Basic Information

Gene Symbol
-
Assembly
GCA_014737395.1
Location
JACXII010000067.1:1242798-1244647[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.24 19 5.9 1.2 1 11 247 257 247 261 0.84
2 8 6.5e-05 0.0051 17.1 3.9 3 23 270 290 269 290 0.98
3 8 0.0016 0.13 12.7 1.8 1 23 291 313 291 313 0.98
4 8 0.035 2.8 8.5 1.1 1 23 322 345 322 345 0.96
5 8 0.0036 0.28 11.6 0.9 1 23 371 393 371 393 0.94
6 8 0.0089 0.7 10.3 0.3 1 23 430 452 430 452 0.98
7 8 0.00016 0.013 15.8 2.8 2 23 462 483 462 483 0.98
8 8 2.2e-06 0.00017 21.7 1.7 1 23 488 510 488 510 0.98

Sequence Information

Coding Sequence
ATGTTATCCTGCAAGGCACACGGTTGTCTTTCAAATGAAAATACGAAAGTTGACGGTAAAGATATTTTACTATTTTGTTTTCCTCAAGAAATTGAACGAAGGAATGAATGGTTTAAGAACTGTCAATTGAATGAAAATACTGAAAGTGATAAGACGCTCTATCTCTGTGAATTGCACTTTGATAAAACATGTTTTACTGATTCAATGGAATTAATTCCTAATGCTGTCCCAACTATTTTTAACATATTAGATGAAGGCCAAAGAAAACGTAAAGCTGAAGATGAACCTGGATGTAGATCACCTACAATTTCAGCAATAAAGCAGAAAAAATTGGATAGCGATTCTCATAGCCTAGTAACTCCGCCACAAAGCCCCTGCACTCAATCAGTAGAAAATAATGATAAAACGAACGAAGAAGAGACAATGGACATATGTTCTGATCATGAGATATCATTAAATGGATCTGCTGATATAAAACCAGAATTGTATCAAAAAGTGACAATAGGAAAGAAGTTGTATCGTTTAACAATACAAATAGATAAAATATATGGGAAGCCATGTCCAAGATCAAAAAAGCTCAAAATGCTGACACAGCTAATAAAAGGAAGTCAACAATTCTCAGAGAATACGTATAATACTAATCAAGGAAATCAGTCTTTAGAAAAAGTTAGTAGAAAGGCCATTTGTGCAAAAGGTGGATGTAAATTAAAAAAGTCAATTTATGATTCAAAGCCAGCATTTCAATGTGAACACTGTGATAAATATTACGTAATGAAGAAAAGTGATAACCGAGAGGAAAAAAAAGCTTGTACTATGTGTCATAAAACTTTTTCATCTTCCCAATCTCTATATCTTCATACTAAAACTCATTTTGTATGTGATATGTGCCAAACTGAATGTAGCTCACAAGTGACTTACGATAAGCATATAAGATTACACGTTAGTACCGATCCATTGCATCCATATAAGTGTCATCAGTGTATAGAAACGTTTGAACTTAAGGAAGATGTGAGGCAACATTATCTAATCGTTCATCCTACTATAAAATTACAAAACACAATTCTGCAAGTGACTGCACCATCTTTGACACAGCAAATATCTCCACAAGATTATCGTTGTATTAGTTGTAATATTACGTTTAGAAATGAACAAGCCTACAGGAATCATATAAATTCCCATAAAAAGAAAGAGGGACTAAGGTGCAGTATTGGTGATAGTACCAACAATATATTTCCAGTACCTAATCCGTTAACTGGTAGCCAAATAGGTATTCTTCGAGCTGTAAAATTCAGTTGTAGAGTATGTTCGATGGAATTTGATAACGTCGGTGAAGTTGATAAGCATACTAGAACTCATTTGGAAGAAGATAGTGAGGAGGAGCGCAAGTGCAATATTTGTAAAAAACTATTTAAAACGACCACACAACTCAACGAACATTTAAAGTACCACCTGTCCCGTGCACATTCTTGTCCCGTATGTTCCAAAGCTTTTATTAACAGAACTACTTTAAAAATACATTTAAAAACACACGTTGAATCATAG
Protein Sequence
MLSCKAHGCLSNENTKVDGKDILLFCFPQEIERRNEWFKNCQLNENTESDKTLYLCELHFDKTCFTDSMELIPNAVPTIFNILDEGQRKRKAEDEPGCRSPTISAIKQKKLDSDSHSLVTPPQSPCTQSVENNDKTNEEETMDICSDHEISLNGSADIKPELYQKVTIGKKLYRLTIQIDKIYGKPCPRSKKLKMLTQLIKGSQQFSENTYNTNQGNQSLEKVSRKAICAKGGCKLKKSIYDSKPAFQCEHCDKYYVMKKSDNREEKKACTMCHKTFSSSQSLYLHTKTHFVCDMCQTECSSQVTYDKHIRLHVSTDPLHPYKCHQCIETFELKEDVRQHYLIVHPTIKLQNTILQVTAPSLTQQISPQDYRCISCNITFRNEQAYRNHINSHKKKEGLRCSIGDSTNNIFPVPNPLTGSQIGILRAVKFSCRVCSMEFDNVGEVDKHTRTHLEEDSEEERKCNICKKLFKTTTQLNEHLKYHLSRAHSCPVCSKAFINRTTLKIHLKTHVES

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01419040;
90% Identity
iTF_00227510;
80% Identity
iTF_00233273;