Basic Information

Insect: Bombus polaris
Gene Symbol: topi
Assembly: GCA_014737335.1
Location: JACXIO010000253.1:1074631-1077204[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 1.1 1.1e+02 3.8 3.9 1 23 251 273 251 273 0.88

2 15 0.065 6.6 7.7 1.1 2 23 280 302 279 302 0.95

3 15 0.0018 0.18 12.6 0.4 2 21 309 328 308 329 0.92

4 15 0.00045 0.046 14.4 2.4 1 23 336 358 336 358 0.97

5 15 1.4e-07 1.4e-05 25.5 0.9 1 23 364 386 364 386 0.97

6 15 0.14 14 6.6 6.5 1 23 435 457 435 457 0.97

7 15 0.028 2.8 8.8 1.4 1 23 463 485 463 485 0.94

8 15 0.013 1.3 9.9 0.7 1 23 495 518 495 518 0.94

9 15 0.11 12 6.9 0.0 1 20 532 551 532 553 0.92

10 15 0.0045 0.46 11.3 0.1 1 23 558 580 558 580 0.98

11 15 2e-06 0.0002 21.9 3.1 1 23 586 608 586 608 0.98

12 15 0.00013 0.013 16.2 0.4 1 23 614 637 614 637 0.97

13 15 0.049 5 8.1 0.7 1 23 643 665 643 665 0.89

14 15 3.2e-07 3.3e-05 24.4 2.2 1 23 671 693 671 693 0.99

15 15 6.2e-06 0.00063 20.3 4.9 1 23 699 722 699 722 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	1.1	1.1e+02	3.8	3.9	1	23	251	273	251	273	0.88
2	15	0.065	6.6	7.7	1.1	2	23	280	302	279	302	0.95
3	15	0.0018	0.18	12.6	0.4	2	21	309	328	308	329	0.92
4	15	0.00045	0.046	14.4	2.4	1	23	336	358	336	358	0.97
5	15	1.4e-07	1.4e-05	25.5	0.9	1	23	364	386	364	386	0.97
6	15	0.14	14	6.6	6.5	1	23	435	457	435	457	0.97
7	15	0.028	2.8	8.8	1.4	1	23	463	485	463	485	0.94
8	15	0.013	1.3	9.9	0.7	1	23	495	518	495	518	0.94
9	15	0.11	12	6.9	0.0	1	20	532	551	532	553	0.92
10	15	0.0045	0.46	11.3	0.1	1	23	558	580	558	580	0.98
11	15	2e-06	0.0002	21.9	3.1	1	23	586	608	586	608	0.98
12	15	0.00013	0.013	16.2	0.4	1	23	614	637	614	637	0.97
13	15	0.049	5	8.1	0.7	1	23	643	665	643	665	0.89
14	15	3.2e-07	3.3e-05	24.4	2.2	1	23	671	693	671	693	0.99
15	15	6.2e-06	0.00063	20.3	4.9	1	23	699	722	699	722	0.96

