Bneb007064.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Brachynemurus nebulosus
Gene Symbol
topi
Assembly
GCA_035578155.1
Location
JAPWDM010000001.1:131433694-131442213[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.00069 0.037 15.8 1.4 3 21 137 155 135 156 0.94
2 13 0.0045 0.25 13.3 6.0 1 23 180 202 180 202 0.97
3 13 0.0022 0.12 14.3 0.3 1 23 208 230 208 230 0.97
4 13 0.0028 0.15 13.9 1.2 1 23 285 307 285 307 0.98
5 13 0.45 24 7.0 0.5 1 20 313 332 313 334 0.91
6 13 0.029 1.6 10.7 1.8 3 21 351 369 349 373 0.88
7 13 0.0069 0.38 12.7 0.2 1 23 798 821 798 821 0.97
8 13 0.18 9.9 8.2 1.1 1 23 825 847 825 847 0.92
9 13 2.4e-05 0.0013 20.4 5.0 1 23 853 875 853 875 0.98
10 13 0.1 5.7 9.0 0.2 1 23 881 906 881 906 0.96
11 13 0.4 22 7.2 2.0 1 23 912 934 912 934 0.85
12 13 2.4e-05 0.0013 20.4 0.4 3 23 942 962 940 962 0.98
13 13 2.5e-05 0.0014 20.4 1.8 1 23 968 991 968 991 0.98

Sequence Information

Coding Sequence
atgaatCAGTATGAAAACTCTGAATCACTGCAAGAAATACAGTTAGAAAATACAATTCAATCACAAATTCTAGGCCAGTCGGTCTCCCAAGATATTAAAATTCACGAATCACCAATACAGTGGGGATATGTAATTGATACAAATTCCAAGTTAGATATAAAACTTCAAGATTATGAGTCAAAACCTGCAACTATTACCGTTATAAAGATAGGTGGAATAGAAGATTTAAACCCTCTCAATTTTACTGTCCCTTCTGCTATAAATGGTATTCATCAACAAGTTATTATGCAAGATAAATTGTTAATAGATCAAATTCAGCAAAATGCCATGCCACttacaaaaataccaaaacaaaAACCAAAAAAGAAATATCCTCCACAACCACCTTCTGACGCTCCTGCAGTAATTTGTCAGAATTGTGATGCATCATTTTCTACTAAATATCAATTCCAAAGACACCAGTGCGAGTTCAATGCTTCTAAAGTCATATTAAAATCTGaattaccaaaaaaacaaaTAGAAAAGCCAAAAACCAAACATGAATGTGATATTTGTCATAAATCTTTCATGACTGATCATAATTTAGATCGGCATCGATTATCTCATGGAGATAAGAAACCATTTACTTGTCAAAACTGTGGTAAAGGATTCATATTAGAATCTCGATTGAATACTCACGTCGAAAGTCATTGTAAGCTGTCTACTAATGAACccagaaaattttacaaaacaaatCTTTCAGTTTGGCAATGCTGGAACTGTCAACTGcaaacAACTGTTTCCGAAAAGAAAATAGTAATTCTTCCTGAGAAAAATGAACATACTTTTAAAATCATAAGTGTTGAACAACTATTTCAGTGTGAGTTTTGCAATCGTACATAtgcaaataaagaaattttgaaagagcATCAAAATTCACATGGCActgataaaaattatcaatGCATGTTTTGTAATGAATCATTTGAGAGTTATACAAATGCCCTGATACATTGGCAACATAAATGTGACAATAAAACTAACTTGTTTTGCTTACCAAGgataattatttgtaaattttgtgaCAAGGGTTTTAAATCACATGAATTATTATACgcacataaatataaattaaagcATTTCGTTCCGAAGGTATTTAgcgaaataaaacaaaataatttatcgGAATTGACAGCATCAATTAATTCTGATATCAATACATCCACAAATCAAGAATTGTCAATTTCTCAAATATTTGATTGTAACAATTCACAAAGTATTGATGAAGTAAAACCAGATTTAAATTTAACAGTATTTGGGGAGTTTCAAAATAGCAGTTTATTTTCGAATACAGATCAAAATGGGGTGCATTTTGAAGTAAATAGTAATTTTGGAACCATATCCATTTCAGACTACTCAGACGAtaataaaacaaacaattcAAGTAATTTACAATTGGATGTTACCAATAATTCCACATTTCAAATGCCTGACAATGGAGAAAATATAACGCAgttacaagaaaatttaaaagaaataagtaATGAAGTTAAAATTGCAATGGAAATTAATACCAAGGGTTTTCATGACGAGGATATCCCTGAAAATATTTCTCCTTTACACGATAATTGTACATCTGAAATAACACAAATTGATGCATTTTTAAATGATATAGCCAATAAAGTTTTAGACACAAATGATGTTGTggaacaaaagaaaaataatgacAATATTAAGTTAGCGAAAAATAATGGTgaagaaaaaaagatattagAAACTGTACAACAAACACCTGAAGCCGAGAAGGATAACAATAATTCTGATATTAGTAAACCAGAAGATGATTCTTTGCAAATTAGAAAAAAACTAAGAAGTTGTactaaaaaaaacaatgaaaaagaAGATATTTCAAAGGTCAGAAAGAAAACAACGAAAAATGTAGACGCTAAAAAGTATTCCAGAACATCGAAAGAAATTGTTGAGGATGGAACGTCTCGAGTTTGCACAAGGAATATGGAACGTTTACGAAATAAGAAAGGAAAAAgtaatgaaaagaaaaataaagaaagtGAAGATAGAAATAAGAATCAAGGaaatataaaagagaaatacaaAGAAGATAATAATTCATTACTGATTGTTACCGAAGAGAATCAAGTTTATTtggaagaaaagaaaaaatgttcaaaacgaAAATTGAATGACACACAATTAGAATATAACAAAGAAAATGAAATAGACGACGAAAATTCTATAACTATAAAGGACGAGCCAATTATTGAAGACGTAGTAAATGAAGAAAGAAAAGAAGAAATAAAAGTTCCCCCAGTTACACCAGCAAAAAGAGGACGGAAACCTAAACCAAAGTtgccaaaaaatgaaatagtattACTCTGTGGTGAAGGTTATCGATTTCAGTGTGAAAAATGTGCAAAAGTTACAAGAAGCATAGATGAGCTTATTGAGCATCGTCAATCAGATCACGGTAGCAATTTCGATTGCAAGGATTGTGGacaaGTAGTGCATAGTGCGAAAGCATTAATGATACATTGTCGAGCACATCAAAGTCTTAAGCCGTTTGTCTGTGATCAGTGTGGACGTTGTTACTCCCAAACATCCCATCTTTGGCAACACATGAGATTTCACCAaggtattaaGCCCTTTGCTTGTCCACATGAAGGTTGCGAAGCTAGATACACTATACGTCCAGATTTGAAGGACCATATTCGAAAGGTGCATACCAGAGAAAGACCATTTCGATGTGGTGTATGTGGGAAATGTTTTCTTACTGGTTCTGTTTATTATCAGCATCGTTTGATTCATAATAACGACCGACGTTATGGTTGTGATATATGTGATAAGCGCTTCTTTAGAGCTGATGCATTAAACAATCATAGACGTATTCATACTGATGAAAGACCGTTCCCATGTCCCGTTTGTGGACGTGAATTTCGTCAGAAAGGTGATCGAAATAAACATCATCGAACTCAACATCCTACTGAAGCTGCAATTACTGCTGTAAATTCGATTaatttatctaataataatattatGACTTTTACTACAGTTGGAAATTAA
Protein Sequence
MNQYENSESLQEIQLENTIQSQILGQSVSQDIKIHESPIQWGYVIDTNSKLDIKLQDYESKPATITVIKIGGIEDLNPLNFTVPSAINGIHQQVIMQDKLLIDQIQQNAMPLTKIPKQKPKKKYPPQPPSDAPAVICQNCDASFSTKYQFQRHQCEFNASKVILKSELPKKQIEKPKTKHECDICHKSFMTDHNLDRHRLSHGDKKPFTCQNCGKGFILESRLNTHVESHCKLSTNEPRKFYKTNLSVWQCWNCQLQTTVSEKKIVILPEKNEHTFKIISVEQLFQCEFCNRTYANKEILKEHQNSHGTDKNYQCMFCNESFESYTNALIHWQHKCDNKTNLFCLPRIIICKFCDKGFKSHELLYAHKYKLKHFVPKVFSEIKQNNLSELTASINSDINTSTNQELSISQIFDCNNSQSIDEVKPDLNLTVFGEFQNSSLFSNTDQNGVHFEVNSNFGTISISDYSDDNKTNNSSNLQLDVTNNSTFQMPDNGENITQLQENLKEISNEVKIAMEINTKGFHDEDIPENISPLHDNCTSEITQIDAFLNDIANKVLDTNDVVEQKKNNDNIKLAKNNGEEKKILETVQQTPEAEKDNNNSDISKPEDDSLQIRKKLRSCTKKNNEKEDISKVRKKTTKNVDAKKYSRTSKEIVEDGTSRVCTRNMERLRNKKGKSNEKKNKESEDRNKNQGNIKEKYKEDNNSLLIVTEENQVYLEEKKKCSKRKLNDTQLEYNKENEIDDENSITIKDEPIIEDVVNEERKEEIKVPPVTPAKRGRKPKPKLPKNEIVLLCGEGYRFQCEKCAKVTRSIDELIEHRQSDHGSNFDCKDCGQVVHSAKALMIHCRAHQSLKPFVCDQCGRCYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFRCGVCGKCFLTGSVYYQHRLIHNNDRRYGCDICDKRFFRADALNNHRRIHTDERPFPCPVCGREFRQKGDRNKHHRTQHPTEAAITAVNSINLSNNNIMTFTTVGN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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