Basic Information

Gene Symbol
-
Assembly
GCA_003987935.1
Location
NW:118572-120834[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.83 38 4.5 0.3 1 19 200 218 200 223 0.93
2 9 1.2 52 4.1 1.1 2 23 267 287 266 287 0.89
3 9 6.1 2.8e+02 1.8 2.0 2 23 299 320 298 320 0.93
4 9 0.9 41 4.4 0.9 3 23 345 364 344 364 0.91
5 9 5.3e-06 0.00024 20.9 1.4 1 23 371 393 371 393 0.99
6 9 0.11 5.1 7.3 0.4 1 23 399 421 399 421 0.98
7 9 4.6e-07 2.1e-05 24.2 2.7 1 23 427 449 427 449 0.99
8 9 9.5e-05 0.0043 16.9 5.7 2 23 456 478 455 478 0.96
9 9 0.00013 0.0059 16.5 0.4 3 23 486 507 484 507 0.96

Sequence Information

Coding Sequence
ATGTCAATAAAGGAAGATGgtttaatgttttcattaaataagTGCAGAATATGCTTAAAATCGGGAGAAATCTTTATCCCAGGGATTGAAAATCTTTTAGAACAAGTTATTGAATTCGGTGGTGTGAAAATAACGGAAGATGATTTATTTCCTAAACATATATGCGATTCTTGTTACTCGTTACTTAAAGCTGCCTTACTTTTCCGACAGAAAGCGCAGAATTCGGAGAGGATTCTCAATTCTAAGAAGATGACTCTAGATTCTGAGGTAGCCAGCAGCGATTCAAAAAGTTCAGCAGACGAGGAAGACTTACACAATTTTAATGAACATAGCCAAACATATAGAAAGATTCAGCCAAAGCTCCAGGTTTTGGAAAACGACTGTAATGACAAATTTTCTGGTGATGAATCAACATCTCGTAATGGCGATTTCCAAATCGAAGACGAATTGGAAAGCTCTGGGTCAGAAAGAGAATATTTGGAGATAAATGATGACACTGATGATTTTCTGAGTACtaatgtaatgtgtgtaataaaTCAAGATagtgaaattaatttagtttctaATAAGGATAACGAAAACTATCATATAGAACAATACCAATGCGGTATGTGTAGTATGATTAGTGAAACCCTAGATAAGTTGGAGATACATTGTGAATTGAATCATAACATTAAGGTAACTGATACTATGAAATGTGATGTGTGTAAGGAAGATGTTAGTGTCGCGATTCAACACATACACATGAAACAACATAAAGATGAATATAaacgaaaaagaagaaaagtagGAAAAATAGAATGtaatatttgcaaaaaatatattatgaaaaccTATATCAAATATCATATGAAAATGCATGGTCCGGAAACTGAAAGAgccgaaagaaaaaaatattgccgtTTGTGCCAAAAGCCAATATCGTTACACTATTTTGTCAGTCACCTGAGAAGAGTACATCAAAGAGGGCCAAATGAGGAAAAAATAGACCAAGCGAATTTAATTAACGTTAACAAAGATTCATTTGAAAACTGTCCAATATGTGAAAAATTGGTGCACAAATCAAAGTACAAAGAACATCTAGCTGATCACGGTAAGCCTCCAAAGaaatatgtatgtgaatattGTGCAAAAGAATTTAGATATCAATCAGCCTTTAAAACACATCAGTTGACTCACACAGATGAGTTTAAATACCAGTGTCAGTTTTGCCCATACAAAGCTCAATATTTAGGACTCATTAAAGTGCATGTTAGGACTCATACTGGAGATTATAACTATAAATGTCCACATTGCCCATCAAAATTCATAACAAAGAGTAATCTCAACCAGCATATCCAAAGGCATAATGTTCGTGGGAATATTAAATGTCATACATGCAATAAATACTTCtatcgtaaaagtaatatgGAAAAACATTACTCAACAAAACATTTGGGCATACGAGATGTAATCTGTGATATCTGCGGTACAGGCTTCAGCCACAGAGATGAAATGCTAAGTCATCAACTTAGAATGCACAACAGGGAGAGGTTACTTCGTCGGGTTCCGACCTATCTGAGAGTAGCTAGAGAAAAGGAAAAAGATGAAATTGACATTAAGCAACAGCAGTTGCaaaaattatga
Protein Sequence
MSIKEDGLMFSLNKCRICLKSGEIFIPGIENLLEQVIEFGGVKITEDDLFPKHICDSCYSLLKAALLFRQKAQNSERILNSKKMTLDSEVASSDSKSSADEEDLHNFNEHSQTYRKIQPKLQVLENDCNDKFSGDESTSRNGDFQIEDELESSGSEREYLEINDDTDDFLSTNVMCVINQDSEINLVSNKDNENYHIEQYQCGMCSMISETLDKLEIHCELNHNIKVTDTMKCDVCKEDVSVAIQHIHMKQHKDEYKRKRRKVGKIECNICKKYIMKTYIKYHMKMHGPETERAERKKYCRLCQKPISLHYFVSHLRRVHQRGPNEEKIDQANLINVNKDSFENCPICEKLVHKSKYKEHLADHGKPPKKYVCEYCAKEFRYQSAFKTHQLTHTDEFKYQCQFCPYKAQYLGLIKVHVRTHTGDYNYKCPHCPSKFITKSNLNQHIQRHNVRGNIKCHTCNKYFYRKSNMEKHYSTKHLGIRDVICDICGTGFSHRDEMLSHQLRMHNRERLLRRVPTYLRVAREKEKDEIDIKQQQLQKL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00237071;
90% Identity
iTF_00237071;
80% Identity
-