	225	203	225	0.98
5	6	0.00027	0.015	16.6	2.7	2	23	232	253	231	253	0.98
6	6	4.7e-06	0.00027	22.1	1.1	1	23	259	282	259	282	0.96

Coding Sequence: ATGCAATTAAGAATTAACTCAATTCAAAACATATTTAGAGGATATTGTGAAAAACTAATACCTGTAGAGAATAATGTTGAGGAAAATTATGATACTTATGGTGAAAATGAAATCCAATATGTCGAAGATAAAGTAAGTGTTTACGAAGCAATGGAATACACAGAAATAGTTGATGAACAAGATACAGACACTGACCAATTTGATTTGGCAGTAAGGCAAGAAATATTTTCAGaggataattataaaattaaaactgaaattCAAGAAGAATATCAGAACGACATGGAAAATAATTCACAGATTAAAATAGAAATCAGGAATCTCAGTAAAATAGGAAAACCAAAAAGAGTATATAACTATAATTGCAAAGTGTGCTCTGACCACTTTTCAAGCCAATCGgattttaataaacatatgaAGGACAAACACAACATCGGGCATGTGTGCAATTGGTGTGGAAAAGAGTTTTCCAGTAGTGGAAGTCTTCACACTCATGAAGCTACTCTCCATTCAAATATTGTATTTCAGTGCAATATTTGCGATAAAACATTTACTCAAAAAGGAAGTCTGGCTAAACATTATCCTATTCATACAGgtGAAAAACGATTTCAGTGTGAAGAATGCGGGAAGAAATTTATTCACAGATCTTCGCTAACAGCTCACATCCTATCACACACTGATATAAAGCCAGTCCAATGTGAAATATGTTTCATGAGGCTGCGGAACCGTTCGCACTTGGGCAGGCACATGAAAAGGCACACGGGAGAAAAGAATCACGTATGCTCTGCCTGCGGAAAAATGTTTGcggaaaattataatttgaaaatacATATGAAAATGAAACATGGACAATGTCAATGA
Protein Sequence: MQLRINSIQNIFRGYCEKLIPVENNVEENYDTYGENEIQYVEDKVSVYEAMEYTEIVDEQDTDTDQFDLAVRQEIFSEDNYKIKTEIQEEYQNDMENNSQIKIEIRNLSKIGKPKRVYNYNCKVCSDHFSSQSDFNKHMKDKHNIGHVCNWCGKEFSSSGSLHTHEATLHSNIVFQCNICDKTFTQKGSLAKHYPIHTGEKRFQCEECGKKFIHRSSLTAHILSHTDIKPVQCEICFMRLRNRSHLGRHMKRHTGEKNHVCSACGKMFAENYNLKIHMKMKHGQCQ

Sequence clustering based on sequence similarity using MMseqs2