Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.6e-05 0.0017 19.0 0.1 2 23 111 132 110 132 0.96

2 6 4.3e-06 0.00046 20.8 3.5 1 23 138 160 138 160 0.98

3 6 1.3e-06 0.00013 22.4 2.7 1 23 166 188 166 188 0.99

4 6 0.00047 0.05 14.4 0.3 1 20 194 213 194 216 0.93

5 6 3.6e-06 0.00038 21.0 0.7 2 23 223 244 222 244 0.97

6 6 6.5e-08 6.8e-06 26.5 0.5 1 23 250 273 250 273 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.6e-05	0.0017	19.0	0.1	2	23	111	132	110	132	0.96
2	6	4.3e-06	0.00046	20.8	3.5	1	23	138	160	138	160	0.98
3	6	1.3e-06	0.00013	22.4	2.7	1	23	166	188	166	188	0.99
4	6	0.00047	0.05	14.4	0.3	1	20	194	213	194	216	0.93
5	6	3.6e-06	0.00038	21.0	0.7	2	23	223	244	222	244	0.97
6	6	6.5e-08	6.8e-06	26.5	0.5	1	23	250	273	250	273	0.98

Coding Sequence: ATGACATCCATGTTTGAACAACAAATTAAAAGCGAACCCATGGGGTTTTATTCTGTTGCTTCGAGCCGGTCAGATGGTTCAAATTCTATGGTGAATTTGTCGGATGATCGTGAAGACCTTTCTCAGCAAGAAGGTCACCTACAACCCCAGCAACAGACTACGTTACAAATAAATCAGCAACAGGGTCAACAACAAACTCAACAACAGAGTCAACAGCAAACGCAACAACAGGGTCAACAACAGCAGAGTCAGACTGTGCAACAAGAAGTTCCAAACCGTCAATCTACTGGACAACAAACTGTCAAAGAGGGTTCACGGTCAAAGCCACAGCCCTGTAAGGTATGTGGCAAGGTGCTATCCTCTGCTTCGTCGTACTATGTACATATGAAGCTTCATTCAGGCAACAAACCATATCATTGTACGGTATGCGAAGCAAGTTTTTGTCGAAAACCATACTTGGAAGTGCACATGAGGACGCACACAGGAGAAAGACCTTTCCAATGTGAGCTGTGCTTGAAAAGGTTTACTCAAAAGAGCAGTCTTAATACTCATAAACGGGTGCATACAGGAGAAAGGCCGTATGCCTGCGACATTTGTCAGAAACGTTTTGCAGTGAAAAGCTACGTGACGGCACACCGTTGGAGTCACGTTGCCGAAAAGCCATTGGTGTGCGACAGATGTTCTCTCACATTCACGTCCAAGAGTCAATTTGCAATACACATCCGTACCCATACTGCAAGTACCACGTACGAGTGTAACATATGCGGACGTACCTTTGTACGCGATAGTTATCTCATACGACACCAAAATCGAGTACATCGTGACATGAATCAAAGCAGTACGAATCACAATCCATCTACGCCCCAGAGTACCGGTGGTGGCACTCCAGGTACAGGTTTCGAGAGCCCGGTTTGCGATTTACGCTACAGCGAAGGACCTTCCTCGTTGGACGGTTTAGCAGGTTCGAAAGGAGGGATCGCTGCTGAGATCGCGAGTTTAGCCAAGCAAAACAATCTTCAACTTCCTCTACCGTTGCTACATCCGCAGACTACCAACTAG
Protein Sequence: MTSMFEQQIKSEPMGFYSVASSRSDGSNSMVNLSDDREDLSQQEGHLQPQQQTTLQINQQQGQQQTQQQSQQQTQQQGQQQQSQTVQQEVPNRQSTGQQTVKEGSRSKPQPCKVCGKVLSSASSYYVHMKLHSGNKPYHCTVCEASFCRKPYLEVHMRTHTGERPFQCELCLKRFTQKSSLNTHKRVHTGERPYACDICQKRFAVKSYVTAHRWSHVAEKPLVCDRCSLTFTSKSQFAIHIRTHTASTTYECNICGRTFVRDSYLIRHQNRVHRDMNQSSTNHNPSTPQSTGGGTPGTGFESPVCDLRYSEGPSSLDGLAGSKGGIAAEIASLAKQNNLQLPLPLLHPQTTN

Sequence clustering based on sequence similarity using MMseqs2