Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.5e-06 0.00012 22.1 2.1 1 23 83 105 83 105 0.97

2 6 0.00043 0.033 14.4 2.1 2 23 111 132 110 132 0.97

3 6 2.6e-05 0.002 18.3 1.2 1 23 138 161 138 161 0.97

4 6 1e-05 0.00081 19.5 3.7 1 23 167 190 167 190 0.95

5 6 3.1e-06 0.00024 21.2 2.7 1 23 250 272 250 272 0.98

6 6 2.5e-06 0.00019 21.5 0.7 1 23 276 298 276 298 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.5e-06	0.00012	22.1	2.1	1	23	83	105	83	105	0.97
2	6	0.00043	0.033	14.4	2.1	2	23	111	132	110	132	0.97
3	6	2.6e-05	0.002	18.3	1.2	1	23	138	161	138	161	0.97
4	6	1e-05	0.00081	19.5	3.7	1	23	167	190	167	190	0.95
5	6	3.1e-06	0.00024	21.2	2.7	1	23	250	272	250	272	0.98
6	6	2.5e-06	0.00019	21.5	0.7	1	23	276	298	276	298	0.98

Coding Sequence: ATGTCGGCAGAGAAACACGTGGATCAGTGCATTATGGGAGATACCGGCGTCAAATTGGTGGAACATCACATACCAGAAGTTATGGCCGGACAACAGCTAACCGTATCGCTTGAGCGACAACAACCTCGAGTTATCGAAACTGCTCCGATATATTCGACTCTACTTATTCATACGCCTCTACAATTTCCACATTCGTTGAACAAACAATACAATGGTTCTAATAGTACGAGCAAGGCGGAACCGACGTTTATTTGCGACCACTGTTCGAAGATCTTCAGGAGGAAGGTCACATTACGAGCGCACTTAGATACTCATAGTGGCACACGGGTCGAATGTTCGCTGTGCCATCAACTCCTGAAGACCAAGAAGACACTGCAGCGTCATATGCTGGTGCACAATGTCCGTAAGCTATACAGGTGTCCGGAATGCAACTTCTTCACAAGACGAAAGCAGGGTTTGATTCGTCATCAGATCAGGATGCACACGAAGATCGCCCGTTACAAATGTAACCTTTGCCCGAAGAAGTTTAAATATGAAGGTGATCTTAAAAGACATCATGAAAACAAGCACACGTTCAAACCGCGTATTCGCGACCTTCGTGGAAAATACGTTCAACATGCTCCTTCCCTTGAAAAGCACCACAGCATAACACATATAAGCTCGAACAGTGTAGATAACGAGAGAATTGAAAGTAATCAGAACGTAGCCGTTGAGTGTCCGTCGCAAAGCAGCGATCAAGAAAAGCTATTCAATTGCACCAAGTGCAAATGGCGATTCAGCAGCTTGAATTCATTAAACAATCACATGCAACGACATCTCCTCACCTTTAAATGCGACGTTTGTGGAGTCGTGTTTAAGTATAAGGCTTCGTTTTTGAAACATCAAGAATCGCACAAACAACCTGAACAGCCTTAA
Protein Sequence: MSAEKHVDQCIMGDTGVKLVEHHIPEVMAGQQLTVSLERQQPRVIETAPIYSTLLIHTPLQFPHSLNKQYNGSNSTSKAEPTFICDHCSKIFRRKVTLRAHLDTHSGTRVECSLCHQLLKTKKTLQRHMLVHNVRKLYRCPECNFFTRRKQGLIRHQIRMHTKIARYKCNLCPKKFKYEGDLKRHHENKHTFKPRIRDLRGKYVQHAPSLEKHHSITHISSNSVDNERIESNQNVAVECPSQSSDQEKLFNCTKCKWRFSSLNSLNNHMQRHLLTFKCDVCGVVFKYKASFLKHQESHKQPEQP

Sequence clustering based on sequence similarity using MMseqs2