Basic Information

Insect: Brachynemurus nebulosus
Gene Symbol: ZEB2
Assembly: GCA_035578155.1
Location: JAPWDM010000002.1:37013690-37022379[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 28 0.7 38 6.4 7.9 1 23 15 38 15 38 0.94

2 28 7.1e-05 0.0039 18.9 0.6 1 23 44 66 44 66 0.97

3 28 0.0023 0.12 14.2 1.0 1 23 73 95 73 95 0.98

4 28 4.3e-05 0.0024 19.6 0.5 1 23 101 124 101 124 0.91

5 28 2.6e-05 0.0014 20.3 4.9 1 23 129 151 129 151 0.99

6 28 0.00097 0.053 15.4 2.3 2 23 161 182 160 182 0.96

7 28 6.8e-05 0.0037 19.0 0.2 1 23 185 207 185 207 0.97

8 28 0.00011 0.0061 18.3 1.5 2 23 214 235 213 235 0.97

9 28 6.3e-07 3.4e-05 25.4 0.4 1 23 241 263 241 263 0.98

10 28 0.19 10 8.1 4.7 1 23 301 323 301 323 0.93

11 28 0.0017 0.094 14.6 7.6 1 23 329 351 329 351 0.98

12 28 0.015 0.82 11.6 4.4 1 23 358 380 358 380 0.98

13 28 0.00034 0.019 16.8 1.2 1 23 385 408 385 408 0.96

14 28 0.003 0.17 13.8 3.6 1 23 413 435 413 435 0.98

15 28 3.4e-06 0.00018 23.1 1.4 2 23 445 466 444 466 0.97

16 28 0.00011 0.0058 18.4 2.6 1 23 469 491 469 491 0.98

17 28 2.1e-05 0.0011 20.6 3.4 1 23 497 519 497 519 0.99

18 28 6e-07 3.3e-05 25.5 0.4 1 23 525 547 525 547 0.98

19 28 0.053 2.9 9.9 4.3 1 23 602 624 602 624 0.98

20 28 8.2e-07 4.4e-05 25.1 1.6 1 23 630 652 630 652 0.98

21 28 0.085 4.6 9.3 0.2 1 14 659 672 659 676 0.86

22 28 0.0009 0.049 15.5 2.5 1 23 687 710 687 710 0.96

23 28 0.00068 0.037 15.9 4.2 2 23 716 738 715 738 0.96

24 28 0.00033 0.018 16.9 5.1 1 23 747 769 747 769 0.99

25 28 0.00011 0.0061 18.3 0.2 1 23 772 794 772 794 0.97

26 28 0.00014 0.0077 18.0 2.1 2 23 801 822 800 822 0.97

27 28 2.9e-07 1.6e-05 26.5 0.7 1 23 828 850 828 850 0.98

28 28 0.023 1.2 11.1 0.5 1 23 856 879 856 879 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	28	0.7	38	6.4	7.9	1	23	15	38	15	38	0.94
2	28	7.1e-05	0.0039	18.9	0.6	1	23	44	66	44	66	0.97
3	28	0.0023	0.12	14.2	1.0	1	23	73	95	73	95	0.98
4	28	4.3e-05	0.0024	19.6	0.5	1	23	101	124	101	124	0.91
5	28	2.6e-05	0.0014	20.3	4.9	1	23	129	151	129	151	0.99
6	28	0.00097	0.053	15.4	2.3	2	23	161	182	160	182	0.96
7	28	6.8e-05	0.0037	19.0	0.2	1	23	185	207	185	207	0.97
8	28	0.00011	0.0061	18.3	1.5	2	23	214	235	213	235	0.97
9	28	6.3e-07	3.4e-05	25.4	0.4	1	23	241	263	241	263	0.98
10	28	0.19	10	8.1	4.7	1	23	301	323	301	323	0.93
11	28	0.0017	0.094	14.6	7.6	1	23	329	351	329	351	0.98
12	28	0.015	0.82	11.6	4.4	1	23	358	380	358	380	0.98
13	28	0.00034	0.019	16.8	1.2	1	23	385	408	385	408	0.96
14	28	0.003	0.17	13.8	3.6	1	23	413	435	413	435	0.98
15	28	3.4e-06	0.00018	23.1	1.4	2	23	445	466	444	466	0.97
16	28	0.00011	0.0058	18.4	2.6	1	23	469	491	469	491	0.98
17	28	2.1e-05	0.0011	20.6	3.4	1	23	497	519	497	519	0.99
18	28	6e-07	3.3e-05	25.5	0.4	1	23	525	547	525	547	0.98
19	28	0.053	2.9	9.9	4.3	1	23	602	624	602	624	0.98
20	28	8.2e-07	4.4e-05	25.1	1.6	1	23	630	652	630	652	0.98
21	28	0.085	4.6	9.3	0.2	1	14	659	672	659	676	0.86
22	28	0.0009	0.049	15.5	2.5	1	23	687	710	687	710	0.96
23	28	0.00068	0.037	15.9	4.2	2	23	716	738	715	738	0.96
24	28	0.00033	0.018	16.9	5.1	1	23	747	769	747	769	0.99
25	28	0.00011	0.0061	18.3	0.2	1	23	772	794	772	794	0.97
26	28	0.00014	0.0077	18.0	2.1	2	23	801	822	800	822	0.97
27	28	2.9e-07	1.6e-05	26.5	0.7	1	23	828	850	828	850	0.98
28	28	0.023	1.2	11.1	0.5	1	23	856	879	856	879	0.96

