Basic Information

Gene Symbol
-
Assembly
GCA_014737525.1
Location
JACXIT010000048.1:107839-111481[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 3.8e-05 0.0035 17.9 3.0 1 23 190 214 190 214 0.96
2 7 6.2e-06 0.00058 20.3 3.8 1 23 220 244 220 244 0.98
3 7 7.1e-08 6.6e-06 26.4 0.8 1 23 250 274 250 274 0.99
4 7 0.0034 0.32 11.7 0.5 2 23 281 304 280 304 0.93
5 7 3.7e-07 3.5e-05 24.2 0.5 1 23 310 334 310 334 0.98
6 7 0.00014 0.013 16.1 1.6 1 23 340 364 340 364 0.97
7 7 3.3e-05 0.0031 18.0 1.4 1 23 370 393 370 393 0.98

Sequence Information

Coding Sequence
ATGTCAACAGAAGGCGCAGAACTTTCAAATCGTTTCATGACTCGAGATGTCGAAACTATGTCGGACGAGATACAGAACAATCGTATGGATATACTGGAGTGTCTTTCAGTTTTAATTAATGAAAATAATTCTGGAAATGATCAAACAGAAGAATTAACACTAGATGAACACCTATTGAGTGGTGGTACAACCTTGACAGCAGTAACGTTGCCTGATGGAACGCAAGCATTTGTTACCAATAATTTCAACGATGATGATATGAATTTAAAAAGGCAAACAACATTAGAATTGGAAAGTGGAGATACCATATTGCTTCGAGATATAACAGAGTTTGCAGAAGGTAAACCACTTCAATTGGAATTAGAGCCAGCAACATTAGTTCAAGCTCGTGACTCTACCATAGAAAATGTTGAAAACTATCCCCATGTAGAGTTTATCGATGGTAATGCTTATATGGTAGCTGGCCATCTTGATATTAGCAAAGATTTATGGGAAATTGAAGATGGGAAATTGAAGAAAAAGGATTCCAAGATTTTATTAAATAAGCTATCTACATCAAGAATAAGACATCCTTGTCCAAGGGAGGGCTGTTCAAAGGTTTACAGTACACCTCATCATCTTAAGGTTCACGAACGATCTCACACCGGTCAACGACCATACAGATGCACACATCCAAAATGTAAGAAGAGCTTCTCGACAGGATACAGTTTAAAAGCACATTTGCGTACGCACACAGGAGAGAAACCTTACAAATGTCCAAACGAAACGTGCGATAAAAGTTTTAAAACATCCGGAGATTTGCTAAAACACGTACGGACCCATACTGGAGAACGGCCCTTCTTATGTCCGTACAATGGATGCGGTCGTTCCTTTACTACGAGTAATATTAGGAAGGTTCACGTCAGAACGCACACCGGGGAACGTCCATACAAATGTACACAACCTAAATGTGGCAAGGCGTTTGCTAGTGCAACAAATTATAAGAATCATATACGAATTCATTCGGGTGAAAAACCTTACGTATGCTCTATAGAAAACTGTGGAAGGAGATTCACAGAGTATTCTAGTCTTTACAAGCATCATCTCGTTCATACGCAACAACGTCCGTTCGAATGTAAAATTTGCTTGAGGAGGTACAGGCAAAGTAGTACTCTCGTGATGCATAAAAGAACTGCTCATTCATTAGTCGATAATGATGATAATGTCGATGTTCTTTGCCAAGAATCTGTACAAGAGTCTTTTAGTCGAAGCAAAGATAGACGAAAAGGAAGCATTATGCGAGATAACGGTAATTCGTCGTTAAAGATCACAGAAAAAGATGGACAAATACAGATTTCCAAAGCGACCGATGACTTAAATGATAACGAAACTCAGATTTTATTGGTCGGTGATCCTTCACAAATTGCAGCATTACAGAAAATTGAGCTAAACGGTGGTTTCGACGAACCTGGTATTGATACTTCATTCGAAGAACTAAATATAAAGATTGAAGATATAGAACTTGGATGGCATTGA
Protein Sequence
MSTEGAELSNRFMTRDVETMSDEIQNNRMDILECLSVLINENNSGNDQTEELTLDEHLLSGGTTLTAVTLPDGTQAFVTNNFNDDDMNLKRQTTLELESGDTILLRDITEFAEGKPLQLELEPATLVQARDSTIENVENYPHVEFIDGNAYMVAGHLDISKDLWEIEDGKLKKKDSKILLNKLSTSRIRHPCPREGCSKVYSTPHHLKVHERSHTGQRPYRCTHPKCKKSFSTGYSLKAHLRTHTGEKPYKCPNETCDKSFKTSGDLLKHVRTHTGERPFLCPYNGCGRSFTTSNIRKVHVRTHTGERPYKCTQPKCGKAFASATNYKNHIRIHSGEKPYVCSIENCGRRFTEYSSLYKHHLVHTQQRPFECKICLRRYRQSSTLVMHKRTAHSLVDNDDNVDVLCQESVQESFSRSKDRRKGSIMRDNGNSSLKITEKDGQIQISKATDDLNDNETQILLVGDPSQIAALQKIELNGGFDEPGIDTSFEELNIKIEDIELGWH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00684956;
90% Identity
iTF_01418523;
80% Identity
-