Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00059 0.033 14.7 0.7 1 20 97 116 97 118 0.95

2 5 1.2e-05 0.00067 20.0 1.1 2 23 182 204 181 204 0.95

3 5 6.7e-05 0.0037 17.6 1.0 2 23 212 234 212 234 0.96

4 5 0.019 1 10.0 9.0 1 23 241 264 241 264 0.95

5 5 0.00057 0.032 14.7 1.1 2 23 272 295 271 295 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00059	0.033	14.7	0.7	1	20	97	116	97	118	0.95
2	5	1.2e-05	0.00067	20.0	1.1	2	23	182	204	181	204	0.95
3	5	6.7e-05	0.0037	17.6	1.0	2	23	212	234	212	234	0.96
4	5	0.019	1	10.0	9.0	1	23	241	264	241	264	0.95
5	5	0.00057	0.032	14.7	1.1	2	23	272	295	271	295	0.96

Coding Sequence: ATGGACATTGATTTTAATCACATAGAAAGAGATCTGCTAGACGATACTACAGATTCGTCAGTAAAACTGGAATTTAAAGAAGAAGACGACGATGAGCGATATACTATGGATCTTCTTCGGCTTGCAACTTGTGTAGAATCAAATACAGATCCAATTGAATTCAACTCCACCGATGCAATAACGGATCCCAAAACTGGAAAAATGGTTTGCCTTCATTGCTTAGGTGAAATTGATTCAAGTTCCATTAATGCTCACATGGTTAATGTTCACAATTATAGAAAAATTCTTTTCAAATGTCACATCTGTCAGACAGTTTTTCAAGAACGCAAACTTTTACAAGTCCATAGAGAAGAATGTCGTCCTCTGCTAAAAACTACTAAGAAAAAATCAATGGGACAAATAATGAAAGAAGTGGACAAGATATTAAAGAATCCTGAAAATCTATTAGATACTGTAGCTTGTCCGGTTTGTGTTGTGGAAGTGCCAAAATTTTCACTGCGGGAACATGTGGATATAGAACATAGGAAGCCTGAAATTAATTTAACATGTCAGATTTGTAACAGAACCTTCAAGTCAAAGCTTACTCTAAAAGAGCATATTAAATTAGTGCATGAAGCTGTTGAAGATTCTGAGCAGTGTGAACTCTGCGGGCAAAAGTTTAGATCTCTTAAATATTTAGCCAACCATAAAAGAAATGTGCACCCGAGTGGTGACAAAATTCACAAGTGTACTGTTTGTGGCAAAGAGTTTAAAAGTCGTCTTTGTGTTCACCAACATATGAAGCATGTTCACCCTCCAGAGAGTGCAACTGTAGTATGTCCTCACTGCCCTAACAAGATTTTTAAATCAAGCATTAATTTACATCAACACTTAAAAGTGGCACATGGGATGAAGAAGAAGACTAAAATATAA
Protein Sequence: MDIDFNHIERDLLDDTTDSSVKLEFKEEDDDERYTMDLLRLATCVESNTDPIEFNSTDAITDPKTGKMVCLHCLGEIDSSSINAHMVNVHNYRKILFKCHICQTVFQERKLLQVHREECRPLLKTTKKKSMGQIMKEVDKILKNPENLLDTVACPVCVVEVPKFSLREHVDIEHRKPEINLTCQICNRTFKSKLTLKEHIKLVHEAVEDSEQCELCGQKFRSLKYLANHKRNVHPSGDKIHKCTVCGKEFKSRLCVHQHMKHVHPPESATVVCPHCPNKIFKSSINLHQHLKVAHGMKKKTKI

Sequence clustering based on sequence similarity using MMseqs2