Sequence Information

Coding Sequence: ATGTTAAAAGAAGAAGATGTGTTCAAGTTAAAACATAGTGGATATCATTGCAATGTGTGCgacaaacgattttttcaaaaagaactTTGTCGACGCCACTATTATCGCATGCATGTTTATTCAGTTGGCTATCCGTGTGAAATTTgtcagaaaattttcaaatataaatggAATTTGATAACGCATTCGAAATTACACGATTTAAATCGACAAAAATACACATGTGAAATATGTAGTCGGGAGTATGCCACGCCCCAATCGTACAAGATGCATAAAAatagacatttaaaaaattattcatttaaatGCACCCAGTGTGGAAAAGGTTTCTATCAGAAAGCCGAATTAAAAATACACACAGATGCTGAACACAATGCAATACGTTACCAGTgtcaaatatgtaaaaaaacattttgcagTAAAGGCTACTTATCCGTACATTACCGTTCTCATGATCCAAATTACGTACCGCCTGAATTAAAGTGTCAATTGTGTGGCAAAACGTATCATTCGTCCGATCTTTATCGACGTCACGTCAAAGCACACGAGGGATTTCCGTGCGAGATGTGCGGAAAAACGTTGACCTCACGaatcagtttaaaaaatcacCTGCTAATACATCGCGGTGAAAAACCGTTAAGTTGTAACGTATGcggaaaatgttttaataaacgCGCCATTCTTAAAGTGCACATGCGCATTCATACAAACGAACGACCGTACGAATGCAAAGATTGTGGTAAACGATTTGCGCAACGTAGTCCACTGGTGATACACATGCGCTATCATACCGGCGAACGACCCTATCCGTGCCAACAAGTGTTAATCAAACAAGAGCCTCTGGCTATTCTAGAAATAAAACAAGAAGAAAGTGAAGAATTTACACAAACTTTCAATGGTTACCACTGTAACTattgtggaaaattttttttaacaaaaaaatattggaaatcaCATTTTGTTGTGCATTTAAAAGAGCGCCCGCACAAATGTGAAGTGTGTCAGAAAACGTTTAAACGTAAAAATCAGCTAACATGCCATCAACGTATACACAATACGGATCGAAAGAAATTCGTTTGTGATATCTGTTGCCGAGAATTTGCCAGTTGGCACTATTTCCAAGACCATCAGCGACGACACAATGGCTCCGCGTACGAATGTGACCAATGCGAAAAAACATTCTTAACCAAGTACCAGCTAAAAAATCACATCGACGTGAAACACAATCACGTACGATACTGTTGCGATCAGTGCAATAAATCATTCCTGTCAAAGGAATATTTGGTGCGACACGCCAAAACACACGATCCAAGCTACGTGGCACCAAGTCTCAAATGTGAATTATGCGGAAAATCCTATAAATCTCGATCCGAATACAATAGACACGTGAGATCGCACGAGGGCTTCCCGTGTCATCAGTGCGGACAAATATTTAAGTATGCGGAAAAATTAAAGTATCACATGTATACACACACCGGTGAGAAACCGTACAGTTGCACGTTCTGTGAGAAACGTTTCCGACGAAAAATCTATTTGACCGAACATCTACGAACGCACACGAAGGAGCGACCGTTCGAGTGTTCTGTTTGCGGTAAAGGGTTTACGCAACGTAGTCCATTAAAGATACACATGCGTAATCATACCGGCGAACGACCGTATACGTGTAAATTGGAAGTGACTTGGATAAAACAAGAACCTATCTTTGAGGAGATTCAAGCGTTTGCTGATACAGCATTCAATGAACAGTTACTAACtgatataaaatttgaagaagaTCAAGAATACATAAAAGTAAATCAAAAGTACAGTTGTACGCTATGTAAAAAAGTATTCCCGAAAAAGGGTAAATGTAAAGATCACTATCGgatacatttagacatgcgaCCATTTCCTTGTCCACATTGCGATAAAGCGTTCAAACTAAAAAGTGCACTTACGACACATTTAAAGACACACGATGTTGACCGAGCGAAATACGAGTGTTCTGTATGCGGAAAACCATATCGTTCGTCCGGCTACGCCCGACGTTGCGAAAAGAGTCACACCGGCGTATTTGCGTACATGTGCACTCAATGTGATAAAGGATTCCACTACAAAAGCCTTCTAGAAATCCATAAGCAAATCAAACATAACGCCACAAAACAACAGTGTCATATCTgtagtaaaatattttcaaatagtattaACTTCAAAAATCATTTTCGCAATTTTCACAACCCAAATCAAGTGATCAACGACTATAAATGCGAAATTTGCGGTAAAGTCTACCATTCACGGAAATTTTACAAACGACACTTAAAATCACATGAGGGTTTTGCGTGtgatatctgtggaaaaattttcgGATACGAACATGGCCTGAAAAATCATATCCTTATACATAAAGGTGAACGGCCGTGGAGTTGTAATGTGTGCGGGAAAACGTTCAATAAAAAACATATACTCACCGTACATTTACGAACACACACAAACGAAAAACCGTACGAGTGTAAAGATTGCGGTAAACGTTTTACGCAACGTAGTCCGCTTGTAATACACATGCGCTATCATACCGGCGAACGTCCGTATCCCTGTCGTCTATGTTCTGACGCAtttatcagtaaaaattatttacgcaTACACATGCAAAATACTCACGATTGTccaaatgtttaa
Protein Sequence: MLKEEDVFKLKHSGYHCNVCDKRFFQKELCRRHYYRMHVYSVGYPCEICQKIFKYKWNLITHSKLHDLNRQKYTCEICSREYATPQSYKMHKNRHLKNYSFKCTQCGKGFYQKAELKIHTDAEHNAIRYQCQICKKTFCSKGYLSVHYRSHDPNYVPPELKCQLCGKTYHSSDLYRRHVKAHEGFPCEMCGKTLTSRISLKNHLLIHRGEKPLSCNVCGKCFNKRAILKVHMRIHTNERPYECKDCGKRFAQRSPLVIHMRYHTGERPYPCQQVLIKQEPLAILEIKQEESEEFTQTFNGYHCNYCGKFFLTKKYWKSHFVVHLKERPHKCEVCQKTFKRKNQLTCHQRIHNTDRKKFVCDICCREFASWHYFQDHQRRHNGSAYECDQCEKTFLTKYQLKNHIDVKHNHVRYCCDQCNKSFLSKEYLVRHAKTHDPSYVAPSLKCELCGKSYKSRSEYNRHVRSHEGFPCHQCGQIFKYAEKLKYHMYTHTGEKPYSCTFCEKRFRRKIYLTEHLRTHTKERPFECSVCGKGFTQRSPLKIHMRNHTGERPYTCKLEVTWIKQEPIFEEIQAFADTAFNEQLLTDIKFEEDQEYIKVNQKYSCTLCKKVFPKKGKCKDHYRIHLDMRPFPCPHCDKAFKLKSALTTHLKTHDVDRAKYECSVCGKPYRSSGYARRCEKSHTGVFAYMCTQCDKGFHYKSLLEIHKQIKHNATKQQCHICSKIFSNSINFKNHFRNFHNPNQVINDYKCEICGKVYHSRKFYKRHLKSHEGFACDICGKIFGYEHGLKNHILIHKGERPWSCNVCGKTFNKKHILTVHLRTHTNEKPYECKDCGKRFTQRSPLVIHMRYHTGERPYPCRLCSDAFISKNYLRIHMQNTHDCPNV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -