Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.8 1e+02 3.7 0.8 2 23 169 189 168 189 0.78

2 6 0.00011 0.0059 17.0 4.2 1 23 196 218 196 218 0.96

3 6 8.2e-06 0.00046 20.5 1.1 1 23 224 246 224 246 0.99

4 6 0.00048 0.027 14.9 0.9 1 23 252 274 252 274 0.95

5 6 0.00022 0.012 16.0 3.6 1 23 279 302 279 302 0.96

6 6 1.9e-05 0.001 19.4 0.6 1 23 308 331 308 331 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.8	1e+02	3.7	0.8	2	23	169	189	168	189	0.78
2	6	0.00011	0.0059	17.0	4.2	1	23	196	218	196	218	0.96
3	6	8.2e-06	0.00046	20.5	1.1	1	23	224	246	224	246	0.99
4	6	0.00048	0.027	14.9	0.9	1	23	252	274	252	274	0.95
5	6	0.00022	0.012	16.0	3.6	1	23	279	302	279	302	0.96
6	6	1.9e-05	0.001	19.4	0.6	1	23	308	331	308	331	0.93

Coding Sequence: ATGAACACAATCCAGAAAACTACAATAATAAATCATCATTGTGAAATGGCTGAAACTAAATCCATTACAAATTTTACTAAATGCAGAATATGTCTAAAAGAAGGCGGAATACCCATTTATGGACCTGACTGTTCTACTGATCTATCGTACGATGTGAGAACATTTGGAGACATCGACATCAGCGAAGATGATGAGTTTCCTAAGTATTTGTGCAGTGCTTGTTACAAACTTTTACAATGTGCGATACTATTTCGAAAGGCAGCTAAACAATCCGAAATACTCTTGAGTGAATCAATTTTGAAAAACAGTTCTGTGTCTGTATCGGAGTTCAGTTGTAGTACGGAATCAGATGAACCTCAGAATGATTATTGTGAAAACAATGCAAATAATGATAGACCCACTCAGTGGTCATCAGTGCAACAGTATTTCTTAGATTTAAGCAACTGTGATCTCGATAACATAAAGTTACCTGTTTGTCTCAATTTAGCCAGAGGTAAAAAAGTCCAATGTCGCATATGCAAGAAAGTTGTTAGCAAAGGACATAGTAGAGATCACTATGCTATCCACGACTCTACTTTGCCTAAATACATTTGTCACATTTGTGGAAAGTCATTTCGTCAACAAAGCGCACATGCTAACCACAGGTTTACTCACAGTACAGATTTCAAATTCAAATGCAAGATCTGTCCATACAGAGGACGCAGTTCAAGTCTGCTTAAAGGTCATATGAAGACGCATACTGGAGATTATCGTTATTTGTGTACAGAATGTCCTGCCAGATTCTTGACTAAAAGCAATTTGAACAGACATAGTCTTCGGCACAAAGAATCGGCGTTTAAATGTGATACTTGCAAAAAGGCTTTTCATTCAAAACTATACTTACAAAGACATTATGAAGTAGATCATTTAGGAGTGAAAAACTACAGCTGCAACTTGTGTGGCAAAGCTTTTGGCTACAGAAAACAAATGAGGAGACACCAAATAGATGTACACAAGCAAGAAAAGAAGTCGCCTGGCCGAATGCCTTCATATTTGAATAATAAATTAAATGCAGACATTTAA
Protein Sequence: MNTIQKTTIINHHCEMAETKSITNFTKCRICLKEGGIPIYGPDCSTDLSYDVRTFGDIDISEDDEFPKYLCSACYKLLQCAILFRKAAKQSEILLSESILKNSSVSVSEFSCSTESDEPQNDYCENNANNDRPTQWSSVQQYFLDLSNCDLDNIKLPVCLNLARGKKVQCRICKKVVSKGHSRDHYAIHDSTLPKYICHICGKSFRQQSAHANHRFTHSTDFKFKCKICPYRGRSSSLLKGHMKTHTGDYRYLCTECPARFLTKSNLNRHSLRHKESAFKCDTCKKAFHSKLYLQRHYEVDHLGVKNYSCNLCGKAFGYRKQMRRHQIDVHKQEKKSPGRMPSYLNNKLNADI

Sequence clustering based on sequence similarity using MMseqs2