Sequence Information

Coding Sequence: ATGAATAGCGGAAGAACGGAGTCGATTAGCACATTAAGCGAGCATGAAGATGATTTTGATGAATTTGAAGGATCAATTATTTGGTCCCAGGAGGAACCATTTTCCTCGAATGAAATTTTAGAATTAGCTCCAGATCCCGATAAACAAAATCGATTAAAATCTTTATGTCGTTTATGTGCTGGAGAAACTTTACATCCGATTTACATCTATTCCGAATTTGGTGAATCTTTGAAACTTTTGCATAAAATAAACACATGTTTAAGTGTTAAGGTAAAGAAAACTGATCCTCTTCCCAAACAACTTTGTCCAACATGTGTTGAAAAGATTACTTGGTGCAATGAATTTGATGTTCAGTGTATTAGAGCTGAGGAAACTCTCCTTGAAATTTTAAAGCAAAACCATTCTTTCAATAATGCTAGAAATGTTCAAGAAAATTCTCAGGGGAATATTGATTCTTGTCCATTGTGTGTTGAAGGACGGATGAGAATTTATGAAGAAGATAAAGAGAGTAGAAAAGATGTTGAACTGTACGATAGCGATATTGTTCTTGAGAGTAGTGATGAGGAACAAATTCCTAATGAAATTAATATTGAACAGAATGAGGAACCAGAAAACGAATCTATAACTTTGTTCTGTTTGGGTACCAAGCAGAAATATTTGAAATGTGGAGCTTGTATGAATTTGTATCATACAAAAGAGACTCTTGATGAGCATAAATGCAAACCTAATTTACAATGTACTTCCAAACCTTATAAGTGTGATATATGCTTTGCAACTTTCACGTTTGAAGAACGATTGCAGTTTCATCAACATTTTCATAAAGATGCAAAAGCGTTGTATTGCGAAATTTGCAAAATTACGTTTGGGAAGGAATTAAAATTGTTTTATCACTACAAGAGATATCATTGTAAAGATGGTAGAGTATCCTGCTTACAATGTGGAAAACTATTTGAAAATCAAGAAGGATTAAAAAAACATGTATGTGTGGATGGAAAAACAAGACCTCATGTATGCGAAGTTTGTTCCAAGGGGTTCTGTGATGGATACACTTTGAAACGCCATGTGGTAACTCATCTTCCAGAAAAGCCATACAAATGTCCAGAATGTTCAAAAAGTTTCACACAGAAATCAAGACTGAATAAACACATTGCTGGGCACAGCATCATTTTAGAAAACAGTCAAACTATTTGGAGGTGTATTCGTTGCGGTGAAGTCTTTGGAAGTTGCGATTCCACAGATGAACACTGCAAAAAACATGAGGAGAAAATTAGTCTTATAGAAGAGATGCAAGTATTGAAATTGTACCATTGTGAATTCTGTAGCAGCCACTTTGCAGATATGGATCATTTAAAAACTCACAGAGAATCTCACGTTATTGAGAAACCATACTCTTGCAACCATTGTAACTCTACATTCAAATCTTTCGCAGAGGCTGTTCTTCACTGGAAAGAACACCCAAGAATATTCAAAGTGCTAGTAGTATTTTTGTGTGAGATTTGTGACAGAGATGTTAAGGAACTATCTCTGCTTTATAAGCATAAGCAGAAGAGACACCAACCAGTGCCTAGAAGATCAGAGAAGAGCAAGGAGAAGTTCATTTGTGAACTCTGTGGAAGTATTTTTGTGACTATAGAAGATTTTCAAGAACATGGAAAGTACAGATGCTCCAAATTCCCATGTGATATTTGTGGTAGTCTTTTACCAACTGCAAATTCTCTGAATGCTCATAAAAGAAGACATAGTGGACTAAGACCATATGTTTGCAATATCTGTGGTAAAAGCTACACTCAATCCAGTCATATGTGGACTCACAAAAGGTTCCACATGGGTGTAAAACCCTATGCCTGTGAATATTGTGACCAGAGATTCACAATAAAGCCAGATCTGGCAGACCATACTAGGAAAAAACATACAAGGGAAAGACCATTCAAATGTGATGTTTGCAACAAAGCTTTCCTAACTGGTTCTGTCTTCTACCAACATAGGCTAATACACAGAGGGGATCGTAGATACAAGTGCCACTATTGTGAAAAAGCATTCACCAGAACAGAAGCTTTAAACAATCACATAAAGATTCACACTGGTGAAAAACCACATGCATGTGATGTTTGTGGAAGATGCTTCAGACAAAAGGGAGACATGAGAAAACACAGGCGAACACAACATATTGCCAAACAAGACACAAAATAG
Protein Sequence: MNSGRTESISTLSEHEDDFDEFEGSIIWSQEEPFSSNEILELAPDPDKQNRLKSLCRLCAGETLHPIYIYSEFGESLKLLHKINTCLSVKVKKTDPLPKQLCPTCVEKITWCNEFDVQCIRAEETLLEILKQNHSFNNARNVQENSQGNIDSCPLCVEGRMRIYEEDKESRKDVELYDSDIVLESSDEEQIPNEINIEQNEEPENESITLFCLGTKQKYLKCGACMNLYHTKETLDEHKCKPNLQCTSKPYKCDICFATFTFEERLQFHQHFHKDAKALYCEICKITFGKELKLFYHYKRYHCKDGRVSCLQCGKLFENQEGLKKHVCVDGKTRPHVCEVCSKGFCDGYTLKRHVVTHLPEKPYKCPECSKSFTQKSRLNKHIAGHSIILENSQTIWRCIRCGEVFGSCDSTDEHCKKHEEKISLIEEMQVLKLYHCEFCSSHFADMDHLKTHRESHVIEKPYSCNHCNSTFKSFAEAVLHWKEHPRIFKVLVVFLCEICDRDVKELSLLYKHKQKRHQPVPRRSEKSKEKFICELCGSIFVTIEDFQEHGKYRCSKFPCDICGSLLPTANSLNAHKRRHSGLRPYVCNICGKSYTQSSHMWTHKRFHMGVKPYACEYCDQRFTIKPDLADHTRKKHTRERPFKCDVCNKAFLTGSVFYQHRLIHRGDRRYKCHYCEKAFTRTEALNNHIKIHTGEKPHACDVCGRCFRQKGDMRKHRRTQHIAKQDTK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00085636;
90% Identity: iTF_01417868;
80% Identity: -