Basic Information

Insect: Brachypalpus laphriformis
Gene Symbol: topi_1
Assembly: GCA_945910015.1
Location: CAMDTZ010000910.1:20585-21521[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.12 48 6.6 6.0 1 23 74 96 74 96 0.95

2 8 9.6e-05 0.038 16.3 0.5 1 23 102 126 102 126 0.97

3 8 0.027 11 8.6 9.2 1 23 132 155 132 155 0.97

4 8 6.9e-05 0.027 16.8 0.6 1 23 161 183 161 183 0.98

5 8 9.4e-06 0.0037 19.5 0.9 1 23 189 211 189 211 0.97

6 8 6.7e-07 0.00027 23.1 0.2 1 23 217 239 217 239 0.98

7 8 0.00028 0.11 14.9 4.8 2 23 246 267 245 267 0.97

8 8 1.9e-07 7.6e-05 24.8 0.3 1 23 272 294 272 294 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.12	48	6.6	6.0	1	23	74	96	74	96	0.95
2	8	9.6e-05	0.038	16.3	0.5	1	23	102	126	102	126	0.97
3	8	0.027	11	8.6	9.2	1	23	132	155	132	155	0.97
4	8	6.9e-05	0.027	16.8	0.6	1	23	161	183	161	183	0.98
5	8	9.4e-06	0.0037	19.5	0.9	1	23	189	211	189	211	0.97
6	8	6.7e-07	0.00027	23.1	0.2	1	23	217	239	217	239	0.98
7	8	0.00028	0.11	14.9	4.8	2	23	246	267	245	267	0.97
8	8	1.9e-07	7.6e-05	24.8	0.3	1	23	272	294	272	294	0.98

Sequence Information

Coding Sequence: ATGTGTAGGGTTTGTAGTTTTGGCTTAATGCCTACGAAATTTAGAAAAAAAAAATATCTAAGCCAGGAAACGGATTCAATTGGAATGAACACACCCAATCAACTTACCGAGGAAAACAACACTCAAGTGGAACTCTTAATCGAAACTGTTTTTCCATCCAATGACAATGATGGATTCTCCAATGAAGATGTCATAAACGTAGTCAACGGAAAAAAAATATATGAGTGTGGCTATTGCCATAAACAATTCCAGAGCAAGTGCAGTAGTGAAAATCATCGATCAATACACGAAGGCACTATTGAGTTCAAATGCCCCGAGGAGTCATGTTCAAAAGTGTTTCGTATAAAGAAATTGCTCTCTAAGCATATGGTCATACATCGTAAAGTAAAACCACATAAATGCGAGTTTTGTTCGCATAGATCCAACTACAAATCCAACCTCAGGGAACATGTTCGACGGTGTCATACTTTAGAGAAACCATTTAAATGTCAATATTGTGAGAAGCCGTTCGTTTCTGCTACGGAAAAGCAAATGCACGAACGTGTACACACCGGCGAAAAGCCATTCGTATGTGAATTGTGTGGAAAAGAATTCAAATCCACAGCAACGTTAAATTACCATCTATATAAGCATAATGGGGTTAAAAAATATTCATGCACGCTCTGCGATAAGGCATTCTCTAGTCCCAGTCTTTTGTGGGAGCATAGTCTTACTCATTCTAAAGATAAAAAAATTACTTGCGACGTTTGTGGACAGAAGTGTAAACATGCCAAAAGTCTTCGACAGCACAAGCGATTGCATGAGGATAAACGGTATGTTTGTAAGGTTTGCCAAAAAGCGTTTGCGCAAAATTCAGGCTTATATATCCATATGAAGTCGCACAAATTTGACTAA
Protein Sequence: MCRVCSFGLMPTKFRKKKYLSQETDSIGMNTPNQLTEENNTQVELLIETVFPSNDNDGFSNEDVINVVNGKKIYECGYCHKQFQSKCSSENHRSIHEGTIEFKCPEESCSKVFRIKKLLSKHMVIHRKVKPHKCEFCSHRSNYKSNLREHVRRCHTLEKPFKCQYCEKPFVSATEKQMHERVHTGEKPFVCELCGKEFKSTATLNYHLYKHNGVKKYSCTLCDKAFSSPSLLWEHSLTHSKDKKITCDVCGQKCKHAKSLRQHKRLHEDKRYVCKVCQKAFAQNSGLYIHMKSHKFD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -