Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.23 13 7.9 0.5 1 23 155 179 155 179 0.95

2 6 0.014 0.74 11.8 0.5 3 23 208 231 207 231 0.86

3 6 1.2e-06 6.4e-05 24.5 0.4 1 23 236 258 236 258 0.95

4 6 1.8e-05 0.00097 20.8 3.5 1 23 264 286 264 287 0.95

5 6 0.0028 0.15 13.9 3.4 1 23 292 314 292 314 0.97

6 6 1.5e-05 0.00082 21.1 1.6 1 23 320 342 320 342 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.23	13	7.9	0.5	1	23	155	179	155	179	0.95
2	6	0.014	0.74	11.8	0.5	3	23	208	231	207	231	0.86
3	6	1.2e-06	6.4e-05	24.5	0.4	1	23	236	258	236	258	0.95
4	6	1.8e-05	0.00097	20.8	3.5	1	23	264	286	264	287	0.95
5	6	0.0028	0.15	13.9	3.4	1	23	292	314	292	314	0.97
6	6	1.5e-05	0.00082	21.1	1.6	1	23	320	342	320	342	0.98

Coding Sequence: ATGTTATCCGATGACACATTATGCCAACAAATTTCAGTATGCACGGGAATTAATATCAGAGATGATACAAGAAGTGAGAAGCTTCCAAAGTTTGTTTGTAGTTCATGCAAAAATAATATCGATCAGTTCATTACATTTCAAGAAAATTGTGTGAAAATAGATGAAAAATTGAAGATACttttagaaaaaaACTTTCTAAATGTAAGTGAGTCTACGCAATTATCTATTGATAGTATTAAAATAGACGCCTCATTAGAAAATGTCTGGGAACATACTGAACTAGAAGACATCGAATTAAATAAGTTTATAAATGACTCAGAACAAGTAGAAGAAAAAGATGGCGTGAACATTGAAAATGACTTTTTCGATACGGCTTACTATAATCAAGATTTCGACAgcgaaaattctgaaaaatactCCACCGTCGAAGAAAAAAAGAACGATTCGAAAAAGAGTGCGGTATATGTTTGCCCGGTTTCGAACTgtggaaaaaaaatgatatctaAATGTGGGTATGTAAAACATTTAGAAGGTCATGATGCTGATTACAATCCAGACCTTGACAACGCAAGTGATGATGACAGAAGGCCACGTGGAGCACGAAGGCCACTACGTAATGTTTGTCGTTTTATGAACTGTGGTAAAAGATTTGCTTCAAGAGCTGCATATAAACAACATGTATATAATATGCATGATATCAAGGAATTTTTGTGCCCGACTTGTGgtaaATCGTTTAGAAGATACAGTGCATTAAAAGTTCATGAACAAATACATTTACCACACAAAGAATTTGTGTGTACGGAATGTAATATGGAATTCTCTCAACACGCAAATTTAAAAACGCACATCAAATTACATCATGAAGGTCACAGATTCTACTGCACCAAATGCGGTAAAGGTTTTCTAACAAATTGTACACTAAAACGGCACGAACTCATCCATACAGGCGTTAAAGATTTCAAATGTGATACGTGCCCTGCTGCATTCTATACTCGACGTGAATTAACGAAACACCAGCGGTATCATAATGTAAGTGCAAGATAA
Protein Sequence: MLSDDTLCQQISVCTGINIRDDTRSEKLPKFVCSSCKNNIDQFITFQENCVKIDEKLKILLEKNFLNVSESTQLSIDSIKIDASLENVWEHTELEDIELNKFINDSEQVEEKDGVNIENDFFDTAYYNQDFDSENSEKYSTVEEKKNDSKKSAVYVCPVSNCGKKMISKCGYVKHLEGHDADYNPDLDNASDDDRRPRGARRPLRNVCRFMNCGKRFASRAAYKQHVYNMHDIKEFLCPTCGKSFRRYSALKVHEQIHLPHKEFVCTECNMEFSQHANLKTHIKLHHEGHRFYCTKCGKGFLTNCTLKRHELIHTGVKDFKCDTCPAAFYTRRELTKHQRYHNVSAR

Sequence clustering based on sequence similarity using MMseqs2