Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 1.6 96 3.9 0.0 5 15 25 35 24 38 0.87

2 7 0.7 42 5.1 0.2 3 23 41 62 40 62 0.95

3 7 5.6e-06 0.00033 21.1 1.1 1 23 161 184 161 184 0.95

4 7 2.3 1.3e+02 3.5 3.0 2 23 220 241 219 241 0.77

5 7 0.52 31 5.5 0.1 8 23 250 265 250 265 0.95

6 7 0.00058 0.034 14.8 1.1 1 23 272 294 272 294 0.98

7 7 0.011 0.63 10.8 4.5 1 17 300 316 300 322 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	1.6	96	3.9	0.0	5	15	25	35	24	38	0.87
2	7	0.7	42	5.1	0.2	3	23	41	62	40	62	0.95
3	7	5.6e-06	0.00033	21.1	1.1	1	23	161	184	161	184	0.95
4	7	2.3	1.3e+02	3.5	3.0	2	23	220	241	219	241	0.77
5	7	0.52	31	5.5	0.1	8	23	250	265	250	265	0.95
6	7	0.00058	0.034	14.8	1.1	1	23	272	294	272	294	0.98
7	7	0.011	0.63	10.8	4.5	1	17	300	316	300	322	0.88

Coding Sequence: ATGAATTCATTACAACTGGAACTTTGTGAGAATGATTATTACAACAGTGGAAGAGTTGAAATAACAGGGACAAAATGTGGAGAAATCTTTACAACAAATAGTGAAATTTTCAATGTTTTGTGTACATTTTGTGGGACAATATTGAGAGACATTGAAGGATTCACGTTACATTTCGAGACGAACCACAATAACCAATTTGAAGATGATGTAGAAATAAAAATTTCAACACATCTAATTGAAAAATGTACATTGGAAGTAAGTAATGACTCAGAGGATCCGATTTTAGAGAATATAATTAAAATTGTTGATGCATCAGATTTAAAGAATGAGGGTACAGATTCAGAAAGTATTTTAGAAAGAAACATTTATTTTCATGATAAAACTGAAATAGAAGACGAAAAAAAATCGAATGAACAACCAAAAGAATATCACACTAGAAAAAAGCCACGAAAAATAAGTCGTAGTAAAATGCCTACTTTACATGCTTGTAATATTTGTAATAAAGTTTTTAAACAAGAATCTGTTTTACAAAGCCATATAAAATATGACCATAACACTACATATTCATTTGTGGATAATTTATTAACTCAACAAGGAAATCAAGAGAGTGATAGTTTCAATTTGGATCCTGTACAATCAATAGCAAATGATCCTCTCAAATGTCGTTACTGTGATCTCCGTTTCAAAGGACGTGTACGCAGATTTGAGCATGAATGTTTacatactggtgaaagaccatattcatgtaaaacattcaTGTCAAAAGAAAATCTAAAAGGACATCAAGTTGTTCATAACAAGGATTATAGACCATATAAATGTGATGTGTGTGATGCAACATTTCAAAGAAGGAATGCATTTTCAGAGCATAAAAAACTTCATTCAGATGAACTTCGATACACTTGTAATATTTGTGGAAAAGGTTTTAAGCAATTTTCTGGATTATATTGTCATAAGAAGTGTCACGGGGAAGCTATAGGTCAATCTCGAAAATCCGAAAGTACTACTCGAAAGAAAAGAATTTGA
Protein Sequence: MNSLQLELCENDYYNSGRVEITGTKCGEIFTTNSEIFNVLCTFCGTILRDIEGFTLHFETNHNNQFEDDVEIKISTHLIEKCTLEVSNDSEDPILENIIKIVDASDLKNEGTDSESILERNIYFHDKTEIEDEKKSNEQPKEYHTRKKPRKISRSKMPTLHACNICNKVFKQESVLQSHIKYDHNTTYSFVDNLLTQQGNQESDSFNLDPVQSIANDPLKCRYCDLRFKGRVRRFEHECLHTGERPYSCKTFMSKENLKGHQVVHNKDYRPYKCDVCDATFQRRNAFSEHKKLHSDELRYTCNICGKGFKQFSGLYCHKKCHGEAIGQSRKSESTTRKKRI

Sequence clustering based on sequence similarity using MMseqs2