Basic Information

Insect: Brachyptera risi
Gene Symbol: topi
Assembly: GCA_964007535.1
Location: OZ023338.1:36206-41608[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 2.4e-05 0.0021 19.5 0.1 2 23 83 104 83 104 0.98

2 13 1.8e-06 0.00016 23.0 0.2 2 23 121 142 120 142 0.96

3 13 9.2e-06 0.00081 20.8 0.5 1 23 148 172 148 172 0.97

4 13 1.7e-06 0.00015 23.1 4.0 1 23 180 203 180 203 0.96

5 13 1.2e-07 1.1e-05 26.7 0.3 1 23 210 232 210 232 0.98

6 13 0.0014 0.12 13.9 0.5 2 23 272 294 271 294 0.96

7 13 5.2e-08 4.6e-06 27.9 0.6 1 23 300 322 300 322 0.97

8 13 2.4e-06 0.00021 22.6 3.2 1 23 328 350 328 350 0.98

9 13 5.8e-07 5.1e-05 24.6 5.0 1 23 356 378 356 378 0.99

10 13 0.00011 0.0098 17.4 3.7 1 23 384 406 384 406 0.98

11 13 9.1e-07 8.1e-05 23.9 3.3 3 23 416 436 415 436 0.98

12 13 0.0004 0.036 15.6 1.2 1 23 442 464 442 464 0.97

13 13 7.8e-06 0.00069 21.0 0.7 1 23 470 492 470 493 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	2.4e-05	0.0021	19.5	0.1	2	23	83	104	83	104	0.98
2	13	1.8e-06	0.00016	23.0	0.2	2	23	121	142	120	142	0.96
3	13	9.2e-06	0.00081	20.8	0.5	1	23	148	172	148	172	0.97
4	13	1.7e-06	0.00015	23.1	4.0	1	23	180	203	180	203	0.96
5	13	1.2e-07	1.1e-05	26.7	0.3	1	23	210	232	210	232	0.98
6	13	0.0014	0.12	13.9	0.5	2	23	272	294	271	294	0.96
7	13	5.2e-08	4.6e-06	27.9	0.6	1	23	300	322	300	322	0.97
8	13	2.4e-06	0.00021	22.6	3.2	1	23	328	350	328	350	0.98
9	13	5.8e-07	5.1e-05	24.6	5.0	1	23	356	378	356	378	0.99
10	13	0.00011	0.0098	17.4	3.7	1	23	384	406	384	406	0.98
11	13	9.1e-07	8.1e-05	23.9	3.3	3	23	416	436	415	436	0.98
12	13	0.0004	0.036	15.6	1.2	1	23	442	464	442	464	0.97
13	13	7.8e-06	0.00069	21.0	0.7	1	23	470	492	470	493	0.96

Sequence Information

Coding Sequence: ATGAAGGAGGGCGAAGGCAAAGACGCGGAGCAAGAAGCCGAAGAGAGCCCCGACTGCGACCCTCTGGAGAACGTCGAGTGTCGCTACGAGGCCCCGGCCGTCGTACCCAGCACGTCCAGCGAAACCGACGCGAAACCTCCAAGCTCGCGTCCCAACAAGCGCAAGTGCAACATCCCCATCCGCCGCCTCTCCAGCCCTCCCAGCCCCAAGTCCCGGATAAACACTCGCAGCCGGGAAAAGTGCGCCAAGTGCGTGGAGTGCGACGGGACGTTTGCTTCGCCCGCCTCGCTCAAGATCCACATGAAGACCCACAAGCTGGTCAAGGTCAAGGTGAAAGTCCCCAGGGCCCCGCTGGAGCTGGTGTGCAAGGCGTGCGGCAAGGTGTTCTCGCGAGCGTTCGCCCTGAAGAACCACCTGCGGATCCACACGGGAGAACGTCCGTACATCTGCACGTGGCAGGACTGCAACAAGGCGTTCCGCTTCGAGACCAACCTGAAGAACCACATCATCACGCACCAGCCGACGGAAGAGCGGCCGTTCAAGTGCAAGGAGTGCGACAAGTGCTTCACGCGGGCCAACACGCTCAAGCGGCACAACATGATGGCGCACACGGACGAGCCGCACCCGTACCCGTGCGAGGACTGTGACAAGTCTTTCATCGACACGCGCGCGCTCAAGAGGCACATGGAGACTCACGCCAAGCACGCGCAGCAGCCGCTGTCGTTGGCTGACGGCATGCTTCCCTCCAGCATGCTCAAGCCGCTGCGGTCCCGGGGGGCCAGGGGGGGCAAGAAGGTCCCCCCGCAGCCCATACCCTGTCCCGAGTGCGACCGCACCTTCCTCTATCCGCGCTTTCTCAAGGACCACTACCGGCGGAAACATTCCACGGAGAGACCGTTTGTCTGCGACATTTGCGGCAAGAGCTTCATAACGTCGTCCTACCTGAAGCGCCACACGATATCTCACTCGGAAGAGAAGCCTTTCCGCTGCTATTACTGCGACAAGACCTTCACCTCGTCCGGCAGCCTCAAGTACCACATCTTCACGCACACGGGGGAGCGACCCTACCAGTGCAGCGATTGCGGCAAGTGCTTCACGCAGGCCTGCAGCCTCAAGTCGCACATGGTCACGCACAGCTCCGAGCGCGACCACCAGTGCCACGTCTGCCAGAAGCGCTTTGCCGGCGCCAACTACCTGAAGACCCACCTGAAGATCCACCTGGCCGTGCGAGAACGCCCCTCCCTGTGCCACCTCTGCGACAAGACGTTCACCACGAACAGCGCCCTCAAGAAGCACCTCCAGATGCACACCGGCCAGCGCCTCTTCCAGTGTTCCGTCTGCTTCAAGGACTTCACCACCAAGggcattctcaagcgacacctGCTGCTGCACACGGGCGAGCAGCTCTACAGGTGTGCCGAGTGCGACAAGGGCTTTGTGGAGGCTAACAAGTTGAGGAACCACATGATAACGCACCACAGCAGCAAGCCCTTGCAGCTCACCATGGGCCACAGGATGGATTAG
Protein Sequence: MKEGEGKDAEQEAEESPDCDPLENVECRYEAPAVVPSTSSETDAKPPSSRPNKRKCNIPIRRLSSPPSPKSRINTRSREKCAKCVECDGTFASPASLKIHMKTHKLVKVKVKVPRAPLELVCKACGKVFSRAFALKNHLRIHTGERPYICTWQDCNKAFRFETNLKNHIITHQPTEERPFKCKECDKCFTRANTLKRHNMMAHTDEPHPYPCEDCDKSFIDTRALKRHMETHAKHAQQPLSLADGMLPSSMLKPLRSRGARGGKKVPPQPIPCPECDRTFLYPRFLKDHYRRKHSTERPFVCDICGKSFITSSYLKRHTISHSEEKPFRCYYCDKTFTSSGSLKYHIFTHTGERPYQCSDCGKCFTQACSLKSHMVTHSSERDHQCHVCQKRFAGANYLKTHLKIHLAVRERPSLCHLCDKTFTTNSALKKHLQMHTGQRLFQCSVCFKDFTTKGILKRHLLLHTGEQLYRCAECDKGFVEANKLRNHMITHHSSKPLQLTMGHRMD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00242441;
90% Identity: iTF_00242441;
80% Identity